JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2016, Vol. 30 ›› Issue (2): 98-101.doi: 10.6040/j.issn.1673-3770.0.2015.550

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Progress of intracellular signaling pathways regulating ciliary length.

WANG Jing1, WANG Xuesong2, XUE Jinmei   

  1. 1. Shanxi Medical University, Taiyuan 030001, Shanxi, China;2. Department of Otolaryngology, Binzhou Central Hospital, Binzhou 251700, Shandong, China;3. Department of Otolaryngology, Second Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi, China
  • Received:2015-12-29 Online:2016-04-16 Published:2016-04-16

Abstract: Cilia are located on almost all cell types of the human body, and perform key tasks for a variety of organs, but defects in the length or function of them are involved in the pathogenesis of several cilia-related disorder.Ciliary length can be regulated by the process of intraflagellar transport(IFT), signal transduction pathways,cell cycle,etc.All of these stages are tightly regulated to produce a cilium of the right size at the right time.Signaling regulation involves cAMP, NF-κB, Wnt, Shh and Notch.To further explore intracellular molecules that regulate ciliary length is of great importance for the diagnosis and treatment of certain cilia-related disorder.

Key words: Ciliary length, Cilia, Signal pathways

CLC Number: 

  • Q471
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