山东大学耳鼻喉眼学报 ›› 2017, Vol. 31 ›› Issue (3): 91-94.doi: 10.6040/j.issn.1673-3770.0.2016.392

• 论著 • 上一篇    下一篇

喉鳞癌组织中抑癌基因Maspin和转录因子Ets1的表达及意义

安永明1,穆文利2a,田艳勋3,李伟2b,吴彦桥4   

  1. 1.张家口建国医院耳鼻咽喉科, 河北 张家口 075000;
    2.解放军第251医院 a. 消化内科;
    b. 病理科, 河北 张家口 075000;
    3.邢台市人民医院耳鼻咽喉科, 河北 邢台 054000;
    4.白求恩国际和平医院耳鼻咽喉科, 河北 石家庄 050000
  • 收稿日期:2016-09-07 出版日期:2017-06-16 发布日期:2017-06-16

The significance of Maspin and Ets1 in laryngeal squamous carcinoma.

AN Yongming1, MU Wenli2a, TIAN Yanxun3, LI Wei2b, WU Yanqiao4   

  1. 1. Department of Otolaryngology, Jianguo Hospital of Zhangjiakou, Zhangjiakou 075000, Hebei, China;2a. Department of Gastroenterology, 2b. Department of Pathology, The 251st Hospital of Chinese PLA, Zhangjiakou 075000, Hebei, China;3. Department of Otolaryngology, Peoples Hospital of Xingtai, Xingtai 054000, Hebei, China;4. Department of Otolaryngology, Bethune International Peace Hospital, Shijiazhuang 050000, Hebei, China
  • Received:2016-09-07 Online:2017-06-16 Published:2017-06-16

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摘要： 目的 探讨在喉鳞癌组织中抑癌基因Maspin和转录因子Ets1的表达及意义。 方法 采用免疫组织化学(EnVisionTM)法检测70例手术切除的喉鳞状细胞癌组织及30例癌旁组织中Maspin、Ets1的表达。 结果 Maspin、Ets1在喉鳞状细胞癌组织中和癌旁组织中的阳性表达率差异有统计学意义(P<0.05);Maspin的阳性表达率与肿瘤直径、组织学分级、TNM分期及增殖活性Ki-67相关(P<0.05);Ets1的阳性表达率与组织学分级、TNM分期、淋巴结转移及增殖活性Ki-67相关(P<0.05)。Maspin、Ets1在喉鳞状细胞癌组织中的表达呈负相关性(P<0.01)。 结论 Maspin、Ets1共同参与了喉鳞状细胞癌的发生、发展,其表达反映了喉鳞状细胞癌的恶性程度,有利于进一步阐述喉鳞状细胞癌演变的相关机制。

关键词: 喉鳞状细胞癌, Ets1, 免疫组织化学, Maspin

Abstract: Objective To investigate the significance of Maspin, an anti-oncogene, and the transcription factor Ets1 in laryngeal squamous carcinoma. Methods The expression of Maspin and Ets1 was evaluated in 70 samples of laryngeal squamous carcinoma and 30 samples of non-cancerous adjacent tissues by immunohistochemistry(EnVisionTM, Fuzhou Mai Xin Biological Ltd. Co., China). Results The difference in the positive rates of expression of Maspin and Ets1 between the laryngeal squamous carcinoma and adjacent samples was statistically significant(P<0.05)Positive expression of Maspin was associated with tumor size, histological classification, TNM staging, and Ki-67 expression(P<0.05). Additionally, positive expression of Ets1 was associated with histological classification, TNM staging, lymph node metastasis, and Ki-67 expression(P<0.05). However, there was negative correlation between the expression of Maspin and Ets1 in laryngeal squamous carcinoma. Conclusion Maspin and Ets1 are involved in the progression of laryngeal squamous carcinoma; their expression not only reflects the malignant degree of laryngeal squamous carcinoma, but also is helpful in further expounding related mechanisms in the development of laryngeal squamous carcinoma.

Key words: Ets1, Immunohistochemistry, Maspin, Laryngeal squamous carcinoma

中图分类号: 

  • R739.65
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