Abstract: Objective To observe the measurement of retinal ganglion cell complex(GCC)thickness in young myopia patients by optical amplification effect and its relationship with axial length(AL)and spherical equivalent(SE). Methods From September 2021 to November 2021, 102 young myopia patients(eyes)were selected, including 38 eyes in low myopia group(-0.5 D~-3.0 D), 39 eyes in moderate myopia group(-3.25 D~-6.0 D)and 25 eyes in high myopia group(>-6.0 D). The thickness parameters of GCC were measured by optical coherence tomography(OCT), and the optical amplification effect was corrected for the measurement results. The relationship between GCC thickness and AL was compared by one-way analysis of varianceand Pearson correlation analysis. Results There were significant differences in average GCC thickness, superior GCC thickness and inferior GCC thickness among the three groups, whether corrected or not(all P<0.05). Before and after GCC thickness correction, there was significant difference in middle and high myopia group(all P<0.001), but there was no significant difference in low myopia group(all P>0.05). Before correction, the average GCC thickness, superior GCC thickness and inferior GCC thickness were negatively correlated with AL and positively correlated with SE(all P<0.05). FLV was negatively correlated with AL(P<0.05), GLV was negatively correlated with SE(all P<0.001). After correction, the average GCC thickness, superior GCC thickness and inferior GCC thickness were positively correlated with AL and negatively correlated with SE(P<0.001). Conclusion The effect of optical amplification should be considered in the measurement of GCC thickness in young patients with moderate and high myopia.

Key words: Optical coherence tomography, Myopia, Retinal ganglion cell complex, Optical amplification effect, Ocular axis length