JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2016, Vol. 30 ›› Issue (3): 40-46.doi: 10.6040/j.issn.1673-3770.0.2015.411

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Relationship between gastroesophageal reflux disease and laryngeal carcinoma: a meta-analysis.

LI Zewen1, GUO Junyu1, ZHOU Jie1, YAN Fubo1, YANG Zhimin2, DING Zhuhua   

  1. 1. Department of otorhinolaryngology, The Central Hospital of Xiaogan, Xiaogan 432100, Hubei, China;2. Department of ophthalmology and otorhinolaryngology, The First Peoples Hospital of Xiaogan, Xiaogan 432100, Hubei, China
  • Received:2015-10-09 Online:2016-06-16 Published:2016-06-16

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Abstract: Objective To evaluate the relationship between gastroesophageal reflux disease and laryngeal carcinoma with meta-analyses. Methods The published studies of the relationship between gastroesophageal reflux disease and laryngeal carcinoma were searched in the Pubmed、Embase、Web of Knowledge、CBM and CNKI databases(from the date of establishment of the databases to May 2015). The trails selection based on inclusion and exclusion criteria, the quality of the included studies was assessed and meta-analysis was performed with RevMan 5.3 and Stata 13.1 software. The OR value of included studies were calculated after heterogeneity test and publication bias was assessed by Harbord method. Results A total of 13 studies were recruited. The Meta-analysis showed the positive rate of gastroesophageal reflux disease was significantly higher in the laryngeal carcinoma group compared with the control group ［OR=2.68, 95%CI(1.94, 3.70), P<0.000 01］. Conclusion Gastroesophageal reflux disease may be a significant risk factor for laryngeal carcinoma. However, given the heterogeneity of the published studies, future well-designed studies are needed.

Key words: Case-control study, Laryngeal carcinoma, Meta-analysis, Gastroesophageal reflux disease

CLC Number: 

  • R739.6
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