JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2016, Vol. 30 ›› Issue (5): 33-37.doi: 10.6040/j.issn.1673-3770.0.2016.347

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Correlation between neutrophil / lymphocyte ratio and severity of obstructive sleep apnea syndrome.

XU Meijie, SU Mei, XUE Rong, ZHANG Xilong   

  1. Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu, China
  • Received:2016-08-09 Online:2016-10-20 Published:2016-10-20

Abstract: Objective To investigate the relationship between the neutrophil / lymphocyte ratio(NLR)and severity of obstructive sleep apnea syndrome(OSAS). Methods A total of 158 subjects were recruited and divided into 4 groups based on their apnea hypopnea index(AHI)during sleep: control group(n=39), mild OSAS group(n=38), moderate OSAS group(n=41)and severe OSAS group(n=40). In addition, 31 patients in the severe OSAS group underwent 3-month continuous positive airway pressure(CPAP)treatment. White blood cells, neutrophils, lymphocytes and NLR were compared among groups as well as before and after CPAP treatment. Results The NLR in the severe OSAS group(3.29±1.19)was significantly higher than that in the normal control group(1.71±0.69), mild OSAS group(1.70±0.71); the NLR in the moderate OSAS group was significantly higher than that in the normal control group and mild OSAS group(all P<0.05); there was no significant difference in NLR between the normal control group and mild OSAS group as well as between the moderate OSAS group and severe OSAS group(all P>0.05). Comparison before and after CPAP treatment showed that NLR was significantly lowered after CPAP treatment(P<0.05). There was a positive correlation between AHI and NLR(r=0.758, P= 0.034), and a negative correlation between AHI and minimal oxygen saturation(r=-0.179, P=0.012). Conclusion NLR may elevate as OSAS becomes more severe and therefore it may serve as a new auxiliary parameter to evaluate the severity of inflammatory status in OSAS patients.

Key words: Neutrophils, Continuous positive airway pressure, Sleep apnea syndrome, obstructive, Lymphocytes

CLC Number: 

  • R766.7
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