原发性开角型青光眼患者血清miR-29b差异性表达

doi:10.6040/j.issn.1673-3770.0.2012.380

山东大学耳鼻喉眼学报 ›› 2013, Vol. 27 ›› Issue (6): 79-81.doi: 10.6040/j.issn.1673-3770.0.2012.380

原发性开角型青光眼患者血清miR-29b差异性表达

翟玉喜，高建鲁

聊城市人民医院泰山医学院聊城临床学院眼科，山东聊城 252000

收稿日期:2012-12-21 发布日期:2013-12-16
通讯作者: 高建鲁。 Email：gaojianlu1964@gmail.com
作者简介:翟玉喜。 Email：zhaiyuxi1986@sina.com
基金资助:
山东省自然科学基金(ZR2012HM019)

Different expression of miR-29b in serum of primary open-angle glaucoma patients

ZHAI Yu-xi, GAO Jian-lu

Department of Ophthalmology, Liaocheng Clinical School, Taishan Medical College, Liaocheng People′s Hospital, Liaocheng 252000, Shandong, China

Received:2012-12-21 Published:2013-12-16

摘要/Abstract

摘要：

目的检测散发原发性开角型青光眼(POAG)患者血清miR-29b表达，探讨miR-29b在分子水平致病机制中的作用。方法通过qRT-PCR技术检测并比较20例散发POAG患者及20例健康对照者血清miR-29b表达的差异性。结果散发POAG组血清miR-29b相对表达量是健康对照组的0.15倍，差异有统计学意义(P=0.03)。结论散发POAG组血清miR-29b表达较健康对照组明显下调，提示miR-29b在POAG致病机制中可能起重要作用。

关键词: 原发性开角型青光眼, 细胞外基质, miR-29b

Abstract:

Objective To test the expression of miR-29b in primary open-angle glaucoma(POAG) patients′ serum and discuss its function in the pathogenesis of POAG. Methods qRT-PCR was used to detect the expression of miR-29b both in 20 sporadic POAG patients and 20 healthy people. The results were compared. Results The expression of miR-29b in sporadic POAG patients was 0.15times the value of healthy group. The difference was statistically significant(P=0.03). Conclusion The expression of miR-29b in sporadic POAG patients′ serum was significantly downregulated， which indicated that miR-29b may play an important role in the pathogenesis of POAG.

Key words: Extracellular matrix, MicroRNA-29b, Primary open-angle glaucoma

中图分类号:

R775.2

翟玉喜，高建鲁. 原发性开角型青光眼患者血清miR-29b差异性表达[J]. 山东大学耳鼻喉眼学报, 2013, 27(6): 79-81.

ZHAI Yu-xi, GAO Jian-lu. Different expression of miR-29b in serum of primary open-angle glaucoma patients[J]. J Otolaryngol Ophthalmol Shandong Univ, 2013, 27(6): 79-81.

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原发性开角型青光眼患者血清miR-29b差异性表达

Different expression of miR-29b in serum of primary open-angle glaucoma patients

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