山东大学耳鼻喉眼学报 ›› 2025, Vol. 39 ›› Issue (2): 116-120.doi: 10.6040/j.issn.1673-3770.0.2023.392
• 论著 • 上一篇
彭鑫,魏先锋,梁毅博,乔杰,王巍,林鹏,李丽
PENG Xin, WEI Xianfeng, LIANG Yibo, QIAO Jie, WANG Wei, LIN Peng, LI Li
摘要: 恶性肿瘤患者发生血栓栓塞的风险较非肿瘤患者高,这种血栓的发生与肿瘤之间的关系被称为特鲁索综合征(Trousseau's syndrome, TS)。不明原因的血栓事件可发生在诊断隐匿的恶性肿瘤之前,或与恶性肿瘤同时出现。TS相对罕见,临床上表现为反复发作的多灶性的梗死,预后较差。现报道1例TS患者并进行文献复习,希望有助于头颈外科同仁更好地认识该疾病,以期为改善患者的预后提供更多的临床经验。
中图分类号:
[1] 林玉凤, 拱忠影, 汪志云. 以反复多灶性脑梗死起病的卵巢癌致特鲁索综合征一例[J]. 中华老年心脑血管病杂志, 2021, 23(11): 1214-1215. doi:10.3969/j.issn.1009-0126.2021.11.024 LIN Yufeng, GONG Zhongying, WANG Zhiyun. A case of Trousseau’s syndrome caused by ovarian cancer with repeated multifocal cerebral infarction[J]. Chinese Journal of Geriatric Heart Brain and Vessel Diseases, 2021, 23(11): 1214-1215. doi:10.3969/j.issn.1009-0126.2021.11.024 [2] Lecumberri R, Páramo JA, Rocha E. Anticoagulant treatment and survival in cancer patients. The evidence from clinical studies[J]. Haematologica, 2005, 90(9): 1258-1266 [3] De Stefano V. Arterial thrombosis and cancer: the neglected side of the coin of Trousseau syndrome[J]. Haematologica, 2018, 103(9): 1419-1421. doi: 10.3324/haematol.2018.197814 [4] Sack GH Jr, Levin J, Bell WR. Trousseau's syndrome and other manifestations of chronic disseminated coagulopathy in patients with neoplasms: clinical, pathophysiologic, and therapeutic features[J]. Medicine, 1977, 56(1): 1-37 [5] Yoon DW, Shin DW, Cho JH, et al. Increased risk of coronary heart disease and stroke in lung cancer survivors: a Korean nationwide study of 20, 458 patients[J]. Lung Cancer, 2019, 136: 115-121. doi:10.1016/j.lungcan.2019.08.025 [6] Bao L, Zhang SY, Gong XY, et al. Trousseau syndrome related cerebral infarction: clinical manifestations, laboratory findings and radiological features[J]. J Stroke Cerebrovasc Dis, 2020, 29(9): 104891. doi:10.1016/j.jstrokecerebrovasdis.2020.104891 [7] 卫亚楠, 陈曦. 局部晚期头颈部鳞状细胞癌的化疗及靶向进展[J]. 山东大学耳鼻喉眼学报, 2021, 35(3): 118-124. doi: 10.6040/j.issn.1673-3770.0.2020.276 WEI Yanan, CHEN Xi. Progress in chemotherapy and targeted drug therapy for locally advanced head and neck squamous cell carcinoma[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(3): 118-124. doi: 10.6040/j.issn.1673-3770.0.2020.276 [8] Repetto O, De Re V. Coagulation and fibrinolysis in gastric cancer[J]. Ann N Y Acad Sci, 2017, 1404(1): 27-48. doi:10.1111/nyas.13454 [9] Ito S, Kikuchi K, Ueda A, et al. Changes in serial D-dimer levels predict the prognoses of trousseau’s syndrome patients[J]. Front Neurol, 2018, 9: 528. doi:10.3389/fneur.2018.00528 [10] Nouh AM, Staff I, Finelli PF. Three Territory Sign: an MRI marker of malignancy-related ischemic stroke(Trousseau syndrome)[J]. Neurol Clin Pract, 2019, 9(2): 124-128. doi:10.1212/CPJ.0000000000000603 [11] 陆中华, 韩一平, 周瑛, 等. 恶性肿瘤相关性脑梗死研究进展[J]. 中国脑血管病杂志, 2018, 15(4): 206-211. doi:10.3969/j.issn.1672-5921.2018.04.008 LU Zhonghua, HAN Yiping, ZHOU Ying, et al. Research progress of malignant tumor-related cerebral infarction[J]. Chinese Journal of Cerebrovascular Diseases, 2018, 15(4): 206-211. doi:10.3969/j.issn.1672-5921.2018.04.008 [12] 刘国红, 卞光利, 彭爱琴, 等. 表现为急性双侧前后循环脑梗死的Trousseau综合征的MRI特征[J]. 临床放射学杂志, 2019, 38(3): 406-409. doi:10.13437/j.cnki.jcr.2019.03.009 LIU Guohong, BIAN Guangli, PENG Aiqin, et al. The MRI features of trousseau's syndrome in which the symptom was acute cerebral infarct with bilateral anterior-posterior circulation involved[J]. Journal of Clinical Radiology, 2019, 38(3): 406-409. doi:10.13437/j.cnki.jcr.2019.03.009 [13] 李苗, 党晓凤, 薛艺东, 等. 特鲁索综合征一例报道并文献复习[J]. 实用心脑肺血管病杂志, 2021, 29(2): 133-136. doi:10.12114/j.issn.1008-5971.2021.00.017 LI Miao, DANG Xiaofeng, XUE Yidong, et al. Trousseau syndrome: a case report and literature review[J]. Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease, 2021, 29(2): 133-136. doi:10.12114/j.issn.1008-5971.2021.00.017 [14] 黎芳丽, 姜卉, 蒋锡丽. 特鲁索综合征相关性急性脑梗死的MRI表现[J]. 现代医用影像学, 2020, 29(5): 843-846. LI Fangli, JIANG Hui, JIANG Xili. MRI manifestations of acute cerebral infarction associated with trousseau syndrome[J]. Modern Medical Imagelogy, 2020, 29(5): 843-846. [15] 徐泽勤, 郭连瑞. 颈动脉狭窄诊疗进展[J]. 山东大学耳鼻喉眼学报, 2020, 34(4): 11-15. doi: 10.6040/j.issn.1673-3770.1.2020.054 XU Zeqin, GUO Lianrui. Advances in the diagnosis and treatment of carotid artery stenosis[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(4): 11-15. doi: 10.6040/j.issn.1673-3770.1.2020.054 [16] Tsushima M, Metoki N, Hagii J, et al. D-dimer and C-reactive protein as potential biomarkers for diagnosis of trousseau's syndrome in patients with cerebral embolism[J]. J Stroke Cerebrovasc Dis, 2020, 29(2): 104534. doi:10.1016/j.jstrokecerebrovasdis.2019.104534 [17] Nakao S, Masuda T, Sakamoto S, et al. Cerebral embolism during edoxaban administration for venous thromboembolism in a patient with lung adenocarcinoma: a case report[J]. Medicine, 2019, 98(12): e14821. doi:10.1097/MD.0000000000014821 [18] Dammacco F, Vacca A, Procaccio P, et al. Cancer-related coagulopathy(Trousseau's syndrome): review of the literature and experience of a single center of internal medicine[J]. Clin Exp Med, 2013, 13(2): 85-97. doi:10.1007/s10238-013-0230-0 [19] Bendas G, Borsig L. Cancer cell adhesion and metastasis: selectins, integrins, and the inhibitory potential of heparins[J]. Int J Cell Biol, 2012, 2012: 676731. doi:10.1155/2012/676731 [20] Ikushima S, Ono R, Fukuda K, et al. Trousseau's syndrome: cancer-associated thrombosis[J]. Jpn J Clin Oncol, 2016, 46(3): 204-208. doi:10.1093/jjco/hyv165 [21] Xavier FD, Hoff PMG, Braghiroli MI, et al. Rivaroxaban: an affordable and effective alternative in cancer-related thrombosis [J]. J Glob Oncol, 2017, 3(1): 15-22. doi:10.1200/JGO.2015.002527 [22] Raskob GE, van Es N, Verhamme P, et al. Edoxaban for the treatment of cancer-associated venous thromboembolism[J]. N Engl J Med, 2018, 378(7): 615-624. doi:10.1056/NEJMoa1711948 [23] Franco-Moreno A, Cabezón-Gutiérrez L, Palka-Kotlowsa M, et al. Evaluation of direct oral anticoagulants for the treatment of cancer-associated thrombosis: an update[J]. J Thromb Thrombolysis, 2019, 47(3): 409-419. doi:10.1007/s11239-018-1783-2 [24] Plantureux L, Mège D, Crescence L, et al. Impacts of cancer on platelet production, activation and education and mechanisms of cancer-associated thrombosis[J]. Cancers, 2018, 10(11): 441. doi:10.3390/cancers10110441 [25] Connolly GC, Phipps RP, Francis CW. Platelets and cancer-associated thrombosis[J]. Semin Oncol, 2014, 41(3): 302-310. doi:10.1053/j.seminoncol.2014.04.009 [26] Mai H, Xia J, Wu YJ, et al. Clinical presentation and imaging characteristics of occult lung cancer associated ischemic stroke[J]. J Clin Neurosci, 2015, 22(2): 296-302. doi:10.1016/j.jocn.2014.05.039 [27] 郭琳佳, 刘文宏. 恶性肿瘤合并急性脑梗死的临床特点及预后分析[J]. 中风与神经疾病杂志, 2019, 36(1): 37-42. doi:10.19845/j.cnki.zfysjjbzz.2019.01.008 GUO Linjia, LIU Wenhong. Clinical and prognosis features of acute ischemic stroke patient with cancer patient[J]. Journal of Apoplexy and Nervous Diseases, 2019, 36(1): 37-42. doi:10.19845/j.cnki.zfysjjbzz.2019.01.008 |
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