Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2022, Vol. 36 ›› Issue (3): 202-208.doi: 10.6040/j.issn.1673-3770.0.2021.420

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Exploring the medication pattern of professor Ruan Yan in the treatment of chronic sinusitis based on data mining

LIU Zheng1,2, FANG Caishan1, MAO Shuxian3, LAN Wanning1, JIN Yan1,2, LIAO Bolin4, HUANG Danlin1, ZHONG Fangjian1, RUAN Yan2   

  1. 1. The First Clinical College, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China;
    2. Department of Pre-treatment, First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China;
    3. The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China;
    4. The Third Clinical College, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China;
    5. Department of Otolaryngology, First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China
  • Published:2022-06-15

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Abstract: Objective To analyze the medication patterns of Professor Ruan Yan of the First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine, for the treatment of chronic sinusitis, based on the Traditional Chinese Medicine(TCM)inheritance aid platform system. Methods Valid medical records of patients with chronic rhinosinusitis from Professor Ruan Yan's outpatient clinic were collected and collated. The medical cases that met the criteria were selected strictly according to the inclusion and exclusion criteria, and a medical case database was established. Subsequently, frequency statistics, association rule analysis, and cluster analysis were used to statistically analyze the distribution of evidence types, frequency of drugs, and combinations of Chinese medicines in the medical case repertoire. This was done to explore the characteristics of Professor Ruan Yan's treatment of chronic rhinosinusitis and the rules of prescription grouping. Results We collected 159 medical records of patients treated for chronic sinusitis by Professor Ruan Yan, containing 245 prescriptions with 109 Chinese herbs(except Stevia rebaudiana). The statistical analysis showed that the largest proportion of all cases was the spleen and stomach damp-heat evidence type; 24 herbs were used ≥20 times. The association rule analysis of high-frequency herbs yielded 13 associated pairs, 15 groups of three associated herbs, and four groups of four associated herbs. Additionally, seven potential core basic prescriptions and seven core new prescriptions for the treatment of chronic sinusitis were derived using cluster and factor analyses. Conclusion Most patients with chronic rhinosinusitis in Lingnan have evidence patterns consistent with climatic characteristics, with the majority of patients having the damp-heat evidence pattern of the spleen and stomach. Professor Ruan Yan considers deficiency and reality as the main pathogenesis based on his unique treatment method for chronic sinusitus. Additionally, Professor Ruan Yan is good at using the main treatment methods such as benefiting qi and strengthening the spleen, promoting nasal circulation, and clearing heat and dampness to achieve both the symptoms and the root cause of the disease according to local conditions. What'more, Xanthium Powder is the basic prescription of Professor Ruan Yan for treating chronic sinusitis.

Key words: Chronic sinusitis, Data mining, Medication pattern, Prescription pattern, Xanthium Powder

CLC Number: 

  • R276.1
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