JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2016, Vol. 30 ›› Issue (1): 36-39.doi: 10.6040/j.issn.1673-3770.0.2015.377

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The expression of neurokinin-1 receptors in nasal mucosa of patients with intranasal mucosal contact point headaches.

ZHAO Guomin1, PENG Hong2, WANG Jing3, YIN Jinshu1,2.   

  1. 1. Peking University Ninth School of Clinical Medicine, Beijng 100038, China;2. Department of Otorhinolaryngology-Head and Neck Surgery, Beijing Shijitan Hospital of Capital Medical University, Beijing 100038, China;3.Central Laboratory, Beijing Shijitan Hospital of Capital Medical University, Beijing 100038, China
  • Received:2015-09-02 Online:2016-02-16 Published:2016-02-16

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Abstract: Objective To investigate the expression of neurokinin-1 receptor(NK-1R)in nasal mucosa tissue from patients with intranasal mucosal contact point headaches. Methods The expression of NK-1R was detected by immunohistochemical staining method in mucosal contact points and non-contact point from 18 patients respectively. The mRNA level of NK-1R and substance P(SP)was detected by real-time quantitative reverse transcription polymerase chain reaction(RT-PCR)at NK-1R positive cells at mucosal contact point and non-contact point respectively. Results NK-1R was mainly located in acinar epithelial cells, inflammatory cells and nerve fiber of contact point nasal mucosa. The mRNA of SP and NK-1R were up-regulated in mucosal contact point compared with those in mucosal non-contact point. Conclusion NK-1R, as a mediator of pain transmission, may play an important role in the occurrence of intranasal mucosal contact point headaches.

Key words: Mucosal contact point headaches, Substance P, Neurokinin-1 receptor

CLC Number: 

  • R765.25
[1] Westergaard M L, Hansen E H, Glümer C, et al. Prescription pain medications and chronic headache in Denmark: implications for preventing medication overuse[J]. Eur J Clin Pharmacol, 2015, 71(7):851-860.
[2] Headache Classification Subcommittee of the International Headache Society. The international classification of headache disorders:2nd edition[J].Cephalalgia, 2004, 24(S1):9-160.
[3] 王佳, 尹金淑, 李健东, 等. 鼻腔黏膜接触区与头痛关系的临床观察[J]. 中华耳鼻咽喉头颈外科杂志, 2012, 47(4):317-320. WANG Jia, YIN Jinshu, LI Jiandong, et al. Clinical observation on relation between nasal mucosa contact point and headache[J]. Chin J Otorhinolaryngol Head Neck Surg, 2012, 47(4):317-320.
[4] Mu(~overn)oz M, Cove(~overn)as R. Involvement of substance P and the NK-1 receptor in human pathology[J]. Amino Acids, 2014, 46(7):1727-1750.
[5] Heid C A, Stevens J, Livak K J, et al. Real time quantitative PCR. Genome Res[J]. Probe, 1996, 6:986-994.
[6] Morgenstein K M, Krieger M K. Experiences in middle turbinectomy[J]. Laryngoscope, 1980, 90(10):1596-1603.
[7] 孔令恒, 孙娜, 朱娟霞, 等. 脊髓NMDA受体和NK1受体在大鼠心脏伤害性感受信息传递中的作用[J]. 四川大学学报(医学版), 2013, 44(5):722-726. KONG Lingheng, SUN Na, ZHU Juanxia, et al. The role of nmda and nk1 receptors in cardiac nociceptive information transmissions in the spinal cords of rats[J]. J Sichuan Univ(Med Sci Ed), 2013, 44(5):722-726.
[8] Shirasaki H, Asakura K, Narita S I. Expression of substance P(NK1)receptor mRNA in human nose[J]. Acta Otolaryngol, 1998, 118(5):717-722.
[9] Chalastras T, Nicolopoulou-Stamati P, Patsouris E, et al. Expression of substance P, vasoactive intestinal peptide and heat shock protein 70 in nasal mucosal smears of patients with allergic rhinitis: investigation using a liquid-based method[J]. J Laryngol Otol, 2008, 122(7):700-706.
[10] Blumenthal H J. Headaches and sinus disease[J]. Headache, 2001, 41(9):883-888.
[11] Li X, Clark J D. Hyperalgesia during opioid abstinence: mediation by glutamate and substance P[J]. Anesth Analg, 2002, 95(4):979-984.
[12] Khasabov S G, Simone D A. Loss of neurons in rostral ventromedial medulla that express neurokinin-1 receptors decreases the development of hyperalgesia[J]. Neuroscience, 2013, 250:151-165.
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