Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2022, Vol. 36 ›› Issue (3): 165-170.doi: 10.6040/j.issn.1673-3770.0.2021.469

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Relationships between RANTES gene polymorphisms and chronic sinusitis with bilateral nasal polyps

LIU Houjun1, ZHANG Qian2, CHENG You1, XUE Fei1, XU Li1, WU Minghai1   

  1. 1. Department of Otorhinolaryngology & Head and Neck Surgery, Eastern Theater Command General Hospital, Nanjing 210000, Jiangsu, China;
    2. Department of Otorhinolaryngology & Head and Neck Surgery, The First Affiliated Hospital of Henan, Kaifeng 250061, Henan, China
  • Published:2022-06-15

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Abstract: Objective The aim of this study was to examine the relationship between single nucleotide polymorphisms of the RANTES gene(rs2107538 and rs2280788)and chronic sinusitis with bilateral nasal polyps(CRSwBNP)in the Han population of Jiangsu and Anhui regions. Methods One hundred and forty-one CRSwBNP patients(case group)and 108 healthy persons(control group)were enrolled, for a total of 249 participants. Clinical data were collected from all participants. Peripheral blood samples were collected and DNA was extracted. The RANTES gene locus(rs2107538 and rs2280788)was genotyped and the results were compared between case and control groups using logistic regression analysis. Results No significant differences in gender or age distribution were found between the case and control groups(P>0.05). CC, CT, and TT genotypes were detected at the rs2107538 locus and GG, CC, and CG genotypes were detected at the rs2280788 locus. The rs2107538 T allele was associated with a significantly increased risk of CRSwBNP(P=0.037, odds ratio［OR］=0.68, 95% confidence interval［CI］=0.47-0.98). The genotype at the rs2280788 locus was not associated with an increased risk of CRSwBNP. Linkage disequilibrium analysis showed that the RANTES rs2107538/rs2280788 C/G haplotype was protective against CRSwBNP(P=0.037, OR=0.68, 95%CI=0.47-0.98). Conclusion Thers2280788 polymorphism of the RANTES gene was not associated with CRSwBNP, but the rs2107538 polymorphism of the RANTES gene was associated with susceptibility to CRSwBNP.

Key words: RANTES gene, Single nucleotide polymorphism, Chronic sinusitis with bilateral nasal polyps, Cytokines

CLC Number: 

  • R765.25
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