关键词: 鼻息肉; 水通道蛋白8; 糖皮质激素

Abstract:

Objective    To observe the effects of budesonide (BUD) spray intra-nasally applied on expression of aquaporin 8 (AQP8) in tissues of the nasal polyps and to explore the effect of AQP8 in the pathogenesis of nasal polyps and the pharmacological mechanisms of Budesonide responsible for the treatment of nasal polyps.  Methods    Forty cases of nasal polyps were randomly divided into two groups , with 20 in the treatment group ( TG) and 20 in the control group (CG) . The TG group received BUD int ranasal spraying for 2 weeks before the operation for the nasal polyps and the CG group received no medicine. Then , immunohistochmistry was used to determine the expression of AQP8 in the tissue samples of the polyps post-operatively. Results    The positive cellular number of AQP8 in the vascular endothelia and glandular epithelia was significantly fewer in the polyp samples of TG than that of CG group( P<0.01) . However, increased number of positive AQP8 epithelia of the nasal polyps was observed in the tissue samples of TG, while there was no significant difference in comparison with CG (P>0.05) . Conclusions    BUD used locally in nasal cavity can decrease the edema degree and reduce the volume of the nasal polyps, and which may be associated with its regulatory effect on expression of AQP8 in tissues of the nasal polyps.

Key words:  Nasal polyps; Aquaporin 8; Corticosteroids