热休克蛋白72在青光眼视网膜神经节细胞中的保护机制研究进展

doi:10.6040/j.issn.1673-3770.0.2021.147

摘要/Abstract

摘要： 青光眼是以不可逆性、进行性视功能损害为特征的视神经退行性病变。研究认为,保护视网膜神经节细胞,使视神经免于继续受损已成为青光眼研究的重点。热休克蛋白72(HSP72)是热休克蛋白家族重要成员之一,是凋亡的抑制者,与神经保护有密切关系。研究HSP72在青光眼视网膜神经节细胞中的抗凋亡和细胞保护特性,对青光眼发病机制的理论研究和临床治疗具有重要的指导意义。就HSP72在青光眼视网膜神经节细胞中的保护作用进行综述。

关键词: 热休克蛋白72, 青光眼, 视网膜神经节细胞, 保护机制

Abstract: Glaucoma is a degenerative optic neuropathy, and is characterized by irreversible and progressive visual impairment. The protection of retinal ganglion cells from further damage of optic nerve has become the focus of glaucoma research. HSP72 is one of the important members of heat shock protein family. It is an inhibitor of apoptosis and has a close relationship with neuroprotection. Studies on the anti-apoptotic and cytoprotective properties of HSP72 in glaucoma retinal ganglion cells have important guiding significance for theoretical research and clinical treatment of the pathogenesis of glaucoma. This article reviews the protective effects of HSP72 in glaucomatous retinal ganglion cells.

Key words: HSP72, Glaucoma, Retinal ganglion cells, Protection mechanism

中图分类号:

R775.9

赵颖,张珊综述许家骏,赵静如审校. 热休克蛋白72在青光眼视网膜神经节细胞中的保护机制研究进展[J]. 山东大学耳鼻喉眼学报, 2022, 36(5): 83-87.

ZHAO Ying, ZHANG ShanOverview,XU Jiajun, ZHAO JingruGuidance. Research progress on the protective mechanism of heat shock protein 72 in glaucoma retinal ganglion cells[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(5): 83-87.

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