Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2020, Vol. 34 ›› Issue (1): 50-53.doi: 10.6040/j.issn.1673-3770.0.2019.357

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The prognostic value of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in intensity modulated radiation therapy for nasopharyngeal carcinoma

CHEN Xuesong, FU Weiwei, LIU Jiangtao   

  1. Department of Otorhinolaryngology, Binzhou Central Hospital, Huimin 251700, Shandong, China
  • Published:2020-03-06

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Abstract: Objective To evaluate the role of neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)in the prognosis of nasopharyngeal carcinoma(NPC). Methods A total of 120 patients with NPC undergoing intensity modulated radiation therapy(IMRT)from June 2012 to January 2014 were retrospectively included and their clinical information was obtained. The relationship between NLR, PLR, and overall survival(OS), progression-free survival(PFS), distant metastasis-free survival(DMFS), and local recurrence-free survival(LRF)was explored by correlation analysis, survival analysis, and multivariate regression analysis. Results The overall 5-year estimated OS, PFS, LRFS and DFS were 86.8%, 78.3%, 94.2%, and 85.3%, respectively. There was a significant association between NLR and T-stage, N-stage and tumor stage. PLR was also significantly associated with T-stage and tumor stage. NLR was shown to be an independent prognostic indicator for OS, PFS, DMFS. Conclusion NLR is an independent prognostic factor in nasopharyngeal carcinoma patients treated with IMRT.

Key words: Neutrophil-to-lymphocyte ratio, Platelet-to-lymphocyte ratio, Nasopharyngeal carcinoma, Prognosis

CLC Number: 

  • R739.6
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