山东大学耳鼻喉眼学报 ›› 2014, Vol. 28 ›› Issue (5): 34-37.doi: 10.6040/j.issn.1673-3770.0.2014.227

• 论著 • 上一篇    下一篇

舌下含服粉尘螨滴剂联合鼻用激素治疗变应性鼻炎疗效观察

谢晓红1,4, 胡志邦2, 宋盼盼2, 戴艳红3, 陈峰3, 俞晨杰3, 高下1,2,3   

  1. 1. 南京大学医学院, 江苏 南京 210008;
    2. 南京医科大学鼓楼临床医学院耳鼻咽喉头颈外科, 江苏 南京 210008;
    3. 南京大学医学院附属鼓楼医院耳鼻咽喉头颈外科, 江苏 南京 210008;
    4. 南京明基医院耳鼻咽喉头颈外科, 江苏 南京 210019
  • 收稿日期:2014-07-08 发布日期:2014-10-16
  • 通讯作者: 高下。E-mail：xiagaogao@hotmail.com E-mail:xiagaogao@hotmail.com
  • 作者简介:谢晓红。E-mail:15861808899@139.com

Clinical efficacy of sublingual dermatophagoides farinae drops in combination with intranasal steroids in treatment of allergic rhinitis

XIE Xiao-hong1,4, HU Zhi-bang2, SONG Pan-pan2, DAI Yan-hong3, CHEN feng3, YU Chen-jie3, GAO Xia1,2,3   

  1. 1. Medical School of Nanjing University, Nanjing 210008, Jiangsu, China;
    2. Department of Otolaryngology, the Drum Tower Clinical Medical College of Nanjing Medical University, Nanjing 210008, Jiangsu, China;
    3. Department of Otolaryngology, the Affiliated Drum Tower Hospital of Nanjing University Medical College, Nanjing 210008, Jiangsu, China;
    4. Department of Otolaryngology, BenQ Medical Center, Nanjing Medical University, Nanjing 210019, Jiangsu, China
  • Received:2014-07-08 Published:2014-10-16

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摘要： 目的 评估舌下特异性免疫治疗联合鼻用激素治疗变应性鼻炎的疗效。方法 将能坚持治疗并定期随访的90例对粉尘螨过敏的变应性鼻炎患者资料纳入研究，随机分为两组，其中60例接受舌下免疫治疗(SLIT)联合鼻用激素治疗，另30例只用鼻用激素治疗，分别记录两组患者治疗前及治疗后6、12个月的症状评分(鼻痒、喷嚏、流涕、鼻塞症状评分)和症状总评分。结果 两组治疗后鼻炎症状均有显著改善，差异有统计学意义(P<0.05)；联合治疗组12个月后较治疗6个月后鼻炎症状改善更显著(P<0.05)，而单用激素组未再有明显改善(P>0.05)；联合治疗组较单用激素组无论6个月后还是12个月后症状改善均更为显著(P<0.05)。结论 舌下特异性免疫治疗联合鼻用激素治疗变应性鼻炎较单用激素更为有效。

关键词: 变应性, 舌下特异性免疫治疗, 粉尘螨, 鼻炎, 鼻用激素

Abstract: Objective To evaluate the clinical efficacy of sublingual immunotherapy(SLIT) in the treatment of allergic rhinitis in combination with intranasal steroids. Methods Ninety AR patients were randomly divided into two groups: 60 patients treated by SCIT+steroids and the other 30 patients only treated with intranasal steroids. The nasal symptom scores of pruritus, sneezing, rhinorrhea and nasal obstruction were evaluated using a four-point raiting scale (from 0=absent to 3=severe) before the treatment and six months and a year after the treatment. Then the scores were compared. Results The nasal symptom scores of all patients were significantly decreased after treatment(P<0.05), and the symptoms after treatment were alleviated more significantly after one year than after 6 months in the combination group(P<0.05). However, there were no significant difference between the two periods in the single nasal spray group (P>0.05). The scores of nasal symptom in the combination group were significant lower than the single nasal spray group whether after 6 months or after 12 months. Conclusion Combination therapy of SLIT and intranasal steroids is more effective for allergic rhinitis than intranasal steroids alone.

Key words: Rhinitis, allergic, Intranasal steroids, Dust mite, Sublingual immunotherapy

中图分类号: 

  • R765.2
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