Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (5): 162-165.doi: 10.6040/j.issn.1673-3770.0.2019.240

• Brief Report • Previous Articles     Next Articles

A retrospective study on clinic manifestation and pathological of the larynx leukoplakia in 76 cases

Yangfan LIU1,Jian JIA2,Baoluo WAN1()   

  1. 1. Department of Otorhinolaryngology Head and Neck Surgery, The People′s Hospital of Zhengzhou University，Henan Provincial People′s Hospital, Zhengzhou 450003, He′nan, China
    2. Department of Otorhinolaryngology, People′s Hospital of Xixian，Xixian 464300，He′nan, China
  • Received:2019-05-10 Revised:2019-05-31 Online:2019-09-20 Published:2019-10-15
  • Contact: Baoluo WAN E-mail:wanbaoluo2013 @126.com

RichHTML

28

PDF (PC)

453

Key words: Leukoplakia, Pathological type, Prognosis, Dysplasia

CLC Number: 

  • R767

Fig. 1

Laryngoscopy results. a：White protruding lesion throughout the right vocal cord and at the front of the left vocal cord, the surface was not smooth. b：White lesion visible in the middle of the right vocal cord and the vocal cord are obviously congested，the surface was not smooth."

Fig. 2

Pathological manifestations. a：Squamous epithelial proliferated actively，moderate or severe dysplasia cells(hematoxylin-eosin staining, ×100). b: Severe hyperplasia in the squmous metaplastic epithelium(hematoxylin-eosin staining, ×100)."

Table 1

The clinical features, pathological type and prognosis in 76 patients [n(%)]"

临床因素 例数 复发 恶变
性别
男 71（93.42） 10（90.91） 5（100）
女 5（6.58） 1（9.09） 0（0）
年龄
<40 4（55.56） 1（9.09） 0（0）
≥40 72（44.44） 10（90.91） 5（100）
吸烟
是 61（80.26） 10（90.91） 5（100）
否 15（19.74） 1（9.09） 0（0）
饮酒
是 54（71.05） 9（81.82） 5（100）
否 22（28.95） 2（18.18） 0（0）
咽喉反流
是 39（51.32） 8（72.73） 4（75）
否 37（48.68） 3（27.27） 1（25）
病理类型
鳞状上皮单纯增生 33（43.42) 3（27.27） 0（0）
轻度异型增生 21(27.63) 4（36.36） 2（40）
中度异型增生 13（17.11） 2（18.18） 1（20）
重度异型增生 7（9.21） 2（18.18） 2（40）
原位癌 2（2.63） 0（0） （0）

Table 2

Analysis of disease factors in observation group and control group [n(%)]"

组别 例数 吸烟 饮酒 咽喉反流
病例组 76 61（80.26） 54（71.05） 39（51.32）
对照组 40 13（32.5） 9（22.5） 7（17.5）
χ2 - 25.884 24.897 12.523
P - <0.001 <0.001 0.001
1 van Hulst AM , Kroon W , van der Linden ES , et al . Grade of dysplasia and malignant transformation in adults with premalignant laryngeal lesions[J]. Head Neck, 2016, 38(Suppl 1): E2284-E2290. doi:10.1002/hed. 24185 .
doi: 10.1002/hed. 24185
2 中华耳鼻咽喉头颈外科杂志编辑委员会咽喉组, 中华医学会耳鼻咽喉头颈外科学分会咽喉学组 . 咽喉反流性疾病诊断与治疗专家共识(2015年)[J]. 中华耳鼻咽喉头颈外科杂志, 2016, 51(5): 324-326. doi:10.3760/cma.j.issn.1673-0860.2016.05.002 .
doi: 10.3760/cma.j.issn.1673-0860.2016.05.002
Subspecialty Group Of Laryngopharyngology, Editori, Subspecialty Group Of Laryngopharyngology, Society . Experts consensus on diagnosis and treatment of laryngopharyngeal reflux disease (2015)[J]. Chin J Otorhinolaryngol Head Neck Surg, 2016, 51(5): 324-326. doi:10.3760/cma.j.issn.1673-0860.2016.05.002 .
doi: 10.3760/cma.j.issn.1673-0860.2016.05.002
3 Remacle M , Eckel HE, Antonelli A , et al . Endoscopic cordectomy. a proposal for a classification by the working committee, european laryngological society[J]. European Archives of Oto-Rhino-Laryngology, 2000, 257(4): 227-31. doi: 10.1007/s004050050228 .
doi: 10.1007/s004050050228
4 Barnes L , Eveson JW , Reichard P , et a1 ．Pathology and genetics of head and neck tumours．WHO classification of tumours[M]．Lyon：IARCS Press, 2005: 177-180．
5 Cui WX , Xu W , Yang QW , et al . Clinical and pathological characteristics of vocal fold leukoplakia and influential factors of recurrence and malignancy[J]. J Clin Otorhinolaryngol Head Neck Surg, 2016, 30(24): 1926-1931. doi:10.13201/j.issn.1001-1781.2016.24.005 .
doi: 10.13201/j.issn.1001-1781.2016.24.005
6 Johnston N , Dettmar PW , Ondrey FG , et al . Pepsin: biomarker, mediator, and therapeutic target for reflux and aspiration[J]. Ann NY Acad Sci, 2018, 1434(1): 282-289. doi:10.1111/nyas.13729 .
doi: 10.1111/nyas.13729
7 陈东辉, 郑宏良, 肖水芳, 等 . 喉白斑诊断与治疗专家共识解读[J]. 中华耳鼻咽喉头颈外科杂志, 2018, 53(8): 570-574. doi:10.3760/cma.j.issn.1673-0860.2018.08.003
doi: 10.3760/cma.j.issn.1673-0860.2018.08.003
CHEN Donghui , ZHENG Hongliang , XIAO Shuifang , et al . Explanation of the experts consensus on diagnosis and treatment of laryngeal leukoplakia[J]. Chin J Otorhinolaryngol Head Neck Surg, 2018, 53(8): 570-574. doi:10.3760/cma.j.issn.1673-0860.2018.08.003 .
doi: 10.3760/cma.j.issn.1673-0860.2018.08.003
8 Luers JC , Sircar K , Drebber U , et al . The impact of laryngeal dysplasia on the development of laryngeal squamous cell carcinoma[J]. European Archives of Oto-Rhino-Laryngology, 2014, 271(3): 539-45. doi: 10.1007/s00405-013-2670-2 .
doi: 10.1007/s00405-013-2670-2
9 Young CK , Lin WN , Lee LY , et al . Laryngoscopic characteristics in vocal leukoplakia: inter-rater reliability and correlation with histology grading[J]. Laryngoscope, 2015, 125(2): E62-E66. doi:10.1002/lary.24884 .
doi: 10.1002/lary.24884
10 黄志刚 . CO2激光手术治疗咽喉部肿瘤[J]. 山东大学 耳鼻喉眼学报, 2018, 32(6): 1-3. doi: 10.6040/j.issn .
doi: 10.6040/j.issn.1673-3770.1
1673-3770.1.2018.022.
doi: 10.6040/j.issn.1673-3770.1
HUANG Zhigang . Treatment of throat tumors with CO2
doi: 10.6040/j.issn.1673-3770.1
laser[J]. J Otolaryngol Ophthalmol Shandong Univ,
doi: 10.6040/j.issn.1673-3770.1
2018, 32(6):1-3. doi: 10.6040/j.issn.1673-3770.1 .
doi: 10.6040/j.issn.1673-3770.1
2018.022.
doi: 10.6040/j.issn.1673-3770.1
[1] MIAO Hongli, ZHANG Yanchun, HAO Linna, TANG Le, HE Yingnan. Clinical features and prognostic analysis of active ocular toxoplasmosis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(1): 82-89.
[2] PENG Zhonghua, CHEN Zhu, YUAN Luohua, YU Shaolan, MA Yuling. Primary high-grade non-intestinal-type adenocarcinoma of the nasal cavity: a case report and review of the literature [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(1): 95-98.
[3] LI Zan, LU Qi, SHEN Weidong, HOU Zhaohui, WU Nan. Clinical diagnosis and treatment features of 18 cases of necrotizing otitis externa [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(6): 17-22.
[4] LIU Ziqi, HUANG Jiali, WANG Liqin, CHEN Xi, ZHANG Liqing, ZHOU Han. Application of narrow band imaging endoscopy combined with voice acoustic analysis in the differential diagnosis of vocal cord leukoplakia [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(6): 87-96.
[5] LIU Yuzhu, CHEN Yao, YUAN Tiejun, LI Chunsen, LI Bo. Larynx fibrosarcoma: a case report and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(6): 133-137.
[6] NIU Yanyan, GU Wei, JIN Xiaofeng, HUO Hong, YANG Dahai, CUI Tingting, WANG Jian. Expression analysis of pepsin in vocal cord leukoplakia tissues [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(6): 66-70.
[7] WANG Lei, WANG Gang, SUN Zhezhe, LIU Hongdan, HAN Haolun, LI Baowei, ZHANG Xiaoli, WU Wei. Correlations between vocal cord hyperplastic lesions, vocal cord leukoplakia, chronic laryngopharyngitis, and laryngopharyngeal reflux [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(6): 71-77.
[8] LI Meichen, CHEN Hailing, LI Yang, MA Dengdian. Mucocele of inferior turbinate: a case report and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(5): 91-94.
[9] YANG Kaiyan, TANG Fengzhu, QIN Qicai, LI Xuxiang, FENG Dayi, NONG Fengjing, YANG Qiuyun. Expression of abnormal spindle-like microcephaly associated protein in nasopharyngeal carcinoma and its clinical significance [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(3): 18-25.
[10] WANG Kaijian, CHEN Xuesheng, WANG Wei. A meta-analysis of the correlation between platelet-lymphocyte ratio and prognosis of laryngeal squamous cell carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(3): 67-73.
[11] ZHOU Xiaoqing, YAN Yajie, LI Yingchun. Treatment of hoarseness based on physiological function of the liver [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(5): 74-79.
[12] LIU Nan, PANG Mingjie. Review of factors influencing the prognosis of endoscopic dacryocystorhinostomy [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(5): 149-155.
[13] WU Bo, HUANG Tiande, YAN Bin, CHEN Yi, TANG Yong. Correlation between the anxiety-depression state and idiopathic tinnitus prognosis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(4): 46-52.
[14] SUN Yongqiang, SONG Zhongyi, WANG Chunfang, LI Xiao, FU Ying, PAN Xinliang. Prognosis and influencing factors in sudden deafness patients with acoustic stapedius reflex threshold [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(2): 7-14.
[15] HAN Feiyan, WANG Ying. Clinical analysis of 13 cases of neurilemmomas in the nasal cavity and paranasal sinuses [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(2): 21-25.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd