铬对大鼠听力的损伤及锌、硒的拮抗作用

山东大学耳鼻喉眼学报 ›› 2011, Vol. 25 ›› Issue (3): 37-40.

铬对大鼠听力的损伤及锌、硒的拮抗作用

杨燕1，李宁2，于江2，张珂2，吴淑荣2，高希宝2

1.山东大学齐鲁医院耳鼻咽喉-头颈外科; 2.山东大学公共卫生学院卫生检验研究所，济南 250012

收稿日期:2011-01-19 修回日期:2011-02-11 出版日期:2011-06-16 发布日期:2011-06-16
通讯作者: 高希宝，男，博士，教授，硕士生导师，主要从事卫生检验方面的研究工作。 Email:chem@sdu.edu.cn
作者简介:杨燕，女，主管护师,山东大学在读公共卫生硕士。Email:y-y-2004@sina.com
基金资助:
_-

Auditory changes caused by chromium and antagonistic effects of zinc or selenium

YANG Yan1, LI Ning2, YU Jiang2, ZHANG Ke2, WU Shu-rong2, GAO Xi-bao2

1. Department of Otolaryngology and Head & Neck Surgery, Qilu Hospital of Shandong University;
2. Institute of Hygienic Inspection， School of Public Health, Shandong University, Jinan 250012, China

Received:2011-01-19 Revised:2011-02-11 Online:2011-06-16 Published:2011-06-16

摘要/Abstract

摘要：

目的研究铬中毒对大鼠听力功能的损伤以及锌、硒对铬中毒大鼠听力的保护作用。方法将40只雌雄各半的Wistar大鼠随机分成对照组(A)、铬染毒组(B)、锌(染铬)保护组(C)、硒(染铬)保护组(D)4组，连续灌胃30d后，通过脑干电诱发电位测定大鼠听力功能。结果与A组相比，B组听觉脑干电诱发电位图(ABR)极为平缓，其Ⅰ、Ⅱ波潜伏期明显延长,波峰幅度明显降低；C组大鼠ABR两波潜伏期短于B组，D组大鼠ABR两波潜伏期明显短于B组而高于A组，C、D两组的两波波峰明显高于B组而低于A组。结论铬中毒对大鼠听力造成一定伤害，锌、硒对这种伤害具有一定的保护作用，硒对铬中毒听力损伤的保护作用强于锌。

关键词: 铬中毒；听力损伤；锌；硒；拮抗作用

Abstract:

Objective To study chromium induced hearing damages and protective effects of zinc and selenium on hearing in rats. Methods Twenty male and twenty female Wistar rats were randomly and averagely divided into the control group(A), the chromium poisoning group(B), the zinc protective group(C), and the selenium protective group(D). After 30 days of oral administration of physiological saline, 4mg/kg potassium dichromate, 2mg/kg zinc sulfate, and 2mg/kg sodium selenite, their auditory brainstem response (ABR) was detected. Results ABR figures of chromium poisoning groups were extremely flat and theⅠand Ⅱ latencies of ABR waves were much longer and their wave peaks were much lower than those of the control group. TheⅠand Ⅱ latencies of the two ABR waves in group C were a little shorter than those of group B, and the latencies of group D were much shorter than those of group B, but both of them were still longer than those of group A. The two wave peaks of group C and group D were higher than those of group B but lower than those of group A. Conclusions Hearing functions of rats might be partly damaged by chromium and zinc or selenium shows some protective effects. The protection of selenium is stronger than that of zinc.

Key words: Chromium poisoning; Hearing damages; Zinc; Selenium; Antagonistic effect

中图分类号:

R764.5

杨燕1，李宁2，于江2，张珂2，吴淑荣2，高希宝2. 铬对大鼠听力的损伤及锌、硒的拮抗作用[J]. 山东大学耳鼻喉眼学报, 2011, 25(3): 37-40.

YANG Yan1, LI Ning2, YU Jiang2, ZHANG Ke2, WU Shu-rong2, GAO Xi-bao2. Auditory changes caused by chromium and antagonistic effects of zinc or selenium[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(3): 37-40.

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