Abstract: Objective To discuss the clinical efficacy and safety of nasal glucocorticoid-assisted endoscopic adenoidectomy in the treatment of adenoidal hypertrophic snoring in children. Methods Ninety-eight cases of children with adenoidal hypertrophic snoring were randomly divided into control and observation groups, with 49 cases in each group. While patients in the control group were treated with endoscopic adenoidectomy, Cefaclor Granules by oral administration, dexamethasone by inhalation, and other conventional treatments, patients in the observation group were treated with a nasal glucocorticoid. The treatment efficiency, incidence of adverse events, A/N of nasopharynx lateral radiograph, apnea-hypopnea index, sleep quality, and levels of immune and inflammatory factors before and after treatment were compared between the two groups. Results The total effective rate of treating adenoidal hypertrophic snoring was noted to be 89.80%(44/49)and 73.47%(36/49)for the observation and control group respectively. This rate in the observation group was significantly higher than that in the control group(χ2=4.356, P=0.037). There was 1 case of nasal bleeding and 1 case of nasal vestibule dryness sensation reported in the observation group, with a 4.08% incidence rate of adverse reactions in this group. On the contrary, no nasal bleeding and nasal vestibule dryness was reported in the control group and there was no significant difference in the incidence rate of adverse reactions between the two groups(P>0.05). Before treatment, there were no significant differences in A/N of nasopharynx lateral radiograph, apnea-hypopnea index, and sleep quality between the two groups(P>0.05). After treatment, the A/N of nasopharynx lateral radiograph, apnea-hypopnea index, and sleep quality of the two groups were all improved, and there was a significant difference between the two groups(P<0.05). Before treatment, there were no significant differences in IgE, LTE4, TNF-α, IL-6, and IL-8 levels between the two groups(P>0.05). After treatment, the levels of IgE, LTE4, TNF-α, IL-6, and IL-8 in the two groups decreased, and there was a significant difference between the two groups(P<0.05). Conclusion This study reported that nasal glucocorticoid-assisted endoscopic adenoidectomy inhibited the inflammatory factors and reduced snoring, nasal congestion, and other clinical symptoms, with little risk and improved sleep quality, in children with adenoid hypertrophy snoring and can be worth popularizing.

Key words: Clinical effect, Adenoid hypertrophy, Nasal glucocorticoid, Surgical treatment, Snoring in children