JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2014, Vol. 28 ›› Issue (4): 77-80.doi: 10.6040/j.issn.1673-3770.0.2013.318

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Expression and significance of insulin-like growth factor-1 and extracellular-signal regulated kinase1/2 in human glomus jugular tumor

SHENG Hong-shen1, HE Yue1, HUANG De-liang2, HAN Dong-yi2, YANG Shi-ming2, DAI Pu2, WU Wen-ming2   

  1. 1. Department of Otolaryngology, Chengdu Military General Hospital, Chengdu 610083, Sichuan, China;
    2. Department of Otolaryngology & Head and Neck Surgery, General Hospital of PLA, Beijing 100853, China
  • Received:2013-11-10 Online:2014-08-16 Published:2014-08-16

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Abstract: Objective To investigate the expressions and significance of insulin-like growth factor-1(IGF-1) and extracellular-signal regulated kinase1/2(ERK1/2) in human glomus jugular tumor. Methods Immunohistochemistry was used to detect the expressions of IGF-1, ERK1 and ERK2 in 33 cases of human glomus jugular tumor and 9 cases of normal adrenal medulla. Results The expressions of IGF-1were found in 26 cases of glomus jugular tumor in which the expressions located mostly in the cytoplasm of chief cells while some in the nucleus. The expressions of IGF-1 were found in 5 cases of adrenal medulla which located mostly in the cytoplasm. The expressions of ERK1 and ERK2 were found in 24 and 25 cases of glomus jugular tumor with similar distribution restricted in the cytoplasm of chief cells. The expression of ERK1 and ERK2 were found in 4 and 5 cases of adrenal medulla with the pattern restricted in the cytoplasm. Overall, the expression intensities for IGF-1, ERK1and ERK2 in glomus jugular tumor cases were higher than those in the adrenal medulla cases. Furthermore, the expression of IGF-1 was significantly correlated with those of ERK1 and ERK2(r=0.553, 0.601, P<0.05). Conclusion The overexpression of IGF-1 may play an important role in tumor genesis and development via ERK1/2 signal pathway through a paracrine or autocrine manner in human glomus jugular tumors.

Key words: Glomus jugular tumor, Insulin-like growth factor-1, Extracellular-signal regulated kinase1/2

CLC Number: 

  • R730.2
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