糖皮质激素不同给药方式治疗突发性聋的临床疗效及安全性研究

doi:10.6040/j.issn.1673-3770.0.2018.408

摘要/Abstract

摘要： 目的观察糖皮质激素不同给药方式治疗突发性聋的临床疗效及安全性。方法将耳鼻喉科2017年1月至2018年3月收治的150例突发性聋患者按照住院顺序随机分为3组, 在应用改善微循环、营养神经药物治疗的基础上,鼓室穿刺组加用鼓室穿刺注射糖皮质激素,静脉滴注组加用静脉滴注糖皮质激素,耳后乳突组加用耳后乳突注射糖皮质激素。比较治疗后3组患者听力提高疗效及不良反应情况等。结果与治疗前相比,治疗2周后耳后注射糖皮质激素组疗效均优于静脉滴注糖皮质激素与鼓室穿刺注射糖皮质激素组,差异均有统计学意义(P<0.05)。3组不良反应及并发症比较,差异无统计学意义(P>0.05)。结论糖皮质激素耳后乳突区局部注射糖皮质激素治疗突发性聋的临床疗效更佳,不良反应发生率低,更安全可靠。

关键词: 突发性聋, 糖皮质激素, 耳后注射, 鼓膜穿刺, 临床疗效

Abstract: Objective The aim of the study was to investigate the clinical efficacy and safety of different methods of glucocorticoid administration in the treatment of sudden deafness. Methods One hundred and fifty patients with sudden deafness admitted in our hospital from January 2017 to March 2018 were randomly divided into three groups according to the hospitalization order. Based on the application of improved microcirculation methods, nutritional neuropharmacology, and tympanostomy, the groups were classified as tympanic glucocorticoid injection group, intravenous drip and intravenous infusion of glucocorticoid group, and postauricular mastoid group with postauricular mastoid injection of glucocorticoids. The improvement in hearing and adverse reactions of the three groups were compared after the completion of treatment. Results A comparison of the three groups before and after 2-weeks of hearing improvement treatment suggests that the effect of glucocorticoid injection in the postauricular mastoid region was better than intravenous infusion or tympanic injection of glucocorticoids, and the difference was observed to be statistically significant (P<0.05). However, no significant differences were observed in the rate of adverse reactions and complications among the three groups (P>0.05). Conclusion Glucocorticoid injection in the posterior mastoid area was found to be better for the treatment of sudden deafness. The incidence of adverse reactions is low, and, hence, the treatment can be deemed reliable and safe.

Key words: Sudden deafness, Corticosteroids, Postauricular injection, Tympanic membrane puncture, Clinical efficacy

中图分类号:

R764.437

张俊军,刘海莉,刘加福,秦小奉,杜洪明,王厚慧. 糖皮质激素不同给药方式治疗突发性聋的临床疗效及安全性研究[J]. 山东大学耳鼻喉眼学报, 2019, 33(4): 52-55.

ZHANG Junjun, LIU Haili, LIU Jiafu, QIN Xiaofeng, DU Hongming, WANG Houhui. Clinical efficacy and safety of different methods of administration of glucocorticoids in the treatment of sudden deafness[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(4): 52-55.

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