Madelung病伴阴囊脂肪堆积1例并文献复习

doi:10.6040/j.issn.1673-3770.0.2022.140

摘要/Abstract

摘要： 目的探讨Madelung病的临床特点及诊断和治疗方法。方法回顾性分析1例经外科手术治疗的Madelung病伴阴囊脂肪堆积患者的临床资料,并结合相关文献进行分析。结果采取外科手术切除患者脂肪组织,术后随访半年,随访期间无复发。结论 Madelung病主要发生在有长期饮酒史的中年男性,其特点是存在进展性、过度和多发性脂肪瘤,呈对称分布,查体时要注意患者其他部位的异常脂肪团块蓄积,并及时联系相应科室干预;为了避免复发,外科手术切除是目前首选的治疗方法,手术的主要目的是改变患者外观形象并改善功能障碍,伴阴囊脂肪堆积的患者应避免出现隐匿阴茎综合征、性功能障碍或睾丸萎缩等并发症。

关键词: 马德龙病, 脂肪瘤样病, 头颈部疾病, 外科手术, 阴囊

Abstract: Objective To investigate the clinical features and the selection of diagnosis and treatment methods for Madelung's disease. Methods Clinical data of a patient with Madelung's disease with scrotal fat accumulation treated surgically in the author's hospital and the related literature were analyzed. Results The patient underwent surgical resection of the adipose tissue and was followed up for half a year. There was no recurrence during the follow-up period. Conclusion Madelung's disease mainly occurs in middle-aged men with a long-term drinking history. It is characterized by the presence of multiple, progressive, excessive lipomas with a symmetrical distribution. During physical examination, the accumulation of abnormal fat mass in other parts may be observed. Timely referral to the corresponding department for intervention is important. To avoid recurrence, surgical resection is currently the preferred treatment. Surgery also aims to improve the patient's appearance and any functional impairment. Complications such as occult penile syndrome, sexual dysfunction, or testicular atrophy should be avoided in patients with scrotal fat accumulation.

Key words: Madelung's disease, Lipomatoid disease, Head and neck disease, Surgery, Scrotum

中图分类号:

R653

彭薪燃,李永团. Madelung病伴阴囊脂肪堆积1例并文献复习[J]. 山东大学耳鼻喉眼学报, 2023, 37(3): 67-71.

PENG Xinran, LI Yongtuan. A case of Madelung's disease with scrotal fat accumulation[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(3): 67-71.

参考文献

[1] Brodie BC. Lectures illustrative of various subjects in pathology and surgery[J]. Med Chir Rev, 1846, 4(7): 1-22.
[2] Ruzicka T, Vieluf D, Landthaler M, et al. Benign symmetric lipomatosis launois-bensaude[J]. J Am Acad Dermatol, 1987, 17(4): 663-674. doi:10.1016/s0190-9622(87)70253-9
[3] Klopstock T, Naumann M, Schalke B, et al. Multiple symmetric lipomatosis: abnormalities in complex IV and multiple deletions in mitochondrial DNA[J]. Neurology, 1994, 44(5): 862-866. doi:10.1212/wnl.44.5.862
[4] Becker-Wegerich P, Steuber M, Olbrisch R, et al. Defects of mitochondrial respiratory chain in multiple symmetric lipomatosis[J]. Arch Dermatol Res, 1998, 290(12): 652-655. doi:10.1007/s004030050368
[5] Faga A, Valdatta LA, Thione A, et al. Ultrasound assisted liposuction for the palliative treatment of Madelung's disease: a case report[J]. Aesthetic Plast Surg, 2001, 25(3): 181-183. doi:10.1007/s002660010118
[6] Szewc M, Sitarz R, Moroz N, et al. Madelung's disease-progressive, excessive, and symmetrical deposition of adipose tissue in the subcutaneous layer: case report and literature review[J]. Diabetes Metab Syndr Obes, 2018, 11: 819-825. doi:10.2147/DMSO.S181154
[7] Mayo Yáñez M, González Poggioli N, Álvarez-Buylla Blanco M, et al. Benign symmetric lipomatosis with lingual involvement: case report and literature review[J]. J Stomatol Oral Maxillofac Surg, 2018, 119(2): 148-150. doi:10.1016/j.jormas.2017.11.006
[8] 王宪玲, 孙永馨, 杨延辉, 等. 多发性对称性脂肪瘤病(Madelung's病)合并中枢神经系统损害1例报告并文献复习[J]. 北京医学, 2014, 36(5): 350-353. doi:10.15932/j.0253-9713.2014.05.013 WANG Xianling, SUN Yongxin, YANG Yanhui, et al. Central nervous system damage in multiple symmetric lipomatosis(Madelung's disease)[J]. Beijing Medical Journal, 2014, 36(5): 350-353. doi:10.15932/j.0253-9713.2014.05.013
[9] Ujpál M, Németh ZS, Reichwein A, et al. Long-term results following surgical treatment of benign symmetric lipomatosis(BSL)[J]. Int J Oral Maxillofac Surg, 2001, 30(6): 479-483. doi:10.1054/ijom.2001.0162
[10] 雷蕾, 赵宇, 熊升华. Ⅰ型马德龙病临床分析[J]. 中国耳鼻咽喉头颈外科, 2015, 22(2): 85-87. doi:10.16066/j.1672-7002.2015.02.010 LEI Lei, ZHAO Yu, XIONG Shenghua. Analysis of I type madelung's disease[J]. Chinese Archives of Otolaryngology-Head and Neck Surgery, 2015, 22(2): 85-87. doi:10.16066/j.1672-7002.2015.02.010
[11] Ostrowski KR, Rubin AD. Benign symmetric lipomatosis involving the supraglottic larynx: a rare cause of dysphonia[J]. Otolaryngol Head Neck Surg, 2011, 145(2): 360-361. doi:10.1177/0194599811402162
[12] Lee LC, Weng TH, Huang KH, et al. Application of lateral tarsoconjunctival flap to correct ocular complications of Madelung's disease: a case report and literature review[J]. Medicine, 2018, 97(42): e12864. doi:10.1097/MD.0000000000012864
[13] Gozzo C, Galioto F, Palmucci S, et al. A non-alcohol-related case of Madelung's disease: challenging patient with progressive jugular vein distension[J]. Radiol Case Rep, 2021, 16(5): 1183-1187. doi:10.1016/j.radcr.2021.02.050
[14] Yan YJ, Zhou SQ, Li CQ, et al. Diagnostic and surgical challenges of progressive neck and upper back painless masses in Madelung's disease: a case report and review of literature[J]. World J Clin Cases, 2022, 10(1): 361-370. doi:10.12998/wjcc.v10.i1.361
[15] da Costa JN, Gomes T, Matias J. Madelung disease affecting scrotal region[J]. Ann Plast Surg, 2017, 78(1): 73-77. doi:10.1097/SAP.0000000000000714
[16] Andou E, Komoto M, Hasegawa T, et al. Surgical excision of madelung disease using bilateral cervical lymphnode dissection technique-its effect and the influence of previous injection lipolysis[J]. Plast Reconstr Surg Glob Open, 2015, 3(4): e375. doi:10.1097/GOX.0000000000000337
[17] Tsilivigkos C, Mastronikolis S, Lygeros S, et al. Multiple symmetric lipomatosis(Madelung's disease)with symptoms and signs of hypertension, lipodystrophy, and dyspnea: a case report and literature review[J]. Clin Case Rep, 2021, 9(6): e04288. doi:10.1002/ccr3.4288

相关文章 15

[1]	陈世琴,卫平存,胡云龙,胡金旺. 糖皮质激素三种不同鼻用法对鼻内镜术后黏膜转归的影响[J]. 山东大学耳鼻喉眼学报, 2022, 36(3): 195-201.
[2]	赵笑冰,张大为,陈仁杰. 中耳间变性大T细胞淋巴瘤1例并文献复习[J]. 山东大学耳鼻喉眼学报, 2022, 36(2): 7-14.
[3]	赵雅铭,石崧. 以急性会厌炎为首诊的3例颈部坏死性筋膜炎病例报告并文献复习[J]. 山东大学耳鼻喉眼学报, 2021, 35(4): 12-16.
[4]	石玉琦,佘翠平,张庆丰,刘得龙,焦梦思. 早期声门型喉癌低温等离子射频术后喉部感染诊治经验与教训[J]. 山东大学耳鼻喉眼学报, 2021, 35(4): 129-134.
[5]	朱华明,关建,茆松,张维天,易红良. 低温等离子射频消融辅助咽旁间隙良性肿瘤切除的应用分析[J]. 山东大学耳鼻喉眼学报, 2021, 35(2): 28-33.
[6]	郭芳,张德军,傅则名,郭颖媛,万怡宁,管国芳. 外耳道胆脂瘤并发化脓性腮腺炎1例并文献复习[J]. 山东大学耳鼻喉眼学报, 2020, 34(6): 12-15.
[7]	郑美君,杨慧,胡娟娟. 喉显微外科治疗声门型喉蹼的研究进展[J]. 山东大学耳鼻喉眼学报, 2019, 33(5): 144-147.
[8]	王海英. 鼻内镜下二线减张鼻中隔矫正术43例临床分析[J]. 山东大学耳鼻喉眼学报, 2019, 33(5): 166-168.
[9]	陈国辉,和守睆,孙青,高天乐,白广平. 鼻内镜术中不同中鼻甲处理方式治疗慢性鼻-鼻窦炎伴鼻息肉效果比较[J]. 山东大学耳鼻喉眼学报, 2019, 33(5): 82-86.
[10]	李强,刘志元,周涵. 鼻内镜下蝶腭动脉阻断术治疗老年难治性鼻出血[J]. 山东大学耳鼻喉眼学报, 2019, 33(5): 92-95.
[11]	李晓明. 喉癌治疗中喉功能保留的历史、现状和未来[J]. 山东大学耳鼻喉眼学报, 2019, 33(4): 1-5.
[12]	孙笑晗,李娜. 喉保留策略在喉癌治疗中的应用—美国临床肿瘤学会临床实践指南更新(2017)介绍[J]. 山东大学耳鼻喉眼学报, 2019, 33(4): 40-42.
[13]	丁洁,孙彦. 142例喉癌术后患者整体睡眠质量状况调查分析[J]. 山东大学耳鼻喉眼学报, 2019, 33(4): 76-81.
[14]	汤苏成,王跃建,陈伟雄. 颈源性纵隔脓肿手术切开概率增加的危险因素分析[J]. 山东大学耳鼻喉眼学报, 2019, 33(4): 87-91.
[15]	赵青,周涵,殷敏,冯剑,张佳程,刘雅琴,沈宇杰,林子萍,董伟达. 鼻咽纤维血管瘤术前超选择性血管栓塞的应用价值[J]. 山东大学耳鼻喉眼学报, 2019, 33(3): 100-105.

多维度评价

Viewed

Full text

Abstract

Cited

Shared

Discussed