Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (5): 139-143.doi: 10.6040/j.issn.1673-3770.0.2018.456

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PU.1 transcription factor and helper Th9 cells with allergic rhinitis

Xiaohan LIU,Xiaobing ZHANG()   

  1. Department of Otorhinolaryngology Head and Neck Surgery，the First Hospital of Lanzhou University，Lanzhou 730000，Gansu，China
  • Received:2018-10-16 Revised:2019-01-09 Online:2019-09-20 Published:2019-10-15
  • Contact: Xiaobing ZHANG E-mail:3127093863@qq.com

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Abstract:

Allergic rhinitis is an IgE-mediated type I allergic disease of the nasal mucosa. Previous knowledge of AR has been extended from the imbalance of Th1/Th2 type cytokines to the Th1/Th2/Th17/Treg cell pattern. The Th9 cells discovered in recent years play an important role in the occurrence and development of allergic diseases. PU.1 is an important transcription factor in the Ets family and plays an important role in the regulation of natural immunity and acquired immunity. The activation of PU.1 directly affects the developmental differentiation and biological characteristics of Th9 cells. This article summarizes the possible roles of transcription factors PU.1 and Th9 cells in the pathogenesis of allergic rhinitis.

Key words: Allergic rhinitis, Helper T cell 9, Transcription factor PU.1, Interleukin-9

CLC Number: 

  • R765.21
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