J Otolaryngol Ophthalmol Shandong Univ ›› 2013, Vol. 27 ›› Issue (3): 10-12.doi: 10.6040/j.issn.1673-3770.0.2013.082

• Articles • Previous Articles     Next Articles

Clinical observation of continuous positive airway pressure  combined with captopril and nifedipine in the treatment of patients with severe OSAHS accompanied with hypertension

YANG Rong, ZONG Tao, SUN Ya-nan, LU Jin-fa   

  1. Department of Otolaryngology, Qingdao Chenyang People’s Hospital, Qingdao 266109, Shandong, China
  • Received:2013-03-15 Published:2013-06-16

PDF (PC)

502

Abstract:

Objective To investigate the effect of continuous positive airway pressure (CPAP) combined with captopril and nifedipine on severe obstructive sleep apnea hypopnea syndrome (OSAHS) patients with hypertension. Methods Sixty-six patients with severe OSAHS accompanied with hypertension were randomly divided into control group and CPAP group. In control group, the patients underwent captopril and nifedipine treatment for 8 weeks, while in CPAP group, extra CPAP treatment was applied concurrently for 4 weeks. Systolic and diastolic blood pressures were measured at 22:00, 2:00, 6:00 respectively. Effective rate and blood pressure changes before and after the treatment between the two groups were compared. Results The effective rates in both groups showed no significant differences at 22:00 (Ctrl 78.8%; CPAP 75.6%) and 2:00 (Ctrl 63.6%; CPAP 60.6%) (P>0.1, P>0.1). However, effective rate in CPAP group was significantly higher (75.6%) than that of control group (51.5%) at 6:00 (0.025

Key words: Hypertension, Nifedipine, Obstructive sleep apnea hypopnea syndrome, Captopril, Clinical observation, Continuous positive airway pressure

CLC Number: 

  • R766.7
[1] SU Jie, AI Xin, MA Chunmei, YANG Fuyu, HUANG Shuai. Relationship between acute intraocular hypertension and lateral geniculate neuron autophagy and apoptosis in rats [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(4): 68-71.
[2] LI Ling, WANG Chunling, ZHANG Li, LI Yanzhong.. Predictors of difficult airway in patients with obstructive sleep apnea-hypopnea syndrome during general anesthesia. [J]. J Otolaryngol Ophthalmol Shandong Univ, 2017, 31(6): 62-67.
[3] LIU Wenjun, YU Xueying, LÜ Dan, CHEN Zhenggang, ZHANG Yanqing, MEI Xubin, YANG Ke. Correlation between obstructive sleep apnea hypopnea syndrome and upper airway measurements of different genders. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(4): 54-59.
[4] CHEN Xuan, HAN Li, FAN Chuanfeng, LI Yingmei, LIU Jian, SHU Xiangwen, WANG Yu. Expression of endothelin-1 in plasma of patients with hypertensive retinopathy in essential hypertension. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(6): 78-80.
[5] YU Qingqing, TANG Jun, WANG Yuejian. A systemic review system to evaluate the effects of different tonsil and adenoid surgical methods on children with obstructive sleep apnea-hypopnea syndrome. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(5): 42-48.
[6] LI Yanzhong. Obesity and obstructive sleep apnea. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(5): 1-4.
[7] LIANG Xiaohong, LI Yan, LI Chong. Obstructive sleep apnea hypopnea syndrome and Fibroblast growth factor 21. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(5): 81-84.
[8] XU Meijie, SU Mei, XUE Rong, ZHANG Xilong. Correlation between neutrophil / lymphocyte ratio and severity of obstructive sleep apnea syndrome. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(5): 33-37.
[9] WANG Yan. Progress in the classification and treatment of sleep respiratory diseases in children. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(5): 5-8.
[10] SHANG Wei. Interpretation of “The Third Edition of the International Classification of Sleep Disorders(ICSD)”. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(5): 18-20.
[11] ZHU Yue, HUANG Zhichun, YANG Ming, ZHU Xin. The study of cognitive disorderin patients with obstructive sleep apnea hypopnea syndrome. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(5): 68-74.
[12] WANG Honggeng, CHEN Dongsheng, LIN Qun, HUANG Fang, HONG Yuming, HUANG Jianqiang. Effects of total intravenous anesthesia on the bleed volume during endoscopic sinus surgery. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2015, 29(4): 62-64.
[13] LI Jun-zheng, GAO Xiang, WU Gai-zhen, CHEN Sha, WANG Jie, TIAN Wen-dong, LI Xiang-ping. Application of harmonic scalpel in children with obstructive sleep apnea and hyponea syndrome [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2015, 29(1): 1-4.
[14] SU Yue, WANG Zhong-liang, ZENG Zhen. Three different operative methods in H-UPPP [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2015, 29(1): 5-7.
[15] WANG Yu-zhi, L Ling-yan, QU Zhe, WANG Xing-jie, ZHOU Xuan-yan. Changes of blood pressure in severe OSAHS patients with hypertension before and after Uvulopalatopharyngoplasty [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2014, 28(5): 7-9.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd