异种（牛）脱细胞真皮基质修复膜在耳鼻咽喉头颈外科术后缺损修复的应用

山东大学耳鼻喉眼学报

异种（牛）脱细胞真皮基质修复膜在耳鼻咽喉头颈外科术后缺损修复的应用

孙岩，张庆泉，张华，宋西成，赵利敏，王艳，姜绍红，王强

青岛大学医学院附属烟台毓璜顶医院耳鼻咽喉-头颈外科，山东烟台 264000

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2008-08-16 发布日期:2008-08-16
通讯作者: 孙岩

Heterogenerty (cattle) acellular dermal matrix repairing mucosa in otolaryngology reconstruction surgeries

SUN Yan， ZHANG Qing-quan， ZHANG Hua, SONG Xi-cheng, ZHAO Li-min,WANG Yan, JIANG Shao-hong, WANG Qiang

Department of Otorhinolaryngology & Head and Neck Surgery, Yuhuangding Hospital, Medical College of Qingdao University, Yantai 264000, Shandong, China

Received:1900-01-01 Revised:1900-01-01 Online:2008-08-16 Published:2008-08-16
Contact: SUN Yan

摘要/Abstract

摘要：

目的〓〖HTK〗探讨异种（牛）脱细胞基质修复膜在耳鼻咽喉头颈外科术后缺损修复的临床效果。〖HTW〗方法〓〖HTK〗利用修复膜对64例患者术后缺损进行一期修复，其中非肿瘤疾病11例，头颈部肿瘤53例。所有患者术后根据局部分泌物、脓液培养及药敏结果应用敏感抗生素，同时给予对症处理，保持修复膜湿润，咽喉肿瘤及颈段食道癌的患者进行鼻饲，不过早经口进食。〖HTW〗结果〓〖HTK〗所有患者出院时经检查，60例皮肤或黏膜缺损修复一期愈合；下咽癌、喉癌各1例患者术后出现咽漏，经局部换药对症处理后愈合；1例喉癌患者术后出现喉漏，经局部换药对症处理后愈合。均未发现排斥、过敏等反应。〖HTW〗结论〓〖HTK〗异种(牛)脱细胞真皮基质修复膜为修复耳鼻咽喉头颈外科术后的缺损提供了一种新的方法，手术操作简便，效果良好。

关键词: 异种, 脱细胞真皮基质, 黏膜缺损, 皮肤缺损, 修复外科手术

Abstract:

Objective〓〖WTBZ〗To explore the clinical effect of heterogeneity (cattle) acellular deunal matrix in mucosa defect repair in otolaryngology surgeries.
〖WTHZ〗Methods〓〖WTBZ〗64 cases of mucosa defect were treated with heterogeneity acellular deunal matrix, 53 of them were neoplasms. After the operations, patients were given antibiotics based on secretions or pus, also the acellular dermis should be kept moist and patients with neck esophageal squamous carcinoma or hypopharynx and larynx carcinoma received nasal feeding. 〖WTHZ〗Results〓〖WTBZ〗60 cases were healed. 1 case of hypopharynx and 1 of larynx carcinoma infected by pharynx fistula, and 1 case of larynx carcinoma infected by larynx fistula were healed after dressing change and expectant treatment. No exclusiveness and irritation were found during the treatments. 〖WTHZ〗Conclusion〓〖WTBZ〗Heterogeneity acellular deunal matrix is easily obtained and is effective in repairing mucosa defects.

Key words: Acellular deunal matrix, Mucosa defect,

Heterogeneity, Skin defect, Reconstruction surgery

中图分类号:

R762

孙岩,张庆泉,张华,宋西成,赵利敏,王艳,姜绍红,王强 . 异种（牛）脱细胞真皮基质修复膜在耳鼻咽喉头颈外科术后缺损修复的应用[J]. 山东大学耳鼻喉眼学报, 2008, 22(4): 316-319 .

SUN Yan,ZHANG Qing-quan,ZHANG Hua,SONG Xi-cheng,ZHAO Li-min,WANG Yan,JIANG Shao-hong,WANG Qiang . Heterogenerty (cattle) acellular dermal matrix repairing mucosa in otolaryngology reconstruction surgeries[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(4): 316-319 .

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