Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (5): 129-131.doi: 10.6040/j.issn.1673-3770.0.2017.515

• Original Article • Previous Articles    

Morphological structure analysis of the macular area after anti-VEGF treatment for short-term retinal vein occlusion

Keyang HAN1,Beibei YU2,Bojun ZHAO3()   

  1. 1. Department of Ophthalmology, Zaozhuang Hospital, Beijing University of Chinese Medicine, Zaozhuang 277000, Shandong, China
    2. Tengzhou Traditional Chinese Medicine Hospital, Zaozhuang 277500, Shandong, China
    3. Department of Ophthalmology, Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China
  • Received:2017-12-08 Revised:2018-01-04 Online:2019-09-20 Published:2019-10-15
  • Contact: Bojun ZHAO E-mail:zhaobojun@hotmail.com

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Abstract: Objective

To observe the morphological changes in the macular area in patients with macular edema secondary to retinal vein occlusion after intravitreal injection of anti-vascular endothelial growth factor (VEGF) drugs, using optical coherence tomography (OCT).

Methods

Fifty-six patients with retinal vein occlusion complicated with macular edema were randomly selected from the clinic. An intravitreal injection with 0.05ml of an anti-VEGF drug was administered. OCT was performed before and 7 days after the intervention. The relationship between the best corrected visual acuity, neuroepithelial effusion, external membrane, ellipsoidal band, and choroidal thickness was assessed.

 Results

The best corrected visual acuity improved significantly from 0.89±0.52 to 0.56±0.46. The neuroepithelial effusion decreased from 66% to 29%; the structural integrity of the external membrane and ellipsoidal zone significantly improved from 0.88±0.79 and 0.86±0.72 to 0.30±0.54 and 0.21±0.41, respectively. The choroid thickness did not change significantly with preoperative short-term treatment (318.18±47.42) or postoperatively (320.54±45.55).

 Conclusion

Patients with retinal vein occlusion secondary to macular edema with short-term morphological changes in the macular area showed improvement in visual acuity after the injection of anti-VEGF drugs, with no significant effect on the choroid.

Key words: Retinal vein occlusion, Macular edema, Anti-VEGF, Retinal micro-structural changes

CLC Number: 

  • R774

Table 1

Analysis of retinal morphology in the macular area"

BCVA（LogMAR） 神经上皮层下积液（%） 外界膜 椭圆体带 脉络膜厚度（μm）
治疗前 0.89±0.52 66% 0.88±0.79 0.86±0.72 318.18±47.42
治疗后 0.56±0.46 29% 0.30±0.54 0.21±0.41 320.52±45.55
P ＜ 0.001 - ＜ 0.001 ＜ 0.001 0.621
r 7.599 - 6.024 7.156 -0.497

Table 2

efficacy analysis"

用药 疗效 n P
治愈 未愈
BCVA 康博西普 20 7 27 0.057
雷珠单抗 27 2 29
神经上皮层下积液 康博西普 12 8 20 0.520
雷珠单抗 10 8 18
外界膜 康博西普 16 1 17 0.225
雷珠单抗 32 5 37
椭圆体带 康博西普 16 2 18 0.669
雷珠单抗 16 2 18
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