纤毛长度信号通路调节机制的研究进展

doi:10.6040/j.issn.1673-3770.0.2015.550

山东大学耳鼻喉眼学报 ›› 2016, Vol. 30 ›› Issue (2): 98-101.doi: 10.6040/j.issn.1673-3770.0.2015.550

纤毛长度信号通路调节机制的研究进展

王晶¹,王雪松²综述,薛金梅³审校

1.山西医科大学, 山西太原 030001;
2.滨州市中心医院耳鼻咽喉科, 山东滨州 251700;
3.山西医科大学第二医院耳鼻咽喉头颈外科, 山西太原 030001

收稿日期:2015-12-29 出版日期:2016-04-16 发布日期:2016-04-16
通讯作者: 薛金梅. E-mail:xjment@126.com E-mail:915304004@qq.co
作者简介:王晶. E-mail:915304004@qq.co
基金资助:
山西省自然基金(20130110552);山西省卫生厅青年项目资助(201201080)

Progress of intracellular signaling pathways regulating ciliary length.

WANG Jing¹, WANG Xuesong², XUE Jinmei

1. Shanxi Medical University, Taiyuan 030001, Shanxi, China;2. Department of Otolaryngology, Binzhou Central Hospital, Binzhou 251700, Shandong, China;3. Department of Otolaryngology, Second Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi, China

Received:2015-12-29 Online:2016-04-16 Published:2016-04-16

摘要/Abstract

摘要： 纤毛广泛分布于机体多种类型细胞表面,在体内发挥着重要的生理作用,其长度异常必定导致纤毛功能的异常,进而导致纤毛相关疾病;纤毛长度受到多种因素如纤毛内转运机制、细胞周期、相关基因及信号通路的影响,其中信号通路包括NF-κB、Wnt、Shh、Notch、第二信使等,了解纤毛长度信号调节机制对相关疾病的诊疗具有指导意义。

关键词: 纤毛, 信号通路, 纤毛长度

Abstract: Cilia are located on almost all cell types of the human body, and perform key tasks for a variety of organs, but defects in the length or function of them are involved in the pathogenesis of several cilia-related disorder.Ciliary length can be regulated by the process of intraflagellar transport(IFT), signal transduction pathways,cell cycle,etc.All of these stages are tightly regulated to produce a cilium of the right size at the right time.Signaling regulation involves cAMP, NF-κB, Wnt, Shh and Notch.To further explore intracellular molecules that regulate ciliary length is of great importance for the diagnosis and treatment of certain cilia-related disorder.

Key words: Ciliary length, Cilia, Signal pathways

中图分类号:

Q471

王晶,王雪松综述,薛金梅审校. 纤毛长度信号通路调节机制的研究进展[J]. 山东大学耳鼻喉眼学报, 2016, 30(2): 98-101.

WANG Jing, WANG Xuesong, XUE Jinmei. Progress of intracellular signaling pathways regulating ciliary length.[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(2): 98-101.

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纤毛长度信号通路调节机制的研究进展

Progress of intracellular signaling pathways regulating ciliary length.

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