中药鼻腔冲洗治疗慢性鼻窦炎术后有效性和安全性的Meta分析

doi:10.6040/j.issn.1673-3770.0.2021.524

Abstract

Abstract: Objective To systematically evaluate the efficacy of nasal irrigation using traditional Chinese medicine(TCM)in treating chronic rhinosinusitis(CRS)after Functional Endoscopic Sinus Surgery(FESS)in the recent decade. Methods Using Chinese herbal irrigation, chronic rhinosinusitis, and randomized controlled trials as the key search terms,we searched the Pubmed、Web of science、the Cochrane Library、Embase、CNKI、VIP、CBM and Wanfang for related studies that were published for the recent ten years. We included randomized controlled trial articles about Chinese herbal irrigation as an intervention for chronic rhinosinusitis. The studies were screened strictly according to inclusion and exclusion criteria,and the quality was assessed; R software were used for data analysis. Results A total of 47 randomized controlled trials were included in the meta-analysis.These articles were divided into three groups. The meta-analysis showed that the total effective and cure rates of the TCM nasal irrigation group were higher than those of the saline irrigation and non-treatment control group. TheVAS score of the TCM nasal irrigation group was better than that for the other groups. Compared with the Western medicine irrigation and the non-treatment control group, the TCM nasal irrigation group reduced symptoms more effectively as evident by the symptom scores relating to nasal obstruction and hyposmia. The TCM nasal irrigation group also reduced the runny nose symptom score more effectively than the saline irrigation and non-treatment control groups. Comparing the saline irrigation,Western medicine irrigation, and blank control groups, there were no statistical differences in symptom scores relating to headache. The TCM irrigation group was superior to the control group in promoting postoperative nasal epithelialization,the Lund-Kennedy endoscopic score, and nasal mucosal ciliary transport rate. Safety was reported in 11 studies and no adverse reactions occurred. Conclusion TCM nasal irrigation is effective for the treatment of chronic sinusitis after surgery. Moreover, it is superior to isotonic saline irrigation, antibiotics, and hormone irrigation.TCM nasal irrigation should be considered in the clinical practice.

Key words: Traditional Chinese medicine, Nasal irrigation, Chronic rhinosinusitis, Meta-analysis, Evidence-based medicine

CLC Number:

R276.1

LIN Manqing, ZHOU Min, CHEN Tengyu, LI-Dan, FANG Caishan, WANG Ruizhi, ZHU Jinxiang, RUAN-Yan, XU Huixian, WANG Peiyuan. Meta-analysis of the efficacy and safety of traditional Chinese medicine for nasal irrigation in the treatment of chronic rhinosinusitis[J].Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 209-225.

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Meta-analysis of the efficacy and safety of traditional Chinese medicine for nasal irrigation in the treatment of chronic rhinosinusitis

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