J Otolaryngol Ophthalmol Shandong Univ ›› 2013, Vol. 27 ›› Issue (3): 10-12.doi: 10.6040/j.issn.1673-3770.0.2013.082

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Clinical observation of continuous positive airway pressure  combined with captopril and nifedipine in the treatment of patients with severe OSAHS accompanied with hypertension

YANG Rong, ZONG Tao, SUN Ya-nan, LU Jin-fa   

  1. Department of Otolaryngology, Qingdao Chenyang People’s Hospital, Qingdao 266109, Shandong, China
  • Received:2013-03-15 Published:2013-06-16

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Abstract:

Objective To investigate the effect of continuous positive airway pressure (CPAP) combined with captopril and nifedipine on severe obstructive sleep apnea hypopnea syndrome (OSAHS) patients with hypertension. Methods Sixty-six patients with severe OSAHS accompanied with hypertension were randomly divided into control group and CPAP group. In control group, the patients underwent captopril and nifedipine treatment for 8 weeks, while in CPAP group, extra CPAP treatment was applied concurrently for 4 weeks. Systolic and diastolic blood pressures were measured at 22:00, 2:00, 6:00 respectively. Effective rate and blood pressure changes before and after the treatment between the two groups were compared. Results The effective rates in both groups showed no significant differences at 22:00 (Ctrl 78.8%; CPAP 75.6%) and 2:00 (Ctrl 63.6%; CPAP 60.6%) (P>0.1, P>0.1). However, effective rate in CPAP group was significantly higher (75.6%) than that of control group (51.5%) at 6:00 (0.025

Key words: Hypertension, Nifedipine, Obstructive sleep apnea hypopnea syndrome, Captopril, Clinical observation, Continuous positive airway pressure

CLC Number: 

  • R766.7
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