山东大学耳鼻喉眼学报 ›› 2022, Vol. 36 ›› Issue (4): 40-48.doi: 10.6040/j.issn.1673-3770.0.2021.349
李丹1,陈腾宇1,黄演芬3,周敏2,周熠星1,阮岩2,闫亚杰2
LI Dan1, CHEN Tengyu1, HUANG Yanfen3, ZHOU Min2, ZHOU Yixing1, RUAN Yan2, YAN Yajie2
摘要: 目的 对国内“嗅觉障碍”研究进行可视化分析及合理推测,尝试为学者提供该领域的研究现状及预测未来热点方向。 方法 以“嗅觉障碍”为主题词,检索建库至2020年10月20日中国知网(CNKI)的学术论文并按纳入标准进行筛选,使用Citespace软件对该研究领域所筛选文献的作者、期刊/单位及主题词进行绘制图谱及可视化分析。 结果 整体来讲,“嗅觉障碍”研究的文献发表量呈快速上升趋势。出现频次排名靠前的作者为魏永祥、倪道凤、刘钢、杭伟、姚淋尹、韩德民及刘剑锋,“嗅觉障碍”研究发文排名第1~3例的期刊为:《临床耳鼻咽喉头颈外科杂志》《国际耳鼻咽喉头颈外科杂志》《中华耳鼻咽喉头颈外科杂志》,合作高产单位并具有一定影响力的机构为首都医科大学附属北京安贞医院、中国医学科学院北京协和医院等。主题词聚类分析呈现出7个聚类:慢性鼻-鼻窦炎、帕金森病、kallmann、鼻炎、新型冠状病毒肺炎、超微结构和针刺。 结论 在“嗅觉障碍”领域,早期韩德民、李志春等国内作者对“嗅觉障碍”的研究较深长,而近年来魏永祥、倪道凤等国内作者对“嗅觉障碍”的检测方法、病因、发病机制等进行基础研究及归纳分类,是近年来嗅觉障碍研究的主力,但核心作者中心中介值均小于0.1,这表明关系较稀疏,需加强联络与合作,以期形成学术共同体提高整体影响力。根据聚类分析可知,国内作者目前对“嗅觉障碍”研究热点主要集中在嗅觉障碍与慢性鼻-鼻窦炎伴或不伴鼻息肉、帕金森病、新型冠状病毒肺炎(COVID-19)等原发病之间的联系,探索其生理病理及发病机制;不同类型嗅觉障碍的临床特点及流行病学调查;探索鼻内镜手术、针刺等不同治疗方法对嗅觉障碍的疗效。且从发文突现图可见,以上七大聚类研究范围可能将持续成为该领域重要的热点。其中慢性鼻-鼻窦炎伴或不伴鼻息肉方向是从古至今延续的热点,而COVID-19将成为未来5~10年的热点。另外,不排除COVID-19引起的嗅觉障碍与鼻腔炎症相关,且两者的相关性将会成为嗅觉障碍将来的研究热点与难点。
中图分类号:
[1] 中华耳鼻咽喉头颈外科杂志编辑委员会鼻科组, 中华医学会耳鼻咽喉头颈外科学分会鼻科学组. 嗅觉障碍诊断和治疗专家共识(2017年)[J]. 中华耳鼻咽喉头颈外科杂志, 2018(7): 484-494. doi:10.3760/cma.j.issn.1673-0860.2018.07.002. Subspecialty Group of Rhinology;Editorial Board of Chinese Journal of Otorhinolaryngology Head. Expert consensus on diagnosis and treatment of olfactory dysfunction(2017)[J]. Chinese Journal of Otorhinolaryngology Head and Neck Surgery, 2018(7): 484-494. doi:10.3760/cma.j.issn.1673-0860.2018.07.002. [2] Hoffman HJ, Rawal S, Li CM, et al. New chemosensory component in the US National Health and Nutrition Examination Survey(NHANES): first-year results for measured olfactory dysfunction[J]. Rev Endocr Metab Disord, 2016, 17(2): 221-240. doi:10.1007/s11154-016-9364-1. [3] 秦雅楠, 王琳, 丰暖, 等. 1705例嗅觉功能障碍临床与疗效分析[J]. 中国中西医结合耳鼻咽喉科杂志, 2020, 28(6): 411-417, 426. doi:10.16542/j.cnki.issn.1007-4856.2020.06.004. QIN Yanan, WANG Lin, FENG Nuan, et al. Clinical and therapeutic analysis of 1705 patients with olfactory dysfunction[J]. Chinese Journal of Otorhinolaryngology in Integrative Medicine, 2020, 28(6): 411-417, 426. doi:10.16542/j.cnki.issn.1007-4856.2020.06.004. [4] Whitcroft KL, Hummel T. Olfactory dysfunction in COVID-19: diagnosis and management[J]. JAMA, 2020, 323(24): 2512-2514. doi:10.1001/jama.2020.8391. [5] Sedaghat AR, Gengler I, Speth MM. Olfactory dysfunction: a highly prevalent symptom of COVID-19 with public health significance[J]. Otolaryngol Head Neck Surg, 2020, 163(1): 12-15. doi:10.1177/0194599820926464. [6] Hoffman HJ, Ishii EK, Macturk RH. Age-related changes in the prevalence of smell/taste problems among the United States adult population: results of the 1994 disability supplement to the nationalhealth interview survey(NHIS)[J]. Annals NY Acad Sci, 1998, 855: 716-722. doi:10.1111/j.1749-6632.1998.tb10650.x. [7] Croy I, Nordin S, Hummel T. Olfactory disorders and quality of life: an updated review[J]. Chem Senses, 2014, 39(3): 185-194. doi:10.1093/chemse/bjt072. [8] Chen HL, Shrestha S, Huang XM, et al. Olfaction and incident Parkinson disease in US white and black older adults[J]. Neurology, 2017, 89(14): 1441-1447. doi:10.1212/WNL.0000000000004382. [9] Pinto JM, Wroblewski KE, Kern DW, et al. Olfactory dysfunction predicts 5-year mortality in older adults[J]. PLoS One, 2014, 9(10): e107541. doi:10.1371/journal.pone.0107541. [10] Chen CM. Science mapping: a systematic review of the literature[J]. J Data Inf Sci, 2017, 2(2): 1-40. doi:10.1515/jdis-2017-0006. [11] 肖西立, 聂渝晓, 陈婕. 国内近10年干眼相关研究: 基于Citespace的可视化分析[J]. 山东大学耳鼻喉眼学报, 2021, 35(2): 86-97. doi:10.6040/j.issn.1673-3770.0.2020.271. XIAO Xili, NIE Yuxiao, CHEN Jie. Visual analysis of domestic studies on dry eye syndrome in the past ten years using Citespace[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(2): 86-97. doi:10.6040/j.issn.1673-3770.0.2020.271. [12] 陈悦. 引文空间分析原理与应用:CiteSpace实用指南[M]. 北京: 科学出版社, 2014. [13] 杨凌,魏永祥,张伟,等.嗅觉味觉功能的临床检测[J].临床耳鼻咽喉头颈外科杂志, 2012, 26(14):625-629. YANG Ling, WEI Yongxiang, ZHANG Wei, et al.Clinical examination of olfactory and gustatory function[J]. Journal of Clinical Otorhinolaryngology Head and Neck Surgery, 2012, 26(14):625-629. [14] 张丽川, 孙敬武, 胡春华, 等. 慢性鼻窦炎伴鼻息肉患者嗅觉障碍的影响因素分析[J]. 中华耳鼻咽喉头颈外科杂志, 2020, 55(4): 350-357. doi:10.3760/cma.j.cn115330-20190614-00383. ZHANG Lichuan, SUN Jingwu, HU Chunhua, et al. Analysis of factors affecting olfactory disfunctions in patients with chronic rhinosinusitis with nasal polyps[J]. Chinese Journal of Otorhinolaryngology Head and Neck Surgery, 2020, 55(4): 350-357. doi:10.3760/cma.j.cn115330-20190614-00383. [15] 闫晓光, 高星, 孙智甫, 等. 嗅觉训练治疗嗅觉障碍的临床疗效和影响因素分析[J]. 中华耳鼻咽喉头颈外科杂志, 2018, 53(11): 815-819. doi:10.3760/cma.j.issn.1673-0860.2018.11.004. YAN Xiaoguang, GAO Xing, SUN Zhifu, et al. Efficacy and associated factors of olfactory training in the treatment of olfactory dysfunction[J]. Chinese Journal of Otorhinolaryngology Head and Neck Surgery, 2018, 53(11): 815-819. doi:10.3760/cma.j.issn.1673-0860.2018.11.004. [16] 刘一帆, 姚淋尹, 郭怡辰, 等. 外伤性嗅觉障碍患者的临床特点及随访研究[J]. 临床耳鼻咽喉头颈外科杂志, 2017, 31(22): 1726-1731. doi:10.13201/j.issn.1001-1781.2017.22.006. LIU Yifan, YAO Linyin, GUO Yichen, et al. Differences in clinical features of post-traumatic olfactory dysfunction and non-post-traumatic olfactory dysfunction: a follow-up study[J]. Journal of Clinical Otorhinolaryngology Head and Neck Surgery, 2017, 31(22): 1726-1731. doi:10.13201/j.issn.1001-1781.2017.22.006. [17] 田俊, 魏永祥, 李丽, 等. 141例病毒感染性嗅觉障碍患者的临床特征分析[J]. 临床耳鼻咽喉头颈外科杂志, 2017, 31(10): 749-752, 756. doi:10.13201/j.issn.1001-1781.2017.10.003. TIAN Jun, WEI Yongxiang, LI Li, et al. Analysis of clinical characteristics of 141 patients with postviral olfactory dysfunction[J]. Journal of Clinical Otorhinolaryngology Head and Neck Surgery, 2017, 31(10): 749-752, 756. doi:10.13201/j.issn.1001-1781.2017.10.003. [18] 杨凌, 魏永祥, 张伟, 等. 嗅觉功能障碍患者鼻内三叉神经功能的评估[J]. 中国耳鼻咽喉头颈外科, 2012, 19(9): 497-501. doi:10.16066/j.1672-7002.2012.09.013. YANG Ling, WEI Yongxiang, ZHANG Wei, et al. Evaluations of intranasal trigeminal function in patients with olfactory dysfunction[J]. Chinese Archives of Otolaryngology-Head and Neck Surgery, 2012, 19(9): 497-501. doi:10.16066/j.1672-7002.2012.09.013. [19] 张丽川, 胡春华, 韩星雨, 等. 鼻息肉患者组织嗜酸粒细胞计数与改良鼻窦CT嗅区评分及嗅觉功能的关系[J]. 临床耳鼻咽喉头颈外科杂志, 2019, 33(12): 1142-1147. doi:10.13201/j.issn.1001-1781.2019.12.007. ZHANG Lichuan, HU Chunhua, HAN Xingyu, et al. Correlation of tissue eosinophil count and modified CT olfactory cleft score and olfactory function in patients with nasal polyps[J]. Journal of Clinical Otorhinolaryngology Head and Neck Surgery, 2019, 33(12): 1142-1147. doi:10.13201/j.issn.1001-1781.2019.12.007. [20] 张丽川, 孙敬武, 李希平, 等. 内镜鼻窦手术对慢性鼻-鼻窦炎伴鼻息肉患者嗅觉功能转归的影响[J]. 临床耳鼻咽喉头颈外科杂志, 2019, 33(8): 713-717. doi:10.13201/j.issn.1001-1781.2019.08.008. ZHANG Lichuan, SUN Jingwu, LI Xiping, et al. Effect of endoscopic sinus surgery on olfactory function in patients with chronic rhinosinusitis with nasal polyps[J]. Journal of Clinical Otorhinolaryngology Head and Neck Surgery, 2019, 33(8): 713-717. doi:10.13201/j.issn.1001-1781.2019.08.008. [21] 倪道凤. 嗅觉障碍和嗅觉功能检查[J]. 临床耳鼻咽喉科杂志, 2003, 17(9): 571-575. doi:10.3969/j.issn.1001-1781.2003.09.044. [22] 刘剑锋, 韩红蕾, 王蓓, 等. 布地奈德雾化混悬剂联合鼠神经生长因子治疗感冒后嗅觉障碍[J]. 临床耳鼻咽喉头颈外科杂志, 2015, 29(20): 1787-1789. doi:10.13201/j.issn.1001-1781.2015.20.007. LIU Jianfeng, HAN Honglei, WANG Bei, et al. Budesonide nebulizing suspension combined with nerve growth factor for the treatment of olfactory dysfunction following viral infection of the upper respiratory tract[J]. Journal of Clinical Otorhinolaryngology Head and Neck Surgery, 2015, 29(20): 1787-1789. doi:10.13201/j.issn.1001-1781.2015.20.007. [23] 刘剑锋, 韩红蕾, 庞春红, 等. 糖皮质激素雾化吸入和嗅觉训练治疗感冒后嗅觉障碍[J]. 中国耳鼻咽喉头颈外科, 2015, 22(12): 623-626. doi:10.16066/j.1672-7002.2015.12.007. LIU Jianfeng, HAN Honglei, PANGChunhong, et al. Nebulized glucocorticoid combined with olfactory training in the treatment of postviral olfactory dysfunction[J]. Chinese Archives of Otolaryngology-Head and Neck Surgery, 2015, 22(12): 623-626. doi:10.16066/j.1672-7002.2015.12.007. [24] 刘剑锋, 韩红蕾, 关静, 等. 糖皮质激素治疗嗅觉障碍的临床研究现状[J]. 中华耳鼻咽喉头颈外科杂志, 2014, 49(12): 1046-1048. doi:10.3760/cma.j.issn.1673-0860.2014.12.021. [25] 姚淋尹,郭怡辰,占小俊,等.嗅觉障碍患者脑白质完整性的初步研究[J].中华耳鼻咽喉头颈外科杂志, 2018,53(7):495-499. doi:10.3760/cma.j.issn.1673-0860.2018.07.003. YAO Linyin, GUO Yichen, ZHAN Xiaojun, et al. The preliminary study of white matter integrity in patients with olfactory dysfunction[J]. Chinese Journal of Otorhinolaryngology Head and Neck Surgery,2018,53(7):495-499. doi:10.3760/cma.j.issn.1673-0860.2018.07.003. [26] 姚淋尹, 郭怡辰, 占小俊, 等. 采用基于体素的形态测量学方法评价嗅觉功能减退患者脑体积的改变[J]. 中华耳鼻咽喉头颈外科杂志, 2018, 53(6): 414-418. doi:10.3760/cma.j.issn.1673-0860.2018.06.004. YAO Linyin, GUO Yichen, ZHAN Xiaojun, et al. Assessment of the brain volume alterations in patients with hyposmia based on voxel-based morphometry[J]. Chinese Journal of Otorhinolaryngology Head and Neck Surgery, 2018, 53(6): 414-418. doi:10.3760/cma.j.issn.1673-0860.2018.06.004. [27] 苏百晗, 孙智甫, 陈忠维, 等. 18F-FDG用于评估外伤性嗅神经损伤对药物经鼻脑通路运输的影响[J]. 临床耳鼻咽喉头颈外科杂志, 2019, 33(12): 1148-1153. doi:10.13201/j.issn.1001-1781.2019.12.008. SU Baihan, SUN Zhifu, CHEN Zhongwei, et al. Using of 18F-FDG to evaluate the effect of traumatic olfactory nerve injury on drug delivery through the nasal-brain pathway: a PET-MRI pilot study[J]. Journal of Clinical Otorhinolaryngology Head and Neck Surgery, 2019, 33(12): 1148-1153. doi:10.13201/j.issn.1001-1781.2019.12.008. [28] 杨润琴, 陈福权. 慢性鼻窦炎与嗅觉功能障碍[J]. 中国中西医结合耳鼻咽喉科杂志, 2020, 28(3): 224-225, 229. doi:10.16542/j.cnki.issn.1007-4856.2020.03.015. [29] Hoffman HJ, Ishii EK, Macturk RH. Age-related changes in the prevalence of smell/taste problems among the United States adult population: results of the 1994 disability supplement to the nationalhealth interview survey(NHIS)[J]. Annals NY Acad Sci, 1998, 855(1): 716-722. doi:10.1111/j.1749-6632.1998.tb10650.x. [30] Tu MQ, Hu HT, Hu RJ, et al. Clinical application and mechanism exploration on dysosmia treated with acupuncture and moxibustion[J]. Chin Acupunct Moxibustion, 2020, 40(4): 425-428. doi:10.13703/j.0255-2930.20190320-k0001. [31] 王强, 刘智斌, 王渊, 等. 针刺“嗅三针”对帕金森病小鼠嗅球病理及黑质中TH表达的影响[J]. 山东中医药大学学报, 2018, 42(5): 446-448, 465. doi:10.16294/j.cnki.1007-659x.2018.05.018. WANG Qiang, LIU Zhibin, WANG Yuan, et al. Effects of acupuncturing “Xiusanzhen” on olfactory bulb pathology and TH expression in substantia nigra of mice with Parkinson's disease[J]. Journal of Shandong University of Traditional Chinese Medicine, 2018, 42(5): 446-448, 465. doi:10.16294/j.cnki.1007-659x.2018.05.018. [32] 王文秀, 王凤笑, 马凤君, 等. 针药结合治疗嗅觉障碍验案[J]. 中医外治杂志, 2020, 29(2): 80. doi:10.3969/j.issn.1006-978X.2020.02.041. [33] Rey NL, Petit GH, Bousset L, et al. Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice[J]. Acta Neuropathol, 2013, 126(4): 555-573. doi:10.1007/s00401-013-1160-3. [34] Leonhardt B, Tahmasebi R, Jagsch R, et al. Awareness of olfactory dysfunction in Parkinson's disease[J]. Neuropsychology, 2019, 33(5): 633-641. doi:10.1037/neu0000544. [35] Pierzchlewska MM, Robaczyk MG, Vogel I. Induction of puberty with human chorionic gonadotropin(hCG)followed by reversal of hypogonadotropic hypogonadism in Kallmann syndrome[J]. Endokrynol Pol, 2017, 68(6): 692-696. doi:10.5603/EP.a2017.0059. [36] Gautier JF, Ravussin Y. A new symptom of COVID-19: loss of taste and smell[J]. Obesity(Silver Spring), 2020, 28(5): 848. doi:10.1002/oby.22809. [37] Lechien JR, Chiesa-Estomba CM, de Siati DR, et al. Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease(COVID-19): a multicenter European study[J]. Eur Arch Otorhinolaryngol, 2020, 277(8): 2251-2261. doi:10.1007/s00405-020-05965-1. [38] Moein ST, Hashemian SM, Mansourafshar B, et al. Smell dysfunction: a biomarker for COVID-19[J]. Int Forum Allergy Rhinol, 2020, 10(8): 944-950. doi:10.1002/alr.22587. [39] Saniasiaya J, Islam MA, Abdullah B. Prevalence of olfactory dysfunction in coronavirus disease 2019(COVID-19): a meta-analysis of 27, 492 patients[J]. Laryngoscope, 2021, 131(4): 865-878. doi:10.1002/lary.29286. |
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