Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2022, Vol. 36 ›› Issue (3): 195-201.doi: 10.6040/j.issn.1673-3770.0. 2020.477

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Effects of three different nasal uses of glucocorticoid on mucosal outcome after endoscopic sinus surgery

CHEN Shiqin, WEI Pingcun, HU Yunlong, HU Jinwang   

  1. Department of Otorhinolaryngology & Head and Neck Surgery, Anhui No.2 Provincial People's Hospital, Hefei 230041, Anhui, China
  • Published:2022-06-15

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Abstract: Objective To study the effects of three different glucocorticoid administration methods on nasal mucosal outcome after endoscopic sinus surgery for chronic rhinosinusitis patients. Methods 60 patients who with chronic rhinosinusitis after endoscopic surgery were randomly divided into three groups, 20 patients cavities in each group. Respectively nasopore filled in surgical cavity and conventional hormone nasal spray(Group A), nasopore with budesonide suspension liquid filled and conventional hormone nasal spray(Group B), nasopore filled and hormone nasal spray at the head back position(Group C). Comparing nasal symptoms improvement and mucous membrane outcome between groups of patients. Results Visual analogue scale(VAS)and Lund-Kennedy scores of nasal endoscopy in group B and group C were lower than those in group A at the 2, 4 and 12 weeks after surgery(P<0.05). The rates of nasal vesicles, edema, secretion and scab in group B and group C were lower than those in group A at 2, 4 and 12 weeks after operation(P<0.05). The nasal scar adhesion rate of group B and group C were lower than those in group A at 4 and 12 weeks after surgery(P<0.05). At 4 and 12 weeks after surgery, VAS and Lund-Kennedy scores in group C were lower than those in group B(P<0.05). The incidence of nasal edema and secretions in group C were lower than those in group B at 12 weeks after operation(P<0.05). Conclusion The two methods of nasopore with budesonide suspension liquid filled in the nasal cavity joint with conventional hormone nasal spray,and nasopore filled joint with the hormone spray at the head back position after the operation play an active role after endoscopic surgery for chronic rhinosinusitis. They can relieving patients'symptoms, repairing and remodeling the mucous membrane in the operative cavity. And the effect of the hormone spray at the head back position is better.

Key words: Glucocorticoid, Chronic rhinosinusitis, Endoscopic sinus surgery, Mucous membrane, Visual analogue scale, Nasal endoscopic Lund-Kennedy scale

CLC Number: 

  • R765.4
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