山东大学耳鼻喉眼学报 ›› 2025, Vol. 39 ›› Issue (1): 117-122.doi: 10.6040/j.issn.1673-3770.0.2024.306
• 论著 • 上一篇
孙乐1,张云云1,刘浩2,叶京英1,吴彦桥1
SUN Le1, ZHANG Yunyun1, LIU Hao2, YE Jingying1, WU Yanqiao1
摘要: 目的 探讨腭部巨大多形性腺瘤的临床特点及个体化手术治疗方案。 方法 回顾性分析1例原发于腭部的巨大多形性腺瘤患者的临床资料,复习相关文献进行总结。 结果 腭部的多形性腺瘤一种形态复杂的上皮性肿瘤,常发生于硬腭后部与软、硬腭交界处,临床上通常表现为无症状生长缓慢的孤立性光滑肿块,有部分或完整的包膜,可引起压缩性骨质吸收。根据发病部位可引起吞咽困难、呼吸困难、咀嚼困难和鼻出血等。多形性腺瘤生长过程中有恶变的潜在危险,治疗以手术切除为主。 结论 对于原发于硬腭的巨大多形性腺瘤,治疗上应个体化评估制定手术方案。对于范围局限的肿瘤可采用传统的经硬腭入路,对于范围较大的肿瘤可采用内镜辅助经唇龈沟入路或内镜辅助经口鼻联合入路将肿物切除。
中图分类号:
[1] Bradley PJ, McGurk M. Incidence of salivary gland neoplasms in a defined UK population[J]. Br J Oral Maxillofac Surg, 2013, 51(5): 399-403. doi:10.1016/j.bjoms.2012.10.002 [2] Pires FR, Pringle GA, de Almeida OP, et al. Intra-oral minor salivary gland tumors: a clinicopathological study of 546 cases[J]. Oral Oncol, 2007, 43(5): 463-470. doi:10.1016/j.oraloncology.2006.04.008 [3] Fábio Fernandes Borém Bruzinga, Fernanda Carvalho Fulgêncio Fernandes, Fernanda Ribeiro Dias, et al. Clinical and demographic features of minor salivary gland tumors: A collaborative study of 480 cases[J]. Oral Dis, 2023, 29(3): 1028-1038. doi: 10.1111/odi.14119 [4] Wu YC, Wang YP, Cheng SJ, et al. Clinicopathological study of 74 palatal pleomorphic adenomas[J]. J Formos Med Assoc, 2016, 115(1): 25-30. doi:10.1016/j.jfma.2015.09.008 [5] 王张嵩, 谢舒乐, 张汉卿, 等. 2 456例唾液腺肿瘤临床病理分析[J]. 口腔疾病防治, 2020, 28(5): 298-302. doi:10.12016/j.issn.2096-1456.2020.05.005 WANG Zhangsong, XIE Shule, ZHANG Hanqing, et al. Clinical and pathological analysis of 2,456 cases of salivary gland tumor[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(5): 298-302. doi:10.12016/j.issn.2096-1456.2020.05.005 [6] Almeslet AS. Pleomorphic adenoma: a systematic review[J]. Int J Clin Pediatr Dent, 2020, 13(3): 284-287. doi:10.5005/jp-journals-10005-1776 [7] Kato H, Kawaguchi M, Ando T, et al. Pleomorphic adenoma of salivary glands: common and uncommon CT and MR imaging features[J]. Jpn J Radiol, 2018, 36(8): 463-471. doi:10.1007/s11604-018-0747-y [8] Zarbo RJ. Salivary gland neoplasia: a review for the practicing pathologist[J]. Mod Pathol, 2002, 15(3): 298-323. doi:10.1038/modpathol.3880525 [9] Meyer MT, Watermann C, Dreyer T, et al. 2021 update on diagnostic markers and translocation in salivary gland tumors[J]. Int J Mol Sci, 2021, 22(13): 6771. doi:10.3390/ijms22136771 [10] 袁道英, 李巧凤, 许凯, 等. 细针针吸细胞学在腮腺肿瘤性疾病诊断中的评价[J]. 中国耳鼻咽喉头颈外科, 2016, 23(12): 702-704. doi:10.16066/j.1672-7002.2016.12.006 YUAN Daoying, LI Qiaofeng, XU Kai, et al. Evaluation of diagnostic accuracy of preoperative fine needle aspiration cytology in salivary gland lesions[J]. Chinese Archives of Otolaryngology-Head and Neck Surgery, 2016, 23(12): 702-704. doi:10.16066/j.1672-7002.2016.12.006 [11] Singh M, Mokhtar EA, Akbar S, et al. Pleomorphic adenoma of the palate with an atypical malignant presentation: a case report[J]. Cureus, 2023, 15(7): e42365. doi:10.7759/cureus.42365 [12] Valstar MH, Andreasen S, Bhairosing PA, et al. Natural history of recurrent pleomorphic adenoma: implications on management[J]. Head Neck, 2020, 42(8): 2058-2066. doi:10.1002/hed.26137 [13] Singh K, Kumar Mishra A, Kour A, et al. Novel approach for management of extremely rare pleomorphic adenoma of soft palate(minor salivary glands)[J]. Indian J Otolaryngol Head Neck Surg, 2022, 74(Suppl 2): 1989-1991. doi:10.1007/s12070-020-01946-2 [14] 李匡政, 江义霞, 范晓升, 等. 不同手术方式治疗腭部涎腺肿瘤的临床观察[J]. 微创医学, 2018, 13(5): 631-632, 662. doi:10.11864/j.issn.1673.2018.05.19 LI Kuangzheng, JIANG Yixia, FAN Xiaosheng, et al. Clinical observation on different surgical methods for treating palatal salivary gland tumors[J]. Journal of Minimally Invasive Medicine, 2018, 13(5): 631-632, 662. doi:10.11864/j.issn.1673.2018.05.19 [15] 史春生,葛长艺,张庆泉,等. 腭部肿瘤61例临床分析[J]. 山东大学耳鼻喉眼学报, 2013, 27(2): 46-48. doi:10.6040/i.issn.1673-3770.0.2012.375 SHI Chunsheng, GE Changyi, ZHANG Qingquan, et al. Clinical analysis of palatine tumor in 61 cases[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2013, 27(2): 46-48. doi:10.6040/i.issn.1673-3770.0.2012.375 [16] 李立恒, 王晓明, 杨建明. 截断下颌骨切除腭部巨大多形性腺瘤临床术式分析[J]. 河北北方学院学报(自然科学版), 2011, 27(6): 81-82. doi:10.3969/j.issn.1673-1492.2011.06.023 LI Liheng, WANG Xiaoming, YANG Jianming. Clinical surgery proceduce analysis on truncating mandible to resect large palate pleomorphic adenoma[J]. Journal of Hebei North University(Natural Science Edition), 2011, 27(6): 81-82. doi:10.3969/j.issn.1673-1492.2011.06.023 [17] 谭平清, 黄文孝, 陈杰, 等. 鼻内镜辅助联合经口入路切除侵犯鼻腔鼻窦的上腭恶性肿瘤[J]. 临床耳鼻咽喉头颈外科杂志, 2022, 36(3): 194-197. doi:10.13201/j.issn.2096-7993.2022.03.008 TAN Pingqing, HUANG Wenxiao, CHEN Jie, et al. Nasal endoscopy assisting combined with transoral approach for resection of carcinoma of the palate invading nasal cavity and sinuses[J]. Journal of Clinical Otorhinolaryngology Head and Neck Surgery, 2022, 36(3): 194-197. doi:10.13201/j.issn.2096-7993.2022.03.008 [18] 饶远生,王建宏,贾弘光,等. 内镜辅助经唇龈沟入路腭部多形性腺瘤切除术[J]. 中国耳鼻咽喉头颈外科,2021,28(4):226-229.doi:10.16066j.1672-7002.2021.04.008 RAO Yuansheng, WANG Jianhong, JIA Hongguang, et al. Endoscopic-assisted resection of palatal pleomorphic adenoma via labiogingival groove approach[J]. Chinese Archives of Otolaryngology-Head and Neck Surgery, 2021, 28(4): 226-229. doi:10.16066j.1672-7002.2021.04.008 [19] 满毅,Vicha Huangphattarakul. 腭部作为口腔软组织供区的实践要点[J]. 口腔颌面外科杂志, 2020, 30(5): 265-271. MAN Yi, Vicha Huangphattarakul. Practical Points of Palate as Oral Soft Tissue Donor Site[J]. Journal of Oral and Maxillofacial Surgery, 2020, 30(5): 265-271. [20] 刘婷婷, 王学海, 蔡晓岚,等. 鼻内镜下口-鼻联合入路切除鼻底累及硬腭巨大肿瘤两例. 山东大学耳鼻喉眼学报, 2018, 32(3): 108-111. doi:10.6040/iin.1673-3770.0.2017.333 LIU Tingting, WANG Xuehai, CAI Xiaolan, et al. Excision of giant tumor in nasal floor involving palatine via oral-nasal combined approach under a nasal endoscope assisted: a report of 2 cases[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2018, 32(3): 108-111. doi:10.6040/iin.1673-3770.0.2017.333 [21] Ghadirimoghadam N, Shooshtari Z, Sargolzaie N, et al. Surgical treatment of a huge pleomorphic adenoma in the hard palate of a young female adult: a case report[J]. World J Plast Surg, 2022, 11(3): 89-94. doi:10.52547/wjps.11.3.89 |
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