Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2022, Vol. 36 ›› Issue (2): 157-162.doi: 10.6040/j.issn.1673-3770.0.2021.141

Previous Articles    

Research progress of optical coherence tomography and angiography in the diagnosis of Alzheimer's disease

ZHANG Min1Overview,LI Yan2Guidance   

  1. 1. School of Clinical Medicine, Weifang Medical University, Weifang 261053, Shandong, China;
    2. Ophthalmology Center, the Affiliated Hospital of Weifang Medical University, Weifang 261031, Shandong, China
  • Published:2022-04-15

Abstract: Alzheimer's disease(AD)is a progressive and irreversible neurological disease characterized by changes in neurons and blood vessels of the brain. Its etiology is unknown, and there is no feasible non-invasive technique for early diagnosis. Because the retina and the central nervous system have similar embryonic origins and physiological characteristics, an ophthalmic examination may provide a simple and non-invasive diagnostic method. Optical coherence tomography(OCT)can accurately measure the thickness of various tissue layers of the retina to assess degenerative changes of the retina. Optical coherence tomography angiography(OCTA)can provide high-resolution three-dimensional imaging, which can more directly detect the changes in retinal vessels and reflect the pathological characteristics of brain neurons and blood vessels noninvasively. This article mainly reviews the research progress of retinal thickness measured by means of OCT and retinal blood flow measured using OCTA in the diagnosis of AD.

Key words: Optical coherence tomography, Angiography, Alzheimer's disease, Retinal thickness, Vessel density

CLC Number: 

  • R741.02
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[1] ZHANG XinyuOverview,LEI Chunyan, ZHANG MeixiaGuidance. Retinochoriodal changes associated with silicone oil tamponade detected by optical coherence tomography and optical coherence tomography angiography [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(5): 132-136.
[2] Ocular ischemic syndrome(OIS)is a severe ophthalmic disease caused by ocular hypoperfusion, which occurs due to stenosis or occlusion of the common or internal carotid arteries. The clinical presentations and signs of OIS are complex, incidental, and different. OIS is easily misdiagnosed or remains undiagnosed because of its asymptomatic onset and complicated ocular manifestations. Therefore, it is crucial to trace the etiology of OIS. Presently, different imaging modalities can evaluate the carotid artery blood supply, collateral circulation, and brain perfusion. Thus, appropriate modalities must be selected for OIS diagnosis based on their advantages and disadvantages. Furthermore, the auxiliary examination results should be accurately and promptly considered and interpreted when establishing a diagnosis of OIS. Thus, the management of OIS requires cooperation with ophthalmologists, cardiologists, and neurologists.. Correct interpretation of the predictors of ocular ischemic syndrome to improve diagnostic performance HUANG Yingxiang, WANG Yanling Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China Abstract: [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(4): 1-4.
[3] Ocular ischemic syndrome(OIS)is usually undiagnosed or misdiagnosed due to its asymptomatic onset, complicated ocular manifestations, and the lack of awareness, and patients with OIS have a higher mortality. Improving the understanding, diagnosis, and treatment of OIS through multidisciplinary collaboration is key to investigating and preventing systemic vascular events as well as decreasing blindness and mortality. This review summarizes the recent advances in the epidemiology, clinical diagnosis, and management of OIS.. Recent ocular ischemic syndrome advancesWANG Luping Overview HUANG Yingxiang, WANG Yanling Guidance Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, ChinaAbstract: [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(4): 23-27.
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