Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2018, Vol. 32 ›› Issue (6): 84-87.doi: 10.6040/j.issn.1673-3770.0.2017.509

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Clinical effect of combination therapy of sodium hyaluronate and recombinant bovine basic fibroblast growth factor on dry eye after phacoemulsification

TU Xuefeng   

  1. Department of Ophthalmology, Shunde Hospital Affiliated to Guangzhou Medical University, Foshan 528315, Guangdong, China
  • Published:2018-11-29

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Abstract: Objective To analyze the effect of sodium hyaluronate(SH)and recombinant bovine basic fibroblast growth factor(r-bFGF)on tear film of dry eye after phacoemulsification surgery. Methods Among patients diagnosed with dry eye within one month of phacoemulsification surgery who presented to our hospital between July 2014 and June 2017, 96 cases(102 eyes)were randomly divided into a treatment group(48 cases, 50 eyes)and a control group(48 cases, 52 eyes). All enrolled patients underwent dry eye examination and grading. The control group was administered 0.1% SH, while the treatment group was treated with eye drops containing SH and r-bFGF. After one month of treatment, all patients underwent dry eye-related examination and grading again. Results No statistically significant differences were observed in any of the indexes between the two groups before initiating treatment. After treatment, the Schirmer I test results, non-invasive tear film break-up time, tear meniscus height, corneal fluorescein staining and ocular symptoms scores of the treatment group were significantly better than those of the control group, with a statistically significant difference. Difference in the tear film lipid layer scores between the treatment and control groups was not statistically significant. Conclusion SH combined with r-bFGF has a significant effect on dry eye after phacoemulsification surgery.

Key words: Phacoemulsification, Dry eye, Recombinant bovine basic fibroblast growth factor

CLC Number: 

  • R777.34
[1] Kaido M, Tsubota K. Dry Eye: Future Directions and Research[M]. Berlin:Springer Berlin Heidelberg, 2015:85-101.
[2] Su TY, Ho WT, Lu CY, et al. Correlations among ocular surface temperature difference value, the tear meniscus height, Schirmers test and fluorescein tear film break up time[J]. Br J Ophthalmol, 2015, 99(4):482-487.
[3] Grus FH, Augustin AJ, Evangelou NG, et al. Analysis of tear-protein patterns as a diagnostic tool for the detection of dry eyes[J]. Eur J Ophthalmol, 2016, 8(2):90-97.
[4] Conrady CD, Joos ZP, Patel BC. Review: the lacrimal gland and its role in dry eye[J]. J Ophthalmol, 2016:7542929. DOI: 10.1155/2016/7542929.
[5] 熊婵, 刘珍凯, 纪开宝,等. 视屏终端的使用对人泪膜及眼表的影响及非侵入性眼表综合分析仪的应用价值[J]. 中华实验眼科杂志, 2016, 34(5):443-447. XIONG Chan, LIU Zhenkai, JI Kaibao, et al. Influence of watching video display terminal on ocular surface and application of non-invasive ocular surface analyzer[J]. Chin J Exp Ophthalmol, 2016, 34(5):443-447.
[6] Han KE, Yoon SC, Ahn JM, et al. Evaluation of dry eye and meibomian gland dysfunction after cataract surgery[J]. Am J Ophthalmol, 2014, 157(6):1144-1150.
[7] González-Mesa A, Moreno-Arrones JP, Ferrari D, et al. Role of tear osmolarity in dry eye symptoms after cataract surgery[J]. Am J Ophthalmol, 2016, 170:128-132. DOI: 10.1016/j.ajo.2016.08.002.
[8] Sutu C, Fukuoka H, Afshari NA. Mechanisms and management of dry eye in cataract surgery patients[J]. Curr Opin Ophthalmol, 2015, 27(1):24-30.
[9] Szakáts I, Sebestyén M, Tóth é, et al. Dry Eye Symptoms, patient-reported visual functioning, and health anxiety influencing patient satisfaction after cataract surgery[J]. Curr Eye Res, 2017, 42(6):832-836.
[10] 中华医学会眼科学分会角膜病学组. 干眼临床诊疗专家共识(2013年)[J]. 中华眼科杂志, 2013, 49(1):73-75.
[11] 赵慧, 刘祖国, 杨文照,等. 我国干眼问卷的研制及评估[J]. 中华眼科杂志, 2015, 51(9):647-654. ZHAO Hui, LIU Zuguo, YANG Wenzhao, et al. Development and assessment of a dry eye questionnaire applicable to the Chinese population[J]. Chin J Ophthalmol, 2015, 51(9):647-654.
[12] 于世伟, 夏媛玲. 糖尿病白内障患者行超声乳化吸除及人工晶状体植入术后房水NO水平[J]. 贵阳医学院学报, 2017, 42(8):937-941. YU Shiwei, XIA Yuanling. The level of aqueous humor no after phacoemulsification and hsm implantation in diabetic cataract patients[J]. Guizhou Med Univ, 2017, 42(8):937-941.
[13] 沈沛阳, 陈海波, 刘红山,等. Keratograph眼表综合分析仪与传统方法对泪膜功能评价的一致性分析[J]. 国际眼科杂志, 2015(5):846-849. SHEN Peiyang, CHEN Haibo, LIU Hongshan, et al. Consistency analysis of Keratograph and traditional methods to evaluate tear film function[J]. Int Eye Sci, 2015(5):846-849.
[14] Koh S, Ikeda C, Watanabe S, et al. Effect of non-invasive tear stability assessment on tear meniscus height[J]. Acta Ophthalmol, 2015, 93(2):135-139.
[15] Abdelfattah NS, Dastiridou A, Sadda SR, et al. Noninvasive imaging of tear film dynamics in eyes with ocular surface disease[J]. Cornea, 2015, 10(10):48-52.
[16] 李妍, 桑璇, 王晓然,等. 干眼患者泪膜脂质层厚度检测及其与眼表体征的相关性分析[J]. 眼科新进展, 2017, 37(4):344-347. LI Yan, SANG Xuan, WANG Xiaoran, et al. Measurement of tear film lipid layer thickness in dry eye patients and its relationship with ocular surface signs[J]. Recent Adv Ophthalmol, 2017, 37(4):344-347.
[17] 杨丽萍, 李俊莲, 郭凯. 不同药物治疗白内障术后干眼症的疗效比较[J]. 国际眼科杂志, 2017, 17(2):298-301. YANG Liping, LI Junlian, GUO Kai. Analysis on therapy efficacy of different drugs for dry eyes after cataract surgery[J]. Int Eye Sci, 2017, 17(2):298-301.
[18] Purslow C. Evaluation of the ocular tolerance of a novel eyelid-warming device used for meibomian gland dysfunction[J]. Cont Lens Anterior Eye, 2013, 36(5):226-231.
[19] Yang YL, Yang YJ, Li P, et al. Clinical study Carbomer eye gel and rhEGF in treating dry eye after cataract surgery in diabetics[J]. Int Eye Sci, 2014, 14(9):1656-1658.
[20] 刘院斌, 武忠华, 郭俊儿,等. 重组牛碱性成纤维细胞生长因子对白内障超声乳化联合IOL植入术后干眼的治疗[J]. 中华实验眼科杂志, 2016, 34(2):175-180. LIU Yuanbin, WU Zhonghua, GUO Jun'er, et al. Efficacy of recombinant bovine basic fibroblast growth factor in treatment of dry eye following phacoemulsification with IOL implantation[J]. Chin J Exp Ophthalmol, 2016, 34(2):175-180.
[21] 杨楠. 重组牛bFGF对超声乳化联合IOL植入术后干眼的疗效[J]. 国际眼科杂志, 2016, 16(9):1732-1734. YANG Nan. Effect of recombinant bovine basic fibroblast growth factor in treatment of dry eye after cataract phacoemulsification combined with intraocular lens implantation[J]. Int Eye Sci, 2016, 16(9):1732-1734.
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[2] LI Houxiu, LIU Zhonghua, CHEN Zhi. Risk factors for rupture of the capsule membrane during phacoemulsification cataract surgery [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(2): 88-90.
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[4] ZHENG Wanqiu, WAN Wenjuan, LI Can. Application of anterior chamber maintainer in posterior capsular rupture in cataract surgery. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(4): 9-12.
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[6] HU Jindong, LIU Xinquan. Research progress of dry eye animal model. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(4): 109-113.
[7] DENG Zhifeng. The clinical study on the improved phacoemulsification. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(3): 85-88.
[8] JIANG Yang, LI Ying, WANG Zhonghai, JIN Yumei, LIU Xiaowei. Effect of the implantation of lacrimal plug for dry eyes after laser assisted in-situ keratomiLeusis. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(2): 80-83.
[9] SHAO Na, ZHANG Han. Variation of visual acuity and fundus in type 2 diabetic patients after phacoemulsification surgery. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(1): 83-87.
[10] WANG Luping, WU Xinyi. Effect of glycosylated hemoglobin on dry eye in patients with type 2 diabetes mellitus [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2015, 29(6): 71-73.
[11] LIU Zhao, WU Changrui, GAO Ning. Evaluation of meibomian gland dysfunction after phacoemulsification surgery [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2015, 29(6): 68-70.
[12] ZHANG Ju, WU Xin-yi. Effects of 01% cyclosporin eye drops in combination with sodium hyaluronate eye drops in the treatment of dry eye syndrome [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2015, 29(1): 49-51.
[13] SUN Hong-yi, ZHANG Han. Changes of macular thickness under optical coherent tomography in type 2 diabetic patients with cataract after phacoemulsification surgery and IOL implantation [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2014, 28(6): 72-76.
[14] FANG Xiu-ling, JIANG Hu-lin, WU Jian-xia, HAN Xu-wei, ZHANG Liao. Pre-operative irrigation of conjunctival sac using 0.5% povidone-iodine in preventing endophthalmitis after cataract surgery [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2014, 28(5): 66-67.
[15] ZHANG Ai-hui1， ZHU Ling1, ZHANG Jin-zhi1， ZHANG Wei2. Correlation between cataract phacoemulsification with intraocular lens implantation and age-related macular degeneration [J]. J Otolaryngol Ophthalmol Shandong Univ, 2013, 27(5): 77-83.
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