Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (5): 129-131.doi: 10.6040/j.issn.1673-3770.0.2017.515

• Original Article • Previous Articles    

Morphological structure analysis of the macular area after anti-VEGF treatment for short-term retinal vein occlusion

Keyang HAN1,Beibei YU2,Bojun ZHAO3()   

  1. 1. Department of Ophthalmology, Zaozhuang Hospital, Beijing University of Chinese Medicine, Zaozhuang 277000, Shandong, China
    2. Tengzhou Traditional Chinese Medicine Hospital, Zaozhuang 277500, Shandong, China
    3. Department of Ophthalmology, Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China
  • Received:2017-12-08 Revised:2018-01-04 Online:2019-09-20 Published:2019-10-15
  • Contact: Bojun ZHAO E-mail:zhaobojun@hotmail.com

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Abstract: Objective

To observe the morphological changes in the macular area in patients with macular edema secondary to retinal vein occlusion after intravitreal injection of anti-vascular endothelial growth factor (VEGF) drugs, using optical coherence tomography (OCT).

Methods

Fifty-six patients with retinal vein occlusion complicated with macular edema were randomly selected from the clinic. An intravitreal injection with 0.05ml of an anti-VEGF drug was administered. OCT was performed before and 7 days after the intervention. The relationship between the best corrected visual acuity, neuroepithelial effusion, external membrane, ellipsoidal band, and choroidal thickness was assessed.

 Results

The best corrected visual acuity improved significantly from 0.89±0.52 to 0.56±0.46. The neuroepithelial effusion decreased from 66% to 29%; the structural integrity of the external membrane and ellipsoidal zone significantly improved from 0.88±0.79 and 0.86±0.72 to 0.30±0.54 and 0.21±0.41, respectively. The choroid thickness did not change significantly with preoperative short-term treatment (318.18±47.42) or postoperatively (320.54±45.55).

 Conclusion

Patients with retinal vein occlusion secondary to macular edema with short-term morphological changes in the macular area showed improvement in visual acuity after the injection of anti-VEGF drugs, with no significant effect on the choroid.

Key words: Retinal vein occlusion, Macular edema, Anti-VEGF, Retinal micro-structural changes

CLC Number: 

  • R774

Table 1

Analysis of retinal morphology in the macular area"

BCVA（LogMAR） 神经上皮层下积液（%） 外界膜 椭圆体带 脉络膜厚度（μm）
治疗前 0.89±0.52 66% 0.88±0.79 0.86±0.72 318.18±47.42
治疗后 0.56±0.46 29% 0.30±0.54 0.21±0.41 320.52±45.55
P ＜ 0.001 - ＜ 0.001 ＜ 0.001 0.621
r 7.599 - 6.024 7.156 -0.497

Table 2

efficacy analysis"

用药 疗效 n P
治愈 未愈
BCVA 康博西普 20 7 27 0.057
雷珠单抗 27 2 29
神经上皮层下积液 康博西普 12 8 20 0.520
雷珠单抗 10 8 18
外界膜 康博西普 16 1 17 0.225
雷珠单抗 32 5 37
椭圆体带 康博西普 16 2 18 0.669
雷珠单抗 16 2 18
1 Rouvas A , Petrou P , Ntouraki A , et al . Intravitreal ranibizumab (Lucentis) for branch retinal vein occlusion-induced macular edema: nine-month results of a prospective study[J]. Retina (Philadelphia, Pa ), 2010, 30(6): 893-902. doi:10.1097/IAE.0b013e3181cd4894 .
doi: 10.1097/IAE.0b013e3181cd4894
2 刘萍, 朱小华 . 可溶性血管内皮生长因子受体-1、2及其配体等因素在视网膜分支静脉阻塞黄斑水肿中的作用[J]. 山西医科大学学报, 2018, 49(12): 1505-1509. doi:10.13753/j.issn.1007-6611.2018.12.021 .
doi: 10.13753/j.issn.1007-6611.2018.12.021
3 Suzuki Y , Nakazawa M , Suzuki K , et al . Expression profiles of cytokines and chemokines in vitreous fluid in diabetic retinopathy and central retinal vein occlusion[J]. Jpn J Ophthalmol, 2011, 55(3): 256-263. doi:10.1007/s10384-011-0004-8 .
doi: 10.1007/s10384-011-0004-8
4 陈露, 李明新 . 玻璃体内注射雷珠单抗与康柏西普对视网膜静脉阻塞继发黄斑囊样水肿的疗效比较[J]. 中国眼耳鼻喉科杂志, 2019, 19(1): 26-30. doi:10.14166/j.issn.1671-2420.2019.01.010 .
doi: 10.14166/j.issn.1671-2420.2019.01.010
5 张敏, 朱健华, 冯浩, 等 . 视网膜静脉阻塞合并黄斑水肿患者黄斑区微结构改变与视力的相关性分析[J]. 眼科新进展, 2016, 36(11): 1061-1064. doi:10.13389/j.cnki. rao. 2016.0283 .
doi: 10.13389/j.cnki. rao. 2016.0283
6 杜玉芹 . 视网膜静脉阻塞治疗前后脉络膜厚度变化的分析[D]. 天津: 天津医科大学, 2016.
7 唐芬 . 黄斑水肿患者黄斑中心凹下脉络膜厚度的观察[D]. 长沙: 中南大学, 2014.
8 徐冲，冯超，吴建华 .OCTA在雷珠单抗抗体治疗视网膜分支静脉阻塞合并黄斑水肿视力预测的应用分析[J].临床眼科杂志，2018，26（5）：390-393. doi:10.3969/j.issn.1006-8422.2018.05.002 .
doi: 10.3969/j.issn.1006-8422.2018.05.002
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