JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2016, Vol. 30 ›› Issue (1): 36-39.doi: 10.6040/j.issn.1673-3770.0.2015.377

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The expression of neurokinin-1 receptors in nasal mucosa of patients with intranasal mucosal contact point headaches.

ZHAO Guomin1, PENG Hong2, WANG Jing3, YIN Jinshu1,2.   

  1. 1. Peking University Ninth School of Clinical Medicine, Beijng 100038, China;2. Department of Otorhinolaryngology-Head and Neck Surgery, Beijing Shijitan Hospital of Capital Medical University, Beijing 100038, China;3.Central Laboratory, Beijing Shijitan Hospital of Capital Medical University, Beijing 100038, China
  • Received:2015-09-02 Online:2016-02-16 Published:2016-02-16

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Abstract: Objective To investigate the expression of neurokinin-1 receptor(NK-1R)in nasal mucosa tissue from patients with intranasal mucosal contact point headaches. Methods The expression of NK-1R was detected by immunohistochemical staining method in mucosal contact points and non-contact point from 18 patients respectively. The mRNA level of NK-1R and substance P(SP)was detected by real-time quantitative reverse transcription polymerase chain reaction(RT-PCR)at NK-1R positive cells at mucosal contact point and non-contact point respectively. Results NK-1R was mainly located in acinar epithelial cells, inflammatory cells and nerve fiber of contact point nasal mucosa. The mRNA of SP and NK-1R were up-regulated in mucosal contact point compared with those in mucosal non-contact point. Conclusion NK-1R, as a mediator of pain transmission, may play an important role in the occurrence of intranasal mucosal contact point headaches.

Key words: Mucosal contact point headaches, Substance P, Neurokinin-1 receptor

CLC Number: 

  • R765.25
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