Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2022, Vol. 36 ›› Issue (2): 151-156.doi: 10.6040/j.issn.1673-3770.0.2021.070

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Research progress of SIRT1 activation by resveratrol in ocular diseases

ZHANG Yi, WANG Wenjun,YANG Anhuai   

  1. Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, China
  • Published:2022-04-15

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Abstract: Sirtuins are a class of histone deacetylases that regulate a variety of activities through the control of gene expression, DNA repair, metabolism, oxidative stress response, mitochondrial function, and other biological processes. Sirtuin 1(SIRT1)has been most widely studied. Resveratrol is a natural polyphenolic compound that upregulates SIRT1 activity. Resveratrol has strong antioxidant and anti-inflammatory activities, and has been widely studied in cardiac protection, neuroprotection, chemotherapy, and anti-aging. Oxidative stress and inflammation play key roles in the development and progression of eye diseases, which can lead to progressive vision loss and even blindness. This article briefly reviews the potential use of resveratrol in ocular diseases and the limitations of its applications.

Key words: Resveratrol, SIRT1, Oxidative stress, Inflammation, Histone deacetylase

CLC Number: 

  • R771
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