内耳上皮钠通道、水通道蛋白与内淋巴代谢相关性的研究进展

doi:10.6040/j.issn.1673-3770.0.2018.301

摘要/Abstract

摘要： 梅尼埃病的主要病理表现为膜迷路积水,但膜迷路积水的具体作用机制尚未完全明确。已有研究证实,膜迷路积水与内耳离子、水转运通道息息相关。对内耳上皮钠通道(ENaC)、水通道蛋白(AQPs)与内淋巴代谢相关性的研究进行综述,探讨膜迷路积水形成机制,为进一步研究梅尼埃病的发病机制和治疗提供科学依据。

关键词: 上皮钠通道, 水通道蛋白, 内淋巴代谢, 膜迷路积水

Abstract: Endolymphatic hydrops is the main pathological disorder in Meniere's disease, although the precise mechanism is not fully understood. Studies have confirmed that endolymphatic hydrops is closely related to the inner ear ion and water transport channels. This article reviews the studies on the correlation between endolymphatic hydrops and inner ear epithelial sodium channels(ENaC)and aquaporins(AQPs)and discusses the mechanism underlying endolymphatic hydrops to provide favorable references for future studies on the pathogenesis and treatment of Meniere's disease.

Key words: Epithelial sodium channel, Aquaporins, Endolymphatic metabolism, Endolymphatic hydrops

中图分类号:

R764.33

黄巧,尹时华. 内耳上皮钠通道、水通道蛋白与内淋巴代谢相关性的研究进展[J]. 山东大学耳鼻喉眼学报, 2019, 33(4): 145-148.

HUANG Qiao,YIN Shihua. Correlation between endolymphatic hydrops and inner ear epithelial sodium channels and aquaporins[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(4): 145-148.

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