阿司匹林耐受不良三联征的临床特点

山东大学耳鼻喉眼学报 ›› 2012, Vol. 26 ›› Issue (3): 45-47.

阿司匹林耐受不良三联征的临床特点

王长青1,李新平1,赵文敏1，王忠1，曾鸿斌1，张华1，刘立中2

1. 西双版纳州人民医院耳鼻咽喉科，云南西双版纳 666100；2.新疆医科大学第一临床医学院耳鼻咽喉科，
乌鲁木齐 830054

收稿日期:2011-10-06 出版日期:2012-06-16 发布日期:2012-06-16
作者简介:王长青，硕士。 Email:wcq51888@sina.com

Analysis and research of clinical features of aspirin intolerance triad

WANG Chang-qing1, LI Xin-ping1, ZHAO Wen-min1, WANG Zhong1, ZENG Hong-bin1, ZHANG Hua1, LIU Li-zhong2.

1. Department of Otorhinolaryngology, Xishuangbanna Pepole′s Hospital, Xishuangbanna 666100, Yunnan, China; 2. Department of Otorhinolaryngology, The First Teaching Hospital of Xinjiang Medical University, Urumuqi 830054, China

Received:2011-10-06 Online:2012-06-16 Published:2012-06-16

摘要/Abstract

摘要：

目的探讨阿司匹林耐受不良三联征(aspirin intolerance triad,AIT)的临床特点，以提高诊治及预防水平。方法采用回顾性研究的方法，对新疆医科大学一附院收治的35例AIT患者临床资料并结合文献进行分析。结果本组男13例(37%)，女22例(63%)，男女比例约0.59∶1；21～69岁，平均(36±16)岁。不耐受药物种类中：水杨酸类25例，占71%；丙酸类2例,占6%；吡唑酮类8例，占23%；灭酸类、昔康类、昔布类均无。临床类型中：鼻炎基础型11例，占32%；阿司匹林耐受不良基础型19例，占54%；哮喘基础型5例，占14%。本组25例行鼻窦CT检查显示鼻窦炎以多发或全组为主。本组23例行功能性内镜鼻窦手术获得临床治愈，术后鼻息肉行病检，水肿型13例，占57%，腺囊泡型6例，占26%，纤维型4例，占17%；12例予以抗炎、平喘治疗好转出院。结论 AIT患者症状较重，积极预防、早期诊断、合理治疗可减少AIT患者严重并发症的发生，提高生活质量。

关键词: 阿司匹林三联征；阿司匹林耐受不良；鼻息肉；支气管哮喘

Abstract:

Objective To investigate clinical characteristics and improve the level of diagnosis, treatment and prevention in patients with aspirin intolerance triad. Methods A retrospective study of the clinical data and analysis of literature was performed on 35 cases of AIT(aspirin intolerance triad). ResultsT here were 13 males(37%) and 22 females(63%) with a ratio of 0.59∶1(M∶F). The age ranged from 21 years to 69 years (average 36±16 years). In view of the type of drug intolerance, 25 cases were the salicylic acid-type, accounting for 71%, mainly to aspirin; 2 cases the propionic acid-type, accounting for 6%, mainly to naproxen; 8 cases the pyrazole ketones, accounted for 23%, mainly to analgin; and no anti-acid, oxicams, or coxibs. In clinical type: 11 cases were the rhinitis foundation, accounting for 32%; 19 cases the asthma starts, accounting for 54%; and 5 cases the asthma foundation, accounting for 14%(37%). 25 cases had CT examination which revealed a regular sinus sinusitis or whole multiple group-oriented. 23 had FESS were routinely cured, pathological examination of 13 cases (57%) showed dropsy , 6 cases (26%) gland pouch soak, and 4 cases(17%) textile fiber. The other 12 cases were discharged with improvement after anti-inflammatory and anti-asthmatic treatment. Conclusion Early prevention, diagnosis, and rational treatment are helpful in improving the diagnosis and treatment of AIT.

Key words: Aspirin intolerance triad; Aspirin intolerance; Nasal polyps; Asthma

中图分类号:

R765.21

王长青1,李新平1,赵文敏1，王忠1，曾鸿斌1，张华1，刘立中2 . 阿司匹林耐受不良三联征的临床特点[J]. 山东大学耳鼻喉眼学报, 2012, 26(3): 45-47.

WANG Chang-qing1, LI Xin-ping1, ZHAO Wen-min1, WANG Zhong1, ZENG Hong-bin1, ZHANG Hua1, LIU Li-zhong2.. Analysis and research of clinical features of aspirin intolerance triad[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2012, 26(3): 45-47.

参考文献

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