JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2015, Vol. 29 ›› Issue (6): 31-35.doi: 10.6040/j.issn.1673-3770.0.2015.307

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Relationship between the expression of EGFL7 in nasopharyngeal carcinoma and the invasion and metastasis of tumor

ZHAO Yanlian1, LU Yongtian2, YANG Jihong1, ZHANG Juan1, MIAO Fangfang1, LI Jieping1   

  1. 1. Guangzhou Medical University, Guangzhou 511436, Guangdong, China;
    2. Department of Otolaryngology, the Second People's Hospital of Shenzhen, Shenzhen 518005, Guangdong, China
  • Received:2015-07-26 Online:2015-12-16 Published:2015-12-16

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Abstract: Objective To study the expression of epidermal growth factor-like domain 7(EGFL7) in nasopharyngeal carcinoma(NPC), and to investigate its correlation with microvessel density(MVD) and lymphatic vessel density(LVD) and its relationship with the invasion and metastasis of NPC and its possible mechanism. Methods The immunohisto chemical method was used to detect EGFL7 expression of 40 cases of nasopharyngeal carcinoma and 20 cases of nasopharyngitis; MVD and LVD were detected by antibody CD31 and D2-40 antibody for immunohistochemistry in the experimental and control groups, and to analyze the correlation of EGFL7 expression and tumor grade and MVD and LVD. Results The experimental group and the control group were of EGFL7 expression, but in the experimental group EGFL7 expression rate was higher than that of control group (P<0.05); EGFL7 expression and MVD was positively correlated in the experimental group, but LVD did not; in the experimental group, lymph node metastasis of LVD was significantly higher than those without lymph node metastasis of (P<0.05); in the experimental group, EGFL7 expression had no correlation with patient gender, age and EB virus antibody (P>0.05) but had some correlation with clinical stage and lymph node metastasis(P<0.05). Conclusion EGFL7 has no dual function on blood vessels and lymphatic vessels, it only expresses in endothelial cells and nasopharyngeal carcinoma cells. EGFL7 is closely associated with the growth and invasion and metastasis of nasopharyngeal carcinoma (NPC), it may become one of the markers reacting nasopharyngeal carcinoma metastasis and prognosis.

Key words: Nasopharyngeal carcinoma, Epidermal growth factor-like domain 7, VEGF family, Lymphatic vessel density, Micro vessel density

CLC Number: 

  • R739.63
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