JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2015, Vol. 29 ›› Issue (6): 36-38.doi: 10.6040/j.issn.1673-3770.0.2015.202

Previous Articles     Next Articles

Expression of tumor suppressor in lung cancer 1 in laryngeal squamous cell carcinoma and its significance

LI Fu1, ZHAO Shuyou2   

  1. 1. Department of Otolaryngology, First Affiliated Hospital of Baotou Medical College, Baotou 014010, Inner Mongolia, China;
    2. Department of Otolaryngology & Head and Neck Surgery, Qingdao Municipal Hospital, Qingdao 266011, Shandong, China
  • Received:2015-05-25 Online:2015-12-16 Published:2015-12-16

PDF (PC)

265

Abstract: Objective To investigate the correlation of tumor suppressor in lung cancer 1 (TSLC1) and laryngeal squamous cell carcinoma, in order to provide a theoretic basis of oncogenesis, diagnosis and treatment of laryngeal cancer. Methods Paraffin-embedded specimens were collected from 45 cases of laryngeal squamous cell carcinoma, 8 of which had lymphatic metastasis. Another 20 specimens from normal adjacent tissues served as controls. The expression of TSLC1 was detected with immunohistochemical staining (PV-6000). The relation between TSLC1 expression and other clinicopathological parameters was analyzed with SPSS 10.0. Results The positive expression of TSLC1 was 17/45 (37.8%) in specimens of laryngeal squamous cell carcinoma, which was significantly lower than in specimens of normal adjacent tissues (15/20, 75%), (χ2=7.68, P<0.01). Loss of TSLC1 expression was correlated with the clinical stage, tumor differentiation and lymph node metastasis (χ2=4.15, 6.11, 4.11, P<0.05), but not correlated with patients' age, gender, or location of primary laryngeal carcinoma (χ2= 0.25, 0.09, 1.0, P>0.05). Conclusion Loss of TSLC1 expression is frequently observed in laryngeal squamous cell carcinoma, which is significantly correlated to the clinical stage, tumor differentiation and lymph node metastasis. The down-regulation of TSLC1 expression may correlate with the occurrence and invasion of laryngeal squamous cell carcinoma, but more studies are needed to verify the hypothesis.

Key words: Laryngeal carcinoma, Tumor suppressor in lung cancer 1, Immunohistochemistry

CLC Number: 

  • R739.65
[1] 黄选兆, 汪吉宝. 实用耳鼻咽喉科学[M]. 北京: 人民卫生出版社, 1998: 502-508.
[2] Goto A, Niki T, Chi-Pin L, et al. Loss of TSLC expression in lung adenocarcinoma: relationships with histological subtypes, sex and prognostic significance[J]. Cancer Sci, 2005, 96(8):480-486.
[3] [JP2]Tamura G. Alterations of tumor suppressor and tumor-related genes in the development and progression of gastric cancer[J]. World J Gastroenterol, 2006, 12(2):192-198.
[4] Uchino K, Ito A, Wakayama T, et al. Clinical implication and prognostic significance of the tumor suppressor TSLC1 gene detected in adenocarcinoma of the lung[J]. Cancer, 2003, 98(5):1002-1007.
[5] Lung H L, Cheung A K, Xie D, et al. TSLC1 is a tumor suppressor gene associated with metastasis in nasopharyngeal carcinoma[J]. Cancer Res, 2006, 66(19):9385-9392.
[6] Liu D, Feng X, Wu X, et al. Tumor suppressor in lung cancer 1 (TSLC1), a novel tumor suppressor gene, is implicated in the regulation of proliferation, invasion, cell cycle, apoptosis, and tumorigenicity in cutaneous squamous cell carcinoma[J]. Tumour Biol, 2013, 34(6):3773-3783.
[7] Fukuhara H, Kuramochi M, Fukami T, et al. Promoter methylation of TSLC1 and tumor suppression by its gene product in human prostate cancer[J]. Jpn J Cancer Res, 2002, 93(6):605-609.
[8] Allinen M, Peri L, Kujala S, et al. Analysis of 11q21-24 loss of heterozygosity candidate target genes in breast cancer: indications of TSLC1 promoter hypermethylation[J]. Genes Chromosomes Cancer, 2002, 4(4):384-389.
[9] Ito T, Shimada Y, Hashimoto Y, et al. Involvement of TSLC1 in progression of esophageal squamous cell carcinoma[J]. Cancer Res, 2003, 63(19):6320-6326.
[10] Zhang J, Ning J, Geng J, et al. Down-regulation of tumor suppressor in lung cancer 1 (TSLC1) expression correlates with poor prognosis in patients with colon cancer[J]. J Mol Histol, 2012, 43(6):715-721.
[1] YE Shufeng, ZHANG Xu, SU Kai, LI Hejie, TENG Bo. Laryngocelesecondary to Laryngectomy:a case report and literature review [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(5): 117-118.
[2] LI Guobin, ZHANG Zhancheng, WANG Xinyan. Up-regulation of miR-200b may inhibit epithelial mesenchymal transition process to prevent the proliferation, migration, and invasion of human laryngeal cancer Hep-2 cells [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(4): 53-57.
[3] LI Hao, LI Yanzhong, WANG Yan. Hypoxia inducible factor-1 alpha and vascular endothelial growth factor expression in the soft palate of [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(2): 43-47.
[4] ZHANG Menglu, LI Yongtuan.. Expression of chemokine ligand 27 in secondary middle ear cholesteatoma. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(6): 46-48.
[5] AN Yongming, MU Wenli, TIAN Yanxun, LI Wei, WU Yanqiao. The significance of Maspin and Ets1 in laryngeal squamous carcinoma. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(3): 91-94.
[6] LI Zewen, GUO Junyu, ZHOU Jie, YAN Fubo, YANG Zhimin, DING Zhuhua. Relationship between gastroesophageal reflux disease and laryngeal carcinoma: a meta-analysis. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(3): 40-46.
[7] CHEN Xiaoling, FEI Bing, LI Xianbin, WU Hao. Construction and identification of small interfering RNA targeting silence Trop2 expression in human laryngeal carcinoma cell line HEP2 [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2015, 29(3): 51-53.
[8] WEI Xi-jian1, YIN Rui-lan2, GUO Xing3. Expression of a proliferation-inducing ligand in laryngeal squamous cell carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2014, 28(1): 14-16.
[9] XU Zhen1, YU Hai-ling1, LIU Bing2. Expression and significance of aquaporin-4 in nasal polyps [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2014, 28(1): 48-50.
[10] CHEN Zhi-xi1, LIU Yang-yun2, ZHOU Wen-fang1, ZHANG Jin-ping1, LUO Xu-yong1, YE Xue-meng1, XIONG Qi-bin1, LIU Huo-wang3. Diagnosis, treatment and biocharacteristics of myoepithelial Carcinoma in head and neck [J]. J Otolaryngol Ophthalmol Shandong Univ, 2013, 27(6): 22-25.
[11] L Feng， LI Yong-tuan. Expression and significance of CyclinD1 in middle ear cholesteatoma [J]. J Otolaryngol Ophthalmol Shandong Univ, 2013, 27(2): 13-15.
[12] QIAN Ye, LEI Da-peng, JIN Tong, LIU Da-yu, XU Feng-lei, PAN Xin-liang. Expression of Slit2 and its correlation with lymphatic vessel density in hypopharyngeal squamous cell carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2012, 26(5): 12-15.
[13] SHEN Bin, DONG Pin, YING Xin-jiang, GAO Shang, LI Da-wei. Expressions and implication of ABCG2 and NF-κB p65 in hypopharyngeal cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2012, 26(4): 17-20.
[14] BAI Yong1， LI Na2， ZHAO Shen-lin1， ZHANG Min1. Effect of Azithromycin on NF-kBp65 and IL-8 in nasal mucosa of chronic sinusitis after endoscopic sinus surgery [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2012, 26(3): 40-44.
[15] PAN Chun-chen1, ZHANG Xiao-peng2, LAI Hai-chun3, WANG De-sheng3. Expression and  relationship of HMGA1 and Ezrin in laryngeal carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2012, 26(2): 27-31.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd