突发聋和梅尼埃病鼓室灌注疗效与内耳MRI显影相关性

山东大学耳鼻喉眼学报 ›› 2011, Vol. 25 ›› Issue (4): 38-40.

突发聋和梅尼埃病鼓室灌注疗效与内耳MRI显影相关性

吴佳欐1，陈文文1，罗禹2，童军1，邓亚新1，单良1，方旭华1

上海交通大学附属上海市第一人民医院分院 1.耳鼻喉科； 2.放射科，上海 200081

收稿日期:2011-05-03 修回日期:2011-06-09 出版日期:2011-08-16 发布日期:2011-08-16
通讯作者: 陈文文。 Email: chenww50@hotmail.com
作者简介:吴佳欐(1979- )，女，主治医师，主要从事耳鼻咽喉科临床显微手术治疗研究。
基金资助:
上海市虹口区卫生局科研基金立项资助(0904-08)。

Relationship of trans-tympanic administration effect with inner ear MRI visualization in patients with Meniere′s disease and idiopathic sudden hearing loss

WU Jiali1， CHEN Wenwen1， LUO Yu2， TONG Jun1， DENG Yaxin1， SHAN Liang1， FANG Xuhua1

1. Department of Otolaryngology； 2. Department of Radiology， Branch of Shanghai First People′s Hospital Affiliated to Shanghai Jiao Tong University， Shanghai 200081， China

Received:2011-05-03 Revised:2011-06-09 Online:2011-08-16 Published:2011-08-16

摘要/Abstract

摘要：

目的研究突发聋和梅尼埃病鼓室灌注疗效与内耳MRI显影的相关性。方法 17例患者(突发聋13例，梅尼埃病4例)给予鼓室插管并注射钆造影剂，术后1h、1d、6d行MRI连续扫描，1周后复查电测听，评估眩晕改善情况，分析钆剂是否透入内耳和症状改善的相关性。结果 17例中9例(突发聋5例，梅尼埃病4例)在插管注入钆剂后1h到6d的MRI检查中出现内耳高信号。另8例MRI未显影者听力没有进步。结论鼓室灌注造影剂能透入内耳者药物也能透入，治疗效果亦较好。

关键词: 内耳；鼓室灌注；梅尼埃病；聋，突发性

Abstract:

Objective To explore and analyze the relationship of transtympanic administration effect with inner ear MRI visualization in patients with Meniere′s disease and idiopathic sudden hearing loss. Methods 17 cases (13 cases of idiopathic sudden hearing loss and 4 cases of Meniere′s disease)were enrolled in the study. Gadolium, dexamethason or gentimycin were transtympanically injected, and all patients were scanned with MRI 1h， 1d， and 6d after operation. The relationship of the effect with MRI visualization was observed and analyzed. Results 9 cases(5 cases of idiopathic sudden hearing loss and 4 cases of Meniere′s disease) of the 17 had inner ear high signal 1h to 6d after gadolium was injected. The other 8 cases had neither signal in the inner ear nor improved hearing. Conclusion If transtympanically injected gadolium can permeate into the inner ear, dexamethoson and gentimycin would also permeate into it, and the therapy would have a good effect.

Key words: Inner ear；Transtympanic infuse； Meniere′s desease；Deafness，sudden

中图分类号:

R764.437

吴佳欐1，陈文文1，罗禹2，童军1，邓亚新1，单良1，方旭华1. 突发聋和梅尼埃病鼓室灌注疗效与内耳MRI显影相关性[J]. 山东大学耳鼻喉眼学报, 2011, 25(4): 38-40.

WU Jiali1， CHEN Wenwen1， LUO Yu2， TONG Jun1， DENG Yaxin1， SHAN Liang1， FANG Xuhua1. Relationship of trans-tympanic administration effect with inner ear MRI visualization in patients with Meniere′s disease and idiopathic sudden hearing loss[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(4): 38-40.

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