Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2018, Vol. 32 ›› Issue (6): 84-87.doi: 10.6040/j.issn.1673-3770.0.2017.509

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Clinical effect of combination therapy of sodium hyaluronate and recombinant bovine basic fibroblast growth factor on dry eye after phacoemulsification

TU Xuefeng   

  1. Department of Ophthalmology, Shunde Hospital Affiliated to Guangzhou Medical University, Foshan 528315, Guangdong, China
  • Published:2018-11-29

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Abstract: Objective To analyze the effect of sodium hyaluronate(SH)and recombinant bovine basic fibroblast growth factor(r-bFGF)on tear film of dry eye after phacoemulsification surgery. Methods Among patients diagnosed with dry eye within one month of phacoemulsification surgery who presented to our hospital between July 2014 and June 2017, 96 cases(102 eyes)were randomly divided into a treatment group(48 cases, 50 eyes)and a control group(48 cases, 52 eyes). All enrolled patients underwent dry eye examination and grading. The control group was administered 0.1% SH, while the treatment group was treated with eye drops containing SH and r-bFGF. After one month of treatment, all patients underwent dry eye-related examination and grading again. Results No statistically significant differences were observed in any of the indexes between the two groups before initiating treatment. After treatment, the Schirmer I test results, non-invasive tear film break-up time, tear meniscus height, corneal fluorescein staining and ocular symptoms scores of the treatment group were significantly better than those of the control group, with a statistically significant difference. Difference in the tear film lipid layer scores between the treatment and control groups was not statistically significant. Conclusion SH combined with r-bFGF has a significant effect on dry eye after phacoemulsification surgery.

Key words: Phacoemulsification, Dry eye, Recombinant bovine basic fibroblast growth factor

CLC Number: 

  • R777.34
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