山东大学耳鼻喉眼学报 ›› 2015, Vol. 29 ›› Issue (5): 62-64.doi: 10.6040/j.issn.1673-3770.0.2015.167

• 论著 • 上一篇    下一篇

南京地区急性细菌性结膜炎的最新致病菌分析

赵太宏, 李中国   

  1. 南京医科大学附属南京医院 南京市第一医院眼科, 江苏 南京 210006
  • 收稿日期:2015-04-23 修回日期:2015-09-22 出版日期:2015-10-16 发布日期:2015-10-16
  • 作者简介:赵太宏,E-mail:zhao.eye@163.com

Pathogens of acute bacterial conjunctivitis in Nanjing area

ZHAO Taihong, LI Zhongguo   

  1. Department of Ophthalmology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, Jiangsu, China
  • Received:2015-04-23 Revised:2015-09-22 Online:2015-10-16 Published:2015-10-16

PDF (PC)

516

被引次数

1

摘要： 目的 了解南京地区急性细菌性结膜炎的致病菌分布情况,为有效治疗本病提供参考。方法 选取符合纳入标准的96眼急性细菌性结膜炎的结膜囊分泌物进行病原学检测,同时予以加替沙星滴眼液滴眼,每日4次,连续治疗1周,再次取分泌物进行病原学检查,并进行对比分析。结果 86眼均成功采集结膜囊分泌物。首次病原学检测阳性率为81.25%,其中革兰阴性细菌占15.63%,以大肠埃希菌及肺炎克雷伯菌为主;而革兰阳性细菌占65.63%,其中位居前三的分别为表皮葡萄球菌50眼(52.08%),金黄色葡萄球菌7眼(7.29%),腐生葡萄球菌3眼(3.13%)。治疗1周后,患者临床症状均治愈,再次行病原学检查,仍有11眼阳性,表皮葡萄球菌7眼(8.14%),金黄色葡萄球菌4眼(4.65%),67眼(77.92%)转为阴性。结论 葡萄球菌尤其以表皮葡萄球菌为主是南京地区急性细菌性结膜炎的主要致病菌,临床治疗本病应注意合理用药。

关键词: 细菌性结膜炎, 急性, 病原学检测

Abstract: Objective To investigate the pathogenic bacteria of acute bacterial conjunctivitis in Nanjing area and to provide reference for treatment. Methods Ninety-six eyes with acute bacterial conjunctivitis were enrolled in this study. Bacterial culture was performed on secretion specimens from conjunctival sac. Meanwhile, treatment with Gatifloxacin eye drops(4 times per day, 1 week) was carried out. After treatment, secretion specimens were re-cultivated. Results Secretion specimens of 86 eyes were successfully collected and cultivated two times. The positive rate was 81.25% in the first time. The percentages of gram positive bacteria (the top three: Staphylococcus epidermidis 52.08%, Staphylococcus aureus 7.29% and Staphylococcus saprophyticus 3.13%) and Gram negative bacteria (Escherichia coli and Klebsiella pneumoniae) in the bacteria were 65.63% and 15.63% respectively. No eye symptoms were observed after the treatment. For the second cultivation, 67 eyes(77.92%) turned to negative, 7 eyes(8.14%) were with Staphylococcus epidermidis and 4 eyes(4.65%) with Staphylococcus aureus. Conclusion The main pathogenic bacterium in acute bacterial conjunctivitis in Nanjing Area is Staphylococcus epidermidis, which should be paid attention in clinical treatment.

Key words: Acute, Bacterial conjunctivitis, Etiology detection

中图分类号: 

  • R77
[1] 惠延年. 眼科学[M]. 5版.北京:人民卫生出版社,2001:67.
[2] 张伦占. 临床治疗细菌性结膜炎124例的经验总结[J].国际眼科杂志, 2014,14(10):1908-1910. ZHANG Lunzhan. Clinical experience summary of bacterial conjunctivitis treatment in 124 cases[J]. Inter Eye Sci, 2014, 14(10):1908-1910.
[3] Hwang D G, Schanzlin D J, Rotberg M H, et al. Levofloxacin Bacterial Conjunctivitis Place. controlled Study Group. A phaseⅢ. Placebo controlled clinical trial of 0.5% levofloxacin ophthalmic solution for the treatment of bacterial conjunctivitis[J]. Br J Ophthalmol, 2003, 87:1004-1009.
[4] Hivding G. Acute bacterial conjunctivitis[J]. Acta Ophthamlol, 2008, 86(1):5-17.
[5] 姜洋,金玉梅,罗岩,等.我国急性细菌性结膜炎最新病原学分析[J].眼科新进展, 2013, 33(4): 335-337. JIANG Yang, JIN Yumei, LUO Yan, et al. Etiological analysis of acute bacterial conjunctivitis in China[J]. Recent Adva Ophthalmol, 2013, 33(4):335-337.
[6] 王玉萍,张文芳,王多春,等. 兰州地区细菌性结膜炎的致病菌分布和耐药性分析[J].中国实用眼科杂志, 2011, 29(11):1159-1161. WANG Yuping, ZHANG Wenfang, WANG Duochun, et al. Distribution and drug resistance of pathogenic bacteria in bacterial conjunctivitis in Lanzhou area[J]. Chin J Prac Ophthalmol, 2011, 29(11):1159-1161.
[7] 张立贵,仇宜解,吕秀文,等.细菌性结膜角膜炎的病原菌分析[J].中国实用眼科杂志,1996,14(11):671-673. ZHANG Ligui, QIU Yijie, LV Xiuwen, et al. Analysis of pathogenic bacteria in bacterial and keratitis[J]. Chin J Prac Ophthalmol, 1996, 14(11):671-673.
[8] 黎明,姚晓明,周青,等.新生儿急性细菌性结膜炎10年致病菌变迁[J].中国实用眼科杂志,2011,29(3):287-293. LI Ming, YAO Xiaoming, ZHOU Qing, et al. The transition of bacterial pathogens in acute neonatal conjunctivitis in recent 10 years[J]. Chin J Prac Ophthalmol, 2011, 29(3):287-293.
[9] Adebayo A, Parikh J G, McCormick S A, et al. Shifting trends in in vitro antibiotic susceptibilities for common bacterial conjunctival isolates in the last decade at the New York Eye and Ear Infirmary[J]. Graefes Arch Clin Exp Ophthalmol, 2011, 249(1):111-119.
[10] Bharathi M J, Ramakrishnan R, Shivakumar C, et al. Etiology and antibacterial susceptibility pattern of community-acquired bacterial ocular infections in a tertiary eye care hospital in south India[J]. Indian J Ophthalmol, 2010, 58(6):497-507.
[11] Nayak N, Satpathy G, Nag H L, et al. Slim e production is essential for the adherence of Staphylococcus epidermidis in implant-related infections[J]. J Hosp Infect, 2011, 77(2):153-156.
[1] 王新萌,姬俊雅,于浩南,付鸿臣,王翔,郑泽坤,李艳,钟莹莹. 急性闭角型青光眼超声乳化联合房角分离术后屈光预测准确性分析[J]. 山东大学耳鼻喉眼学报, 2026, 40(2): 74-79.
[2] 丁术梁,王超凡,刘建亮. 眼内液检测指导精准治疗急性视网膜坏死1例并文献复习[J]. 山东大学耳鼻喉眼学报, 2025, 39(5): 114-117.
[3] 刘迪,王真真,关兵,朱斌. 扬州市区环境气象因素对急性会厌炎及扁桃体炎发病的影响[J]. 山东大学耳鼻喉眼学报, 2025, 39(4): 142-150.
[4] 申博珺,刘素茹,李春燕,苏开明. 探讨血清胆红素水平对急性会厌炎患者预后的影响[J]. 山东大学耳鼻喉眼学报, 2025, 39(3): 26-31.
[5] 潘佳煜,张春林. 急性低频感音神经性听力下降病因及发病机制的研究进展[J]. 山东大学耳鼻喉眼学报, 2025, 39(2): 126-131.
[6] 樊永将,黄卫,何成山,沈海涛,徐正,郝亚楠. SARS-CoV-2感染后成人急性分泌性中耳炎细胞因子水平分析[J]. 山东大学耳鼻喉眼学报, 2024, 38(2): 1-6.
[7] 李淑婷,赵慧,司明威,崔文轩,杨梦瑶,王红. 透明质酸鼻部填充致单眼视网膜中央动脉阻塞1例并文献复习[J]. 山东大学耳鼻喉眼学报, 2024, 38(1): 66-71.
[8] 李泽鹏,李文建,孙志佳. 中成药治疗急性咽炎数据挖掘及网状Meta分析[J]. 山东大学耳鼻喉眼学报, 2023, 37(4): 111-118.
[9] 余昪昪,陈颖,邓可斌,易新林,雷西熙,李辉,马欣. 肺炎支原体合并乙型流感病毒感染致急性化脓性扁桃体炎1例并文献复习[J]. 山东大学耳鼻喉眼学报, 2023, 37(3): 64-66.
[10] 赵雅铭,石崧. 以急性会厌炎为首诊的3例颈部坏死性筋膜炎病例报告并文献复习[J]. 山东大学耳鼻喉眼学报, 2021, 35(4): 12-16.
[11] 窦倩雯,田秀芬. 低温等离子射频消融治疗216例先天性梨状窝瘘的临床分析[J]. 山东大学耳鼻喉眼学报, 2021, 35(2): 39-45.
[12] 朱鲁平, 陈娟, 朱垒, 陈仁杰. 儿童急性鼻窦炎合并肾小球肾炎及眶内脓肿一例[J]. 山东大学耳鼻喉眼学报, 2019, 33(6): 41-44.
[13] 李鑫,吴玮,王刚,司少艳,韩浩伦,李保卫,范欣,张驰,尚颖,丁瑞英. 大气污染中气态污染物致大鼠喉黏膜急性损伤的研究[J]. 山东大学耳鼻喉眼学报, 2019, 33(6): 75-79.
[14] 岳鹏程,王园,万晓梅,宫华青. A型肉毒素显微注射治疗急性共同性内斜视的临床疗效分析[J]. 山东大学耳鼻喉眼学报, 2019, 33(2): 119-122.
[15] 杨耀玮,陆颖霞,谷庆隆. 2013~2017年北京地区儿童急性喉炎就诊特点及其与气象因素和空气污染物的相关性研究[J]. 山东大学耳鼻喉眼学报, 2019, 33(1): 88-93.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
网站版权所有 © 2018 《山东大学耳鼻喉眼学报》编辑部　
地址：山东省济南市山大南路27号（250100）电话：+86-0531-88366912 E-mail: ebhxb@sdu.edu.cn
本系统由北京玛格泰克科技发展有限公司设计开发