JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2016, Vol. 30 ›› Issue (2): 102-105.doi: 10.6040/j.issn.1673-3770.0.2015.391

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Advances on genetic polymorphism of DNA double-strand break repair genes and thyroid carcinoma.

LI Yingying1,2, SONG Xicheng   

  1. 1. Binzhou Medical University, Yantai 264000, Shandong, China;2. Department of Otolaryngology &Head and Neck Surgery, Yantai Yuhuangding Hospital, Medical College of Qingdao University, Yantai 264000, Shandong, China
  • Received:2015-09-17 Online:2016-04-16 Published:2016-04-16

Abstract: Failure to repair DNA damage timely and effectively can lead to genome instability, which is directly related to the occurrence of tumor. DNA double-strand break(DSB)is the predominant cause of gene mutation and chromosome fragmentation. It affects the tumor susceptibility and process of carcinogenesis. The DSB repair depends mainly on homologous recombination(HR)and non-homologous end-joining(NHEJ). This paper aims to investigate the correlation between the DSB repair gene polymorphism and thyroid carcinoma susceptibility.

Key words: DNA double-strand break, Recombination repair, Thyroid carcinoma

CLC Number: 

  • R736.1
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