山东大学耳鼻喉眼学报 ›› 2022, Vol. 36 ›› Issue (1): 20-24.doi: 10.6040/j.issn.1673-3770.0.2021.350

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新生儿动脉血血气分析与听力筛查结果相关性

盘琳琳1,方旭华1,翟丰1,桂一丁2,边洲亮3,陈洁1   

  1. 1.上海交通大学医学院附属上海儿童医学中心 耳鼻喉口腔颌面外科, 上海 200127;
    2.上海交通大学医学院附属上海儿童医学中心 儿保科, 上海 200127;
    3.上海交通大学医学院附属上海第九人民医院 肿瘤科, 上海 200125
  • 出版日期:2022-01-10 发布日期:2022-02-22
  • 通讯作者: 陈洁. E-mail:jie_chen888@163.com
  • 基金资助:
    国家自然科学基金(81900939);上海市综合医院中西医结合专项(ZHYY-ZXYJHZX-202009)

The correlation between arterial blood gas analysis and hearing screening results in neonates

PAN Linlin1, FANG Xuhua1, ZHAI Feng1, GUI Yiding2, BIAN Zhouliang3, CHEN Jie1   

  1. 1.Department of Otolaryngology and Oral & Maxillofacial Surgery, Shanghai Children's Medical Center Affiliated to Shanghai Jiaotong University, Shanghai 200127, China;
    2.Department of Children Healthcare, Shanghai Children's Medical Center Affiliated to Shanghai Jiaotong University, Shanghai 200127, China;
    3. Department of Oncology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200125, China
  • Online:2022-01-10 Published:2022-02-22

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摘要： 目的 探讨新生儿动脉血血气分析指标与听力筛查结果的关系。 方法 回顾性分析医学中心新生儿科496例患儿听力筛查结果和入院时动脉血血气分析指标。 结果 自动听觉脑干反应(AABR)、畸变产物耳声发射(DPOAE)和声导抗和总听力筛查通过率分别为61.9%(307/496)、61.3%(304/496)、90.1%(447/496)和56.7%(281/496)。三种听力筛查方法通过率差异有统计学意义(χ2=131.00,P<0.001)。AABR与DPOAE测试结果一致性极强(Kappa=0.817,P<0.001),两者与声导抗测试一致性较弱(Kappa值分别为0.262、0.256,P均<0.001)。单因素Logisitic分析显示乳酸升高(OR=0.544,P=0.001)、二氧化碳分压升高(OR=1.917,P=0.009)、pH降低(OR=1.692,P=0.021)与听力筛查不通过显著相关。多因素Logisitic分析显示,乳酸(OR=0.627,P=0.018)、氧分压(OR=1.493,P=0.047)与听力筛查结果不通过显著相关。二氧化碳分压、pH和血氧饱和度和听力筛查结果无明显相关性(P>0.05)。 结论 新生儿缺氧及其伴随的血气变化可能会影响听力筛查结果。

关键词: 听力筛查, 乳酸, 动脉血pH, 氧分压, 二氧化碳分压, 血氧饱和度

Abstract: Objective This study aimed to examine the relationship between arterial blood gas and hearing screening test in neonates. Methods The results of hearing screening test and arterial blood gas analysis of 496 newborns in the Neonatal Department of Shanghai Children's Medical Center were retrospectively analyzed. Results The pass rate of automated auditory brainstem response(AABR), distortion product otoacoustic emissions(DPOAE)and acoustic immittance is 61.9%(307/496), 61.3%(304/496), 90.1%(447/496)and 56.7%(281/496)respectively. There were significant differences in the pass rates of the three hearing screening methods(χ2=131.00, P<0.001). The pass rate of AABR was in extremely strong consistency with that of DPOAE(Kappa=0.817, P<0.001), while the pass rate of both AABR and DPOAE were in very weak consistency with that of acoustic immittance(Kappa=0.262 and 0.256, respectively. all P<0.001). Univariate Logistic regression analysis showed that the failure of hearing screening was correlated with increased lactic acid(OR=0.544, P=0.001), increased partial pressure of carbon dioxide(OR=1.917, P=0.009)and decreased pH value(OR=1.692, P=0.021). Multivariate Logistic regression analysis showed that failed hearing screening results were correlated with increased lactic acid(OR=0.627, P=0.018)and decreased partial oxygen pressure(OR=1.493, P=0.047). No significant correlations were found between hearing screening and the results of partial pressure of carbon dioxide, pH and blood oxygen saturation(P>0.05). Conclusion Neonatal hypoxia and the accompanying change of blood gas might have an impact on hearing screening results.

Key words: Hearing screening, Lactic acid, Arterial blood pH, Oxygen partial pressure, Carbon dioxide partial pressure, Oxygen saturation

中图分类号: 

  • R764.5
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