山东大学耳鼻喉眼学报 ›› 2015, Vol. 29 ›› Issue (1): 15-18.doi: 10.6040/j.issn.1673-3770.0.2014.284

• 论著 • 上一篇    下一篇

鼓室激素注射为初始治疗的突发性聋听力恢复的时间规律

张彩霞1,2, 刘阳云2, 陈志喜3, 江文2, 李正贤2, 陈琼2, 常恩格2   

  1. 1. 湖南师范大学医学院, 湖南 长沙 410003;
    2. 湖南师范大学医学院第二附属医院/解放军第163中心医院耳鼻喉科, 湖南 长沙 410003;
    3. 粤北人民医院耳鼻咽喉头颈外科, 广东 韶关 512026
  • 收稿日期:2014-08-25 出版日期:2015-02-16 发布日期:2015-02-16
  • 通讯作者: 刘阳云。E-mail:lyyundr@aliyun.com E-mail:lyyundr@aliyun.com
  • 作者简介:张彩霞。E-mail:1309642400@qq.com

Time pattern of audiological recoverey with intratympanic steroid injection as primary treatment for sudden sensorineural hearing loss

ZHANG Cai-xia1 2, LIU Yang-yun2, CHEN Zhi-xi3, JIANG Wen2, LI Zheng-xian2, CHEN Qiong2, CHANG En-ge2   

  1. 1. The Medical College of Hunan Normal University, Changsha 410003, Hunan, China;
    2. Department of Otolaryngology, the Second Affiliated Hospital of Hunan Normal University Medical College(No. 163 Hospital of PLA), Changsha 410003, Hunan, China;
    3. Department of Otolaryngology & Head and Neck Surgery, Yuebei People's Hospital, Shaoguan 512026, Guangdong, China
  • Received:2014-08-25 Online:2015-02-16 Published:2015-02-16

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摘要： 目的 探讨鼓室激素注射作为初始治疗突发性聋患者方案的听力恢复时间规律,寻求最佳鼓室给药时机。方法 将突发性聋患者135例纳入研究,均接受为期2周的全身激素治疗。其中63例仅接受全身激素治疗,另72例在全身激素治疗开始的同时联合鼓室内激素注射。所有病例随访2个月。结果 治疗后第3天、第7天、第14天、1个月、2个月每个时间点两组间总有效率差异均无统计学意义。全身激素治疗联合鼓室注射组第7天与第14天疗效差异无统计学意义(P=0.065),而单纯全身激素治疗者第7天与第14天疗效比较差异有统计学意义(P=0.029)。结论 鼓室激素注射联合全身激素治疗作为初始治疗方案,其疗效并不优于单纯全身激素治疗,但听力改善峰值的时间前者总体早于后者。

关键词: 恢复时间规律, 鼓室注射, 时机, 突发性聋

Abstract: Objective To explore the time pattern of audiological recovery with intratympanic steroid injection as primary treatment for sudden sensorineural hearing loss (SSNHL) to define best strategy. Methods All 135 patients underwent a two-week systemic steroid therapy, while 72 of them received extra intratympanic injection in the mean time. All cases were followed up 2 months. Results No difference in total effective rates between the two treatments on 3rd day, 7th day,14th day and 1 month was noted. There was no difference between the 7th day and 14th day in combined treatment was noted (P=0.065) but not in systemic steroid therapy alone(P=0.029). Conclusion As a primary treatment, the curative effects between the intratympanic steroid administration and systemic steroid therapy shows no difference. The peaked time of hearing improvement of the former is earlier than that of the latter.

Key words: Intratympanic steroid injection, Time pattern of audiological recovery, Sudden sensorineural hearing loss (SSNHL), Primary treatment

中图分类号: 

  • R764.43
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