Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2021, Vol. 35 ›› Issue (6): 77-82.doi: 10.6040/j.issn.1673-3770.0.2020.537

Previous Articles     Next Articles

Neuroendocrine carcinoma of the nasal cavity and paranasal sinus: eight cases and literature review

CHEN Xuejun, GAO Wen, YIN Gaofei, GUO Wei, HUANG Junwei, ZHANG Yang   

  1. Department of Otorhinolaryngology & Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University / Key Laboratory of Otolaryngology-Head and Neck Surgery, Ministry of Education, Beijing 100730, China
  • Published:2021-12-10

PDF (PC)

132

Abstract: ObjectiveTo investigate the clinical and pathological features, treatment, prognosis, and prognostic factors of neuroendocrine carcinoma of the nasal cavity and paranasal sinus. MethodsThe clinical data of 8 pathologically confirmed primary neuroendocrine carcinomas of the nasal cavity and paranasal sinus were reviewed. ResultsThe followup durations were 570 months, with a median of 23 months. Eight cases of nasal sinus neuroendocrine carcinoma were reviewed: 1 case of typical carcinoid tumor, 4 cases of atypical carcinoid tumor, 2 cases of small cell neuroendocrine carcinoma, and 1 case of complex neuroendocrine carcinoma (poorly differentiated neuroendocrine carcinoma with varus papilloma). The mean age of the patients was 46 years (3457 years). The stage of the malignant tumor in the nasal cavity and paranasal sinus was T2 in 2 patients and T4 in 6 patients. The cases were treated as follows: surgery, 7 cases; radiotherapy, 6 cases; and chemotherapy, 6 cases. Surgery plus postoperative chemoradiotherapy was the most common treatment. Conclusion The final diagnosis of neuroendocrine carcinoma depends on postoperative pathological and immunohistochemical indicators. The major adverse prognostic factors affecting the survival rate included the pathological subtypes and the associated treatment options. Surgical treatment is the first choice for typical and atypical carcinomas. For poorly differentiated subtypes of neuroendocrine carcinoma, comprehensive treatment is the most effective method for local tumor control and prolonged survival.

CLC Number: 

  • R739.62
[1] Van der Laan TP, Iepsma R, Witjes MJ, et al. Meta-analysis of 701 published cases of sinonasal neuroendocrine carcinoma: The importance of differentiation grade in determining treatment strategy[J].Oral Oncol, 2016,63:1-9. doi: 10.1016/j.oraloncology.2016.10.002.
[2] 陈红, 曹慧玲, 窦鑫, 等. 右侧鼻腔小细胞神经内分泌癌一例并文献复习[J]. 山东大学耳鼻喉眼学报, 2018,32(1): 89-92. doi: 10.6040 / j.issn.1673-3770.0.2017.300. CHEN Hong, CAO Huiling, DOU Xin, et al. Small cell neuroendocrine carcinoma in the right nasal cavity: a report of one case and a literature review[J]. J Otolaryngol Ophthalmol Shandong Univ, 2018,32(1): 89-92. doi: 10.6040/j.issn.1673-3770.0.2017.300.
[3] Jayme EM, Morimoto TP, Lozano TM, et al. Sphenoid sinus neuroendocrine carcinoma[J]. Bjr|case Rep, 2017, 3(1): 20150334. doi:10.1259/bjrcr.20150334.
[4] Mitchell EH, Diaz A, Yilmaz T, et al. Multimodality treatment for sinonasal neuroendocrine carcinoma[J]. Head Neck, 2012,34(10):1372-1376. doi: 10.1002/hed.21940.
[5] Mhawej R, Farah C, Haddad A, et al. Primary neuroendocrine tumors of the ear, nose and throat: A report of three cases and a review of the literature[J]. Oncol Lett, 2015,10(4):2533-2536. doi: 10.3892/ol.2015.3606.
[6] Gudlavalleti A, Dean R, Liu YX, et al. Diagnosis and treatment of a rare sinonasal neuroendocrine tumour: adding to the evidence[J]. BMJ Case Rep, 2016, 2016: bcr2016217319. doi:10.1136/bcr-2016-217319.
[7] Perez-Ordonez B, Caruana SM, Huvos AG, et al. Small cell neuroendocrine carcinoma of the nasal cavity and paranasal sinuses[J]. Hum Pathol, 1998, 29(8): 826-832. doi:10.1016/s0046-8177(98)90452-x.
[8] van der Laan TP, Plaat BE, van der Laan BF, et al. Clinical recommendations on the treatment of neuroendocrine carcinoma of the larynx: a meta-analysis of 436 reported cases[J]. Head Neck, 2015, 37(5): 707-715. doi:10.1002/hed.23666.
[9] 张洋, 段翰源, 李祖飞, 等. 25例喉神经内分泌癌的诊治与临床分析[J]. 肿瘤预防与治疗, 2019, 32(7): 607-611. doi:10.3969/j.issn.1674-0904.2019.07.009. ZHANG Yang, DUAN Hanyuan, LI Zufei, et al. Diagnosis, treatment and clinical analysis of 25 cases of laryngeal neu-roendocrine carcinoma[J]. J Cancer Control Treat, 2019, 32(7): 607-611. doi:10.3969/j.issn.1674-0904.2019.07.009.
[10] Shah K, Perez-Ordóñez B. Neuroendocrine neoplasms of the sinonasal tract: neuroendocrine carcinomas and olfactory neuroblastoma[J]. Head Neck Pathol, 2016, 10(1): 85-94. doi:10.1007/s12105-016-0696-7.
[11] 张青,朱庆强,吴晶涛,等.鼻窦神经内分泌癌的CT和MRI诊断[J].中华放射学杂志,2012(7):615-618. doi:10.3760/cma.j.issn.1005-1201.2012.07.008. ZHANG Qing, ZHU Qingqiang, WU Jingtao, et al. CT and MRI diagnosis of neuroendocrine carcinoma in paranasal sinuses[J]. Chinese Journal of Radiology, 2012(7):615-618. doi:10.3760/cma.j.issn.1005-1201.2012.07.008.
[12] Lahma J, Hejjouji R, Gicquel P, et al. Large cell neuroendocrine carcinoma of the nasal cavity: an extremely rare and new distinct entity[J]. Pan Afr Med J,2018,29(30):188. doi: 10.11604/pamj.2018.30.188.14992.
[13] 徐建明, 梁后杰, 秦叔逵, 等. 中国胃肠胰神经内分泌肿瘤专家共识(2016年版)[J]. 临床肿瘤学杂志, 2016,21(10): 927-946.
[14] 李采, 周梁, 沈雁, 等. 喉神经内分泌癌[J]. 临床耳鼻咽喉头颈外科杂志, 2009, 23(21): 970-972. doi:10.3969/j.issn.1001-1781.2009.21.004. LI Cai, ZHOU Liang, SHEN Yan, et al. Clinical analysis of laryngeal neuroendocrine carcinoma[J]. J Clin Otorhinolaryngol Head Neck Surg, 2009, 23(21): 970-972. doi:10.3969/j.issn.1001-1781.2009.21.004.
[15] Meacham R, Matrka L, Ozer E, et al. Neuroendocrine carcinoma of the head and neck: a 20-year case series[J]. Ear Nose Throat J, 2012, 91(3): E20-E24. doi:10.1177/014556131209100317.
[16] 徐丽, 关兵, 彭新, 等. 鼻窦低分化神经内分泌癌6例临床分析[J]. 临床耳鼻咽喉头颈外科杂志, 2013,27(5): 236-238. doi:10.13201/j.issn.1001-1781.2013.05.008. XU Li, GUAN Bing, PENG Xin, et al. Analysis on 6 cases with nasal neuroendocrine carcinoma[J]. J Clin Otorhinolaryngol Head Neck Surg, 2013,27(5): 236-238. doi:10.13201/j.issn.1001-1781.2013.05.008.
[17] Mills SE. Neuroectodermal neoplasms of the head and neck with emphasis on neuroendocrine carcinomas[J]. Mod Pathol, 2002, 15(3): 264-278. doi:10.1038/modpathol.3880522.
[18] Bell D. Sinonasal neuroendocrine neoplasms: current challenges and advances in diagnosis and treatment, with a focus on olfactory neuroblastoma[J]. Head Neck Pathol, 2018, 12(1): 22-30. doi:10.1007/s12105-018-0887-5.
[19] Furuta A, Kudo M, Kanai K, et al. Typical carcinoid tumor arising in the nose and paranasal sinuses-case report[J]. Auris Nasus Larynx, 2010, 37(3): 381-385. doi: 10.1016/j.anl.2009.09.007.
[20] Rivero A, Liang J. Sinonasal small cell neuroendocrine carcinoma: a systematic review of 80 patients[J]. Int Forum Allergy Rhinol, 2016, 6(7): 744-751. doi:10.1002/alr.21734.
[1] MA Jingyuan, WU Tianyi, SUN Zhanwei, WANG Weiwei, LI Shichao, WANG Guangke. Correlation between sinonasal inverted papilloma and peripheral inflammatory blood markers [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(4): 35-39.
[2] Jian FENG,Han ZHOU,Shenghua SONG,Qing ZHAO,Jiacheng ZHANG,Yaqin LIU,Yujie SHEN,Weida DONG. Clinical analysis of 15 cases of adenoid cystic carcinoma in the paranasal sinuses and nasal cavity [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(5): 87-91.
[3] YU Qianqian, GUAN Ge, ZHANG Niankai, LI Na, WEN Junfeng, LIU Tingting, LIAN Yuanyuan. Characteristics of respiratory epithelial adenomatoid hamartomas in the nasal olfactory cleft on computed tomography [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(3): 76-81.
[4] WANG Yuan, ZHOU Han, LIU Xiaojing, ZHANG Liqing, ZHAO Qing, FENG Jian, DONG Weida. Surgical strategies for nasal inverted papilloma and corresponding recurrence rates [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(2): 79-83.
[5] ZHANG Caixia, LIU Yangyun, JIANG Wen, LIU Gengxun, CAO Hang, CHEN Qiong, ZHANG Jishuai. Investigation of chemosensitization induced by nitric oxide on nasopharyngeal carcinoma CNE-2 cells. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(5): 72-78.
[6] . Construction of c-Met target chimeric antigen receptor T cells and evaluation the role on nasopharyngeal carcinoma cells. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(2): 49-54.
[7] . Advances in clinical diagnosis and treatment of sinonasal mucosal malignant melanoma. [J]. J Otolaryngol Ophthalmol Shandong Univ, 2017, 31(2): 116-120.
[8] ZHANG Meihua, ZHANG Niankai, SHAN Changsheng, LIU Tingting, LIAN Yuanyuan. Diagnostic value of CT of origin of nasal inverted papilloma. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(1): 43-46.
[9] ZHU Kang, HE Ying, YAN Jing, XIA Cui, GAO Ying, ZHENG Guo-xi, HOU Jin. Nasal endoscopy by low-temperature plasma radiofrequency for benign tumor resection [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2015, 29(2): 62-64.
[10] ZHOU Hui, HUANG Xue-qin, HU Jun-li, YAO Jun, ZHANG Yue-fei, JIANG Feng. Experimental study on Scutellarin influence DEX in the process of chemotherapy for nasopharyngeal carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2014, 28(4): 30-32.
[11] ZHANG Xiao-peng1, BIAN Feng2, WANG Li-xin2. Expressions and relativity of COX-2 and EGFR in nasopharyngeal carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2014, 28(3): 23-27.
[12] SHI Da-zhi1, LI Jian-ming2, LUO Zhi-qiang1, LUO Qin1, JING Qian-cheng1. Clinical analysis of nasopharyngeal carcinoma in pregnancy [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2014, 28(3): 28-30.
[13] LIN Dan, DONG Wei-da, LU Mei-ping, XING Guang-qian, DONG Jia-di, ZHANG Wei-qiang. The association between rs2910164 G>C polymorphism in pre-microRNA-146a and laryngeal cancer in Jiangsu Han population [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2014, 28(2): 46-50.
[14] ZHANG Zhong-hua1, WANG Xue-hai2, CAI Xiao-lan3. Expression and significance of p-PTEN， p-Akt and p-FoxO1 in nasopharyngeal carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2014, 28(2): 55-57.
[15] JIN Peng1, LI Chun-wei2, LI Ying-ying2, ZHAO Li1, WANG De-yun2， SHI Li3. Expression of EMP1 in sinonasal inverted papilloma and its relationship with metaplasia [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2014, 28(2): 72-75.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] LIN Bin,WANGHui-ge . Functional endoscopic sinus surgery, FESS[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(6): 481 -487 .
[2] GONG Lei,SUN Jie,XUE Zi-chao,LI Jing-hua,XUE Wei-guo . DNA analysis of the cell cycle in sino-nasal neoplasm[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 193 -195 .
[3] CHEN Wen-wen . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(5): 472 -472 .
[4] LUAN Jiangang,LIANG Chuanyu,WEN Yanjun,LI Jiong . Construction of RNAi expressing plasmid vector of pSIRENshuttle for EGFR gene silencing[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(1): 4 -8 .
[5] MA Jing, ZHONG Cui-ping . Surgical method for nasopharyngeal fibroangioma encroaching on fossa pterygopalatina: with a report of 5 cases[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(1): 30 -32 .
[6] LIU Qiang-he,LUO Xiang-lin,GENG Wan-ping,CHEN Chen,LEI Xun,LIU Fang-xian,DENG Ming . Age-related spiral ganglion neuron damages and hearing loss in senescence accelerated mice[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 215 -217 .
[7] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 223 -226 .
[8] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 246 -247 .
[9] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 250 -252 .
[10] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 260 -262 .
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd