孕妇分娩前后鼻眼部症状变化规律分析

doi:10.6040/j.issn.1673-3770.0.2024.328

摘要/Abstract

摘要： 目的探讨有鼻炎症状的孕妇在分娩前后短期内鼻眼部症状的变化规律。方法针对妊娠晚期待产孕妇,使用问卷调查的方式收集她们的妊娠基线数据、既往病史、围产期内的鼻眼部症状,通过对孕妇分娩前后鼻眼部症状评分的比较,推测妊娠期鼻炎的发病率及其可能的危险因素。结果共有144例孕妇纳入研究,其中17例既往有鼻炎病史;在127例无鼻炎病史的孕妇中,42例(33.1%)出现妊娠期鼻炎的相关症状。妊娠期鼻炎孕妇与对照组孕妇在妊娠年龄、孕周及婴儿性别分布上差异无统计学意义(P=0.842;P=0.971;P=0.399)。有鼻炎症状的孕妇,在分娩后短期内鼻部症状评分即较分娩前显著下降,差异有统计学意义(P<0.01)。结论妊娠期鼻炎相关的鼻部症状于分娩后短期内可自行缓解。

关键词: 妊娠诱发鼻炎, 妊娠期鼻炎, 鼻部症状, 眼部症状, 分娩, 症状评分

Key words: Pregnancy Induced Rhinitis, Pregnancy Rhinitis, Nasal symptoms, Ocular symptoms, Delivery, Symptom scores

中图分类号:

R714.7

杨娟娟,郎永耀,周文成. 孕妇分娩前后鼻眼部症状变化规律分析[J]. 山东大学耳鼻喉眼学报, 2025, 39(2): 59-64.

YANG Juanjuan, LANG Yongyao, ZHOU Wencheng. Analysis of patterns of variation in nasal and ocular symptoms before and after delivery in pregnant women[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(2): 59-64.

参考文献

[1] Ramos CL, Namazy J. Monoclonal antibodies(biologics)for allergic rhinitis, asthma, and atopic dermatitis during pregnancy and lactation[J]. Immunol Allergy Clin North Am, 2023, 43(1): 187-197. doi:10.1016/j.iac.2022.07.001
[2] Namazy JA, Schatz M. Asthma and rhinitis during pregnancy[J]. Mt Sinai J Med, 2011, 78(5): 661-670. doi:10.1002/msj.20284
[3] Namazy JA, Schatz M. Diagnosing rhinitis during pregnancy[J]. Curr Allergy Asthma Rep, 2014, 14(9): 458. doi:10.1007/s11882-014-0458-0
[4] Grajczyk A, Sobczyk K, Zarzecka J, et al. Objective measurements of nasal obstruction and eustachian tube function in pregnant women[J]. J Clin Med, 2024, 13(9): 2671. doi:10.3390/jcm13092671
[5] Yang ZC, Wang LX, Yu Y, et al. Increased risk of postpartum depression in women with allergic rhinitis during pregnancy: a population-based case-control study[J]. Ann Otol Rhinol Laryngol, 2022, 131(10): 1137-1143. doi:10.1177/00034894211058135
[6] 张锟艺, 肖旭平. 妊娠期鼻炎患者临床治疗及用药方案的研究进展[J]. 山东大学耳鼻喉眼学报, 2023, 37(5): 175-183. doi:10.6040/j.issn.1673-3770.0.2022.349 ZHANG Kunyi, XIAO Xuping. Research progress in the clinical treatment and drug regimen for patients with pregnancy rhinitis[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(5): 175-183. doi:10.6040/j.issn.1673-3770.0.2022.349
[7] 中华耳鼻咽喉头颈外科杂志编辑委员会鼻科组, 中华医学会耳鼻咽喉头颈外科学分会鼻科学组. 中国变应性鼻炎诊断和治疗指南(2022年,修订版)[J]. 中华耳鼻咽喉头颈外科杂志, 2022, 57(2): 106-129. doi:10.3760/cma.j.cn115330-20211228-00828
[8] 庞冲, 边赛男, 张冰, 等. 儿童过敏性鼻炎粉尘螨特异性舌下免疫治疗短期疗效评估[J]. 山东大学耳鼻喉眼学报, 2022, 36(1): 70-74. doi:10.6040/j.issn.1673-3770.0.2021.117 PANG Chong, BIAN Sainan, ZHANG Bing, et al. Short-term effect of Dermatophagoides farinae specific sublingual immunotherapy for children with allergic rhinitis[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(1): 70-74. doi:10.6040/j.issn.1673-3770.0.2021.117
[9] 张杰,陈敏,申征征,等. 过敏性鼻炎与儿童新冠病毒肺炎感染及症状的关联性研究[J]. 山东大学耳鼻喉眼学报, 2024, 38(4): 36-42. doi: 10.6040/j.issn.1673-3770.0.2023.393 ZHANG Jie, CHEN Min, SHEN Zhengzheng, et al. Study on the correlation between allergic rhinitis and coronavirus disease-2019 infection and symptoms in children[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(4): 36-42. doi: 10.6040/j.issn.1673-3770.0.2023.393
[10] Orban N, Maughan E, Bleach N. Pregnancy-induced rhinitis[J]. Rhinology, 2013, 51(2): 111-119. doi:10.4193/Rhino12.045
[11] Scadding GK, Kariyawasam HH, Scadding G, et al. BSACI guideline for the diagnosis and management of allergic and non-allergic rhinitis(Revised Edition 2017; First edition 2007)[J]. Clin Exp Allergy, 2017, 47(7): 856-889. doi:10.1111/cea.12953
[12] Gilbey P, McGruthers L, Morency AM, et al. Rhinosinusitis-related quality of life during pregnancy[J]. Am J Rhinol Allergy, 2012, 26(4): 283-286. doi:10.2500/ajra.2012.26.3776
[13] Rieder W, Heinzer R, Baud D. Sleep apnea in pregnancy[J]. Rev Med Suisse, 2016, 12(536): 1816-1820
[14] 武琼, 李琳, 沙骥超. 妊娠期鼻炎的研究进展[J]. 临床耳鼻咽喉头颈外科杂志, 2017, 31(22): 1778-1782. doi:10.13201/j.issn.1001-1781.2017.22.020 WU Qiong, LI Lin, SHA Jichao. Research advances of pregnancy rhinitis[J]. Journal of Clinical Otorhinolaryngology Head and Neck Surgery, 2017, 31(22): 1778-1782. doi:10.13201/j.issn.1001-1781.2017.22.020
[15] Baudoin T, Šimunjak T, Bacan N, et al. Redefining pregnancy-induced rhinitis[J]. Am J Rhinol Allergy, 2021, 35(3): 315-322. doi:10.1177/1945892420957490
[16] Murphy VE, Jensen ME. Longitudinal changes in upper and lower airway function in pregnancy[J]. Immunol Allergy Clin North Am, 2023, 43(1): 17-26. doi:10.1016/j.iac.2022.07.005
[17] Ulkumen B, Ulkumen BA, Pala HG, et al. Pregnancy rhinitis in Turkish women: do gestational week, BMI and parity affect nasal congestion?[J]. Pak J Med Sci, 2016, 32(4): 950-954. doi:10.12669/pjms.324.10164
[18] Dzieciolowska-Baran E, Teul-Swiniarska I, Gawlikowska-Sroka A, et al. Rhinitis as a cause of respiratory disorders during pregnancy[J]. Adv Exp Med Biol, 2013, 755: 213-220. doi:10.1007/978-94-007-4546-9_27
[19] Ellegård E, Hellgren M, Torén K, et al. The incidence of pregnancy rhinitis[J]. Gynecol Obstet Invest, 2000, 49(2): 98-101. doi:10.1159/000010223
[20] Shushan S, Sadan O, Lurie S, et al. Pregnancy-associated rhinitis[J]. Am J Perinatol, 2006, 23(7): 431-433. doi:10.1055/s-2006-951302
[21] Hellings PW, Klimek L, Cingi C, et al. Non-allergic rhinitis: position paper of the European Academy of Allergy and Clinical Immunology[J]. Allergy, 2017, 72(11): 1657-1665. doi:10.1111/all.13200
[22] Gupta KK, Anari S. Medical management of rhinitis in pregnancy[J]. Auris Nasus Larynx, 2022, 49(6): 905-911. doi:10.1016/j.anl.2022.01.014
[23] Ulkumen B, Batir MB, Artunc Ulkumen B, et al. Role of VPAC1 and VPAC2 receptors in the etiology of pregnancy rhinitis: an experimental study in rats[J]. Braz J Otorhinolaryngol, 2022, 88(4): 505-510. doi:10.1016/j.bjorl.2020.06.015
[24] Kim J, Cheng MZ, Naclerio R. Management of the upper airway distress during pregnancy[J]. Immunol Allergy Clin North Am, 2023, 43(1): 53-64. doi:10.1016/j.iac.2022.05.010
[25] Kumar R, Hayhurst KL, Robson AK. Ear, nose, and throat manifestations during pregnancy[J]. Otolaryngol Head Neck Surg, 2011, 145(2): 188-198. doi:10.1177/0194599811407572
[26] Gani F, Braida A, Lombardi C, et al. Rhinitis in pregnancy[J]. Eur Ann Allergy Clin Immunol, 2003, 35(8): 306-313
[27] Caparroz FA, Gregorio LL, Bongiovanni G, et al. Rhinitis and pregnancy: literature review[J]. Braz J Otorhinolaryngol, 2016, 82(1): 105-111. doi:10.1016/j.bjorl.2015.04.011
[28] Indirani B, Raman R, Omar SZ. Hormonal changes causing rhinitis in pregnancy among Malaysian women[J]. J Laryngol Otol, 2013, 127(9): 876-881. doi:10.1017/S0022215113001692
[29] Maliqueo M, Cruz G, Espina C, et al. Obesity during pregnancy affects sex steroid concentrations depending on fetal gender[J]. Int J Obes, 2017, 41(11): 1636-1645. doi:10.1038/ijo.2017.159
[30] Al Atawi F, Warsy A, Babay Z, et al. Fetal sex and leptin concentrations in pregnant females[J]. Ann Saudi Med, 2005, 25(2): 124-128. doi:10.5144/0256-4947.2005.124
[31] Ellegård E, Karlsson G. IgE-mediated reactions and hyperreactivity in pregnancy rhinitis[J]. Arch Otolaryngol Head Neck Surg, 1999, 125(10): 1121-1125. doi:10.1001/archotol.125.10.1121
[32] Philpott CM, Conboy P, Al-Azzawi F, et al. Nasal physiological changes during pregnancy[J]. Clin Otolaryngol Allied Sci, 2004, 29(4): 343-351. doi:10.1111/j.1365-2273.2004.00815.x
[33] Ellegård EK. Clinical and pathogenetic characteristics of pregnancy rhinitis[J]. Clin Rev Allergy Immunol, 2004, 26(3): 149-159. doi:10.1385/CRIAI: 26: 3: 149
[34] 陶佳, 罗仁忠, 周丽枫. 妊娠期鼻炎的临床特点和治疗探讨[J]. 中国眼耳鼻喉科杂志, 2017, 17(1): 46-48. doi:10.14166/j.issn.1671-2420.2017.01.014 TAO Jia, LUO Renzhong, ZHOU Lifeng. Clinical characteristics and treatment of pregnancy rhinitis[J]. Chinese Journal of Ophthalmology and Otorhinolaryngology, 2017, 17(1): 46-48. doi:10.14166/j.issn.1671-2420.2017.01.014

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