Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2022, Vol. 36 ›› Issue (3): 202-208.doi: 10.6040/j.issn.1673-3770.0.2021.420

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Exploring the medication pattern of professor Ruan Yan in the treatment of chronic sinusitis based on data mining

LIU Zheng1,2, FANG Caishan1, MAO Shuxian3, LAN Wanning1, JIN Yan1,2, LIAO Bolin4, HUANG Danlin1, ZHONG Fangjian1, RUAN Yan2   

  1. 1. The First Clinical College, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China;
    2. Department of Pre-treatment, First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China;
    3. The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China;
    4. The Third Clinical College, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China;
    5. Department of Otolaryngology, First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China
  • Published:2022-06-15

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Abstract: Objective To analyze the medication patterns of Professor Ruan Yan of the First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine, for the treatment of chronic sinusitis, based on the Traditional Chinese Medicine(TCM)inheritance aid platform system. Methods Valid medical records of patients with chronic rhinosinusitis from Professor Ruan Yan's outpatient clinic were collected and collated. The medical cases that met the criteria were selected strictly according to the inclusion and exclusion criteria, and a medical case database was established. Subsequently, frequency statistics, association rule analysis, and cluster analysis were used to statistically analyze the distribution of evidence types, frequency of drugs, and combinations of Chinese medicines in the medical case repertoire. This was done to explore the characteristics of Professor Ruan Yan's treatment of chronic rhinosinusitis and the rules of prescription grouping. Results We collected 159 medical records of patients treated for chronic sinusitis by Professor Ruan Yan, containing 245 prescriptions with 109 Chinese herbs(except Stevia rebaudiana). The statistical analysis showed that the largest proportion of all cases was the spleen and stomach damp-heat evidence type; 24 herbs were used ≥20 times. The association rule analysis of high-frequency herbs yielded 13 associated pairs, 15 groups of three associated herbs, and four groups of four associated herbs. Additionally, seven potential core basic prescriptions and seven core new prescriptions for the treatment of chronic sinusitis were derived using cluster and factor analyses. Conclusion Most patients with chronic rhinosinusitis in Lingnan have evidence patterns consistent with climatic characteristics, with the majority of patients having the damp-heat evidence pattern of the spleen and stomach. Professor Ruan Yan considers deficiency and reality as the main pathogenesis based on his unique treatment method for chronic sinusitus. Additionally, Professor Ruan Yan is good at using the main treatment methods such as benefiting qi and strengthening the spleen, promoting nasal circulation, and clearing heat and dampness to achieve both the symptoms and the root cause of the disease according to local conditions. What'more, Xanthium Powder is the basic prescription of Professor Ruan Yan for treating chronic sinusitis.

Key words: Chronic sinusitis, Data mining, Medication pattern, Prescription pattern, Xanthium Powder

CLC Number: 

  • R276.1
[1] Fokkens WJ, Lund VJ, Hopkins C, et al. European position paper on rhinosinusitis and nasal polyps 2020[J]. Rhinology, 2020, 58(Suppl S29): 1-464. doi:10.4193/Rhin20.600.
[2] Cosway B, Tomkinson A, Owens D. The European positional paper on rhinosinusitis and nasal polyps: has the introduction of guidance on the management of sinus disease affected uptake of surgery and acute admissions for sinusitis? [J]. Eur Arch Oto Rhino Laryngol, 2013, 270(3): 889-892. doi:10.1007/s00405-012-2027-2.
[3] 田勇泉. 耳鼻咽喉头颈外科学[M]. 7版. 北京: 人民卫生出版社, 2008.
[4] 张宇, 宋西成. 慢性鼻窦炎伴鼻息肉与哮喘的相关性机制及治疗策略研究进展[J]. 山东大学耳鼻喉眼学报, 2019, 33(1): 49-52. doi: 10.6040/j.issn.1673-3770.1.2018.033. ZHANG Yu, SONG Xicheng. Advances in interaction mechanisms and treatment strategy between chronic rhinosinusitis with nasal polyp and asthma[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 49-52. doi: 10.6040/j.issn.1673-3770.1.2018.033.
[5] 杨钦泰, 孙悦奇, 吴庆武, 等. 2020年欧洲鼻窦炎和鼻息肉意见书解读[J]. 中华耳鼻咽喉头颈外科杂志, 2020, 55(3): 304-308. doi:10.3760/cma.j.issn.1673-0860.2020.03.024. YANG Qintai, SUN Yueqi, WU Qingwu, et al. Interpretation of 2020 European position paper on rhinosinusitis and nasal polyps[J]. Chinese Journal of Otorhinolaryngology Head and Neck Surgery, 2020, 55(3): 304-308. doi:10.3760/cma.j.issn.1673-0860.2020.03.024.
[6] 邓晗薇, 朱镇华. 朱镇华教授运用皂角刺治疗慢性鼻窦炎经验[J]. 亚太传统医药, 2020, 16(8): 91-93. doi:10.11954/ytctyy.202008027.
[7] 张蓉, 王旭. 基于现代文献的鼻-鼻窦炎中医证型及证候要素分布研究[J]. 湖南中医杂志, 2020, 36(9): 149-151. doi:10.16808/j.cnki.issn1003-7705.2020.09.062.
[8] 李莹. 慢性鼻窦炎的辨证论治[J]. 山东大学耳鼻喉眼学报, 2018, 32(3): 27-30. doi: 10.6040/j.issn.1673-3770.1.2017.056. LI Ying. Syndrome differentiation of chronic sinusitis[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2018, 32(3): 27-30. doi: 10.6040/j.issn.1673-3770.1.2017.056.
[9] 鄢宁, 朱镇华. 中医药治疗儿童慢性鼻窦炎研究进展[J]. 亚太传统医药, 2021, 17(5): 204-207. doi: 10.11954/ytctyy.202105056. YAN Ning, ZHU Zhenhua. Research progress of traditional Chinese medicine in the treatment of chronic rhinosinusitis in children[J]. Asia-Pacific Traditional Medicine, 2021, 17(5): 204-207. doi: 10.11954/ytctyy.202105056.
[10] 张辛群, 马金香, 史剑波, 等. 广州市社区居民慢性鼻窦炎家庭聚集性分析[J]. 中国公共卫生, 2015, 31(2): 168-171. doi:10.11847/zgggws2015-31-02-11. ZHANG Xinqun, MA Jinxiang, SHI Jianbo, et al. Family aggregation of chronic nasosinusitis among community residents in Guangzhou City[J]. Chinese Journal of Public Health, 2015, 31(2): 168-171. doi:10.11847/zgggws2015-31-02-11.
[11] 詹坚宏, 阮岩. 阮岩辨治慢性鼻窦炎经验[J]. 广州中医药大学学报, 2020, 37(11): 2219-2222. doi:10.13359/j.cnki.gzxbtcm.2020.11.030. ZHAN Jianhong, RUAN Yan. Experience of RUAN Yan in differentiating and treating chronic sinusitis[J]. Journal of Guangzhou University of Traditional Chinese Medicine, 2020, 37(11): 2219-2222. doi:10.13359/j.cnki.gzxbtcm.2020.11.030.
[12] 阮岩. 中西医结合耳鼻咽喉科学[M]. 广州: 广东高等教育出版社, 2007.
[13] 张勤修, 陈文勇. 中西医结合耳鼻咽喉科学[M]. 4版. 北京: 中国中医药出版社, 2021.
[14] 钟赣生. 中药学[M]. 北京: 人民卫生出版社, 2006.
[15] 韩慧莹, 刘桂荣. 张志远临证运用甘草经验[J]. 中医杂志, 2021, 62(2): 101-103, 113. doi:10.13288/j.11-2166/r.2021.02.003. HAN Huiying, LIU Guirong. ZHANG zhiyuan's experience in using Gancao(Radix et rhizoma glycyrrhizae)[J]. Journal of Traditional Chinese Medicine, 2021, 62(2): 101-103, 113. doi:10.13288/j.11-2166/r.2021.02.003.
[16] 樊青, 关建红. 5种临床常用辛味中药饮片急性毒性初探: 探讨毒性中药界定与分级标准的不足[J]. 世界中西医结合杂志, 2021, 16(8): 1443-1446, 1452. doi:10.13935/j.cnki.sjzx.210813. FAN Qing, GUAN Jianhong. A preliminary study on the acute toxicity of five kinds of pungent herbs commonly used in clinic-discuss the insufficiency of the definition and grading standards of toxic traditional Chinese medicines[J]. World Journal of Integrated Traditional and Western Medicine, 2021, 16(8): 1443-1446, 1452. doi:10.13935/j.cnki.sjzx.210813.
[17] 盛天露, 张祖良, 陈冠宜, 等. 苍耳草与苍耳子的研究进展[J]. 广州中医药大学学报, 2021, 38(12): 2812-2816. doi:10.13359/j.cnki.gzxbtcm.2021.12.044. SHENG Tianlu, ZHANG Zuliang, CHEN Guanyi, et al. Progress in the research of herba xanthii and fructus xanthii[J]. Journal of Guangzhou University of Traditional Chinese Medicine, 2021, 38(12): 2812-2816. doi:10.13359/j.cnki.gzxbtcm.2021.12.044.
[18] 冯彦. 丹参的现代药理研究及临床应用[J]. 中医临床研究, 2017, 9(30): 46-47. FENG Yan. Modern pharmacological study and clinical application of Radix salviae miltiorrhizae[J]. Clinical Journal of Chinese Medicine, 2017, 9(30): 46-47.
[19] 封若雨, 朱新宇, 邢峰丽, 等. 路路通的药理作用研究概述[J]. 中国中医基础医学杂志, 2019, 25(8): 1175-1178. FENG Ruoyu, ZHU Xinyu, XING Fengli, et al. Review of the research on the pharmacological effects of fructus liquidambaris[J]. Chinese Journal of Basic Medicine in Traditional Chinese Medicine, 2019, 25(8): 1175-1178.
[20] 陈李. 医碥全本校注与研究(精)/岭南珍本古医籍校注丛书[M]. 广州: 广东科技出版社, 2018.
[21] (清)叶桂. 温热论[M]. 上海: 第二军医大学出版社, 2012.
[22] (清)张隐庵集注,孙国中,方向红点校. 黄帝内经素问集注[M]. 北京: 学苑出版社, 2002.
[23] 周建辉, 张耀锋. 研究五指毛桃药理作用并与黄芪的益气作用相对比[J]. 中医临床研究, 2015, 7(33): 145-147. doi:10.3969/j.issn.1674-7860.2015.33.072. ZHOU Jianhui, ZHANG Yaofeng. Comparison of pharmacological studies of Radix fici hirtae Yiqi and Huangqi[J]. Clinical Journal of Chinese Medicine, 2015, 7(33): 145-147. doi:10.3969/j.issn.1674-7860.2015.33.072.
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