布地奈德联合盐酸氨溴索鼓室内注射治疗成人分泌性中耳炎的疗效研究

doi:10.6040/j.issn.1673-3770.0.2022.312

摘要/Abstract

摘要： 目的探讨分泌性中耳炎患者采用布地奈德联合盐酸氨溴索鼓室内注射方案进行治疗的临床效果。方法选择门诊接受治疗的60例分泌性中耳炎患者,采用随机数字表法分成观察组、对照组和试验组,各20例。观察组采用常规鼓室抽液方法,对照组采用盐酸氨溴索鼓室内注射方案进行治疗,试验组采用布地奈德联合盐酸氨溴索鼓室内注射方案进行治疗。对比三组病情控制总有效率、治疗前后炎症反应相关指标水平、耳部功能相关指标、症状消失、耳内状态检查结果复常时间及不良反应。结果试验组患者病情控制总有效率均高于观察组与对照组(P<0.001);试验组治疗前后炎症反应相关指标水平、耳部功能相关指标的改善幅度均大于观察组与对照组(P<0.001);试验组症状消失、耳内状态检查结果复常时间均短于观察组与对照组(P<0.001);三组不良反应比较差异无统计学意义(P=0.804)。结论分泌性中耳炎患者采用布地奈德联合氨溴索鼓室内注射方案进行治疗,能够有效控制炎症反应、改善炎性指标和耳部功能、缩短治疗时间、提高治疗总有效率。

关键词: 分泌性中耳炎, 布地奈德, 盐酸氨溴索, 鼓室内注射

Abstract: Objective The aim of this study was to investigate the clinical efficacy of intratympanic injection comprising budesonide combined with ambroxol hydrochloride in treating secretory otitis media in adults. Methods Sixty patients with secretory otitis media who were selected and divided randomly into three groups; the observation, control, and experimental groups, each with 20 patients. The observation group received tympanocentesis and drainage; the control group was administered intratympanic ambroxol hydrochloride, and the experimental group was administered intratympanic budesonide combined with ambroxol hydrochloride. The three groups were compared prior and after the treatment with regard to the total effective rate of disease control, level of inflammatory response-related indexes, ear function-related indexes, time taken for symptom disappearance, time taken to recover based on the examination results of the internal ear, and incurrence of any adverse reactions. Results The total effective rate of disease control in patients in the experimental group was higher than those in the observation and control groups(all P<0.001). The level of inflammatory response- and ear function-related indexes in the experimental group before and after treatment improved more significantly than those in the observation and control groups(all P<0.001); the time taken for symptom disappearance and normal recovery in the experimental group was shorter than those in the observation and control groups(all P<0.001); no significantly different adverse reactions were observed between the three groups(P=0.804). Conclusions Treatment of patients with secretory otitis media by intratympanic injection of budesonide combined with ambroxol hydrochloride can effectively control the inflammatory response, improve the inflammatory indexes and ear function, shorten the treatment time, and improve the total treatment efficiency.

Key words: Secretory otitis media, Budesonide, Ambroxol hydrochloride, Intratympanic injection

中图分类号:

R764.21

孙艳,姚浩,顾黎安. 布地奈德联合盐酸氨溴索鼓室内注射治疗成人分泌性中耳炎的疗效研究[J]. 山东大学耳鼻喉眼学报, 2022, 36(6): 77-82.

SUN Yan, YAO Hao, GU Li'an. Clinical efficacy of intratympanic administration of budesonide combined with ambroxol hydrochloride in the treatment of secretory otitis media in adults[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(6): 77-82.

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