JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2018, Vol. 32 ›› Issue (3): 23-26.doi: 10.6040/j.issn.1673-3770.1.2018.006

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Status of immunotherapy in allergic fungal rhinosinusitis

QIN Gang, LIANG Zhuoping   

  1. Department of Otolaryngology Head and Neck Surgery, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan, China
  • Received:2018-02-28 Online:2018-05-20 Published:2018-05-20

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Abstract: Allergic fungal rhinosinusitis(AFRS)is an allergic disease caused by a fungus that acts as an antigen at the nasal mucosa of atopic individuals, and produces a combination of type I and III allergic reactions. The incidence of AFRS is high, and it is easy to relapse after surgery and postoperative drug treatment. There are serious impacts on the quality of life in patients. Therefore, it is of great importance to seek a safe and effective comprehensive treatment plan. Immunotherapy performed as part of comprehensive therapy can significantly improve the clinical symptoms of AFRS and reduce the requirement for corticosteroids and other drugs. The clinical value of immunotherapy is confirmed further by the finding that patients with AFRS who receive this treatment do not need repeat surgery. However, the benefits of immunotherapy remain controversial owing to conflicting research findings, and therefore these benefits warrant further investigation in clinical practice.

Key words: Allergy, Sinusitis, Fungi, Immunotherapy

CLC Number: 

  • R765.4
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