JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2016, Vol. 30 ›› Issue (1): 80-82.doi: 10.6040/j.issn.1673-3770.0.2015.302

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Clinical analysis on intravitreal injection of conbercept in the treatment of macular edema secondary to branch retinal vein occlusion.

XING Kai1, KANG Zefeng   

  1. 1. Graduate School of Qinghai University, Xining 810016, Qinghai, China;2. Ophthalmology Clinic, Eye Hospital, China Academy of Chinese Medical Sciences, Beijing 100040, China
  • Received:2015-07-19 Online:2016-02-16 Published:2016-02-16

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Abstract: Objective To explore the clinical efficacy and safety of intravitreal injection of conbercept in the treatment of macular edema(ME)secondary to branch retinal vein occlusion(BRVO). Methods A total of 33 patients(38 eyes)with ME secondary to BRVO were selected as research objects, and injected Conbercept Ophthalmic Injection 0.05 mL through vitreous cavity. The optic examination was conducted at least once a month during 6-mongh follow-up. The central foveal thickness was measured to judge whether the injection was given again using optical coherence tomography(OCT). The best corrected visual acuity(BCVA)before and 1, 3 months after treatment as well as OCT results before and 1 month after treatment were compared, and the complications within 1 month after treatment were observed. Results The logarithm of minimum visual resolution(VA)was(0.59±0.21), and improved to(0.35±0.12)after the first injection(P<0.01). There was statistical significance regarding the BCVA before and 1, 3 months after treatment(P<0.05), and the BCVA 3 months after treatment was dramatically higher than that before treatment(P<0.05). The difference was statistically significant regarding the central foveal thickness of retina before and 1 month after treatment(P<0.05). Within 1 month after treatment, only 5 patients(15.15%)suffered from transient increase of intraocular pressure, no other eye-related events occurred. Conclusion For ME secondary to BRVO, intravitreal injection of conbercept based on OCT has definite short-term efficacy and better safety.

Key words: Conbercept, Macular edema, Branch retinal vein occlusion, Optical coherence tomography

CLC Number: 

  • R774
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