Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2023, Vol. 37 ›› Issue (4): 126-133.doi: 10.6040/j.issn.1673-3770.0.2022.166

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Association between homocysteine concentration and the MTHFR C677T polymorphism and hypertension in patients with obstructive sleep apnea hypopnea syndrome

CHEN Shangli1,4, QIN Tao2, CHEN Xuan1, CHEN Ruojin1, TANG Zhi1,3   

  1. 1. Department of Otolaryngology & Head and Neck Surgery, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan 528300, Guangdong, China2. Department of Ultrasound, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan 528300, Guangdong, China3. Department of Ophthalmolgy and Otolaryngology, Xingtan Hospital, Shunde Hospital, Southern Medical University, Foshan 528300, Guangdong, China4. Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Sichuan Nursing Vocational College (The Third People's Hospital of Sichuan Province), Chengdu 610000, Sichuan, China
  • Published:2023-07-27

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Abstract: Objective The aim of this study was to investigate the relationships between homocysteine(Hcy)concentration and the C677T gene polymorphism in its key metabolic enzyme, methylenetetrahydrofolate reductase(MTHFR), and hypertension in patients with obstructive sleep apnea hypopnea syndrome(OSAHS). Methods Eighty-five patients with OSAHS, diagnosed by sleep monitoring, and 77 patients without OSAHS were included in this study. We determined MTHFR gene polymorphisms and serum Hcy, fasting blood glucose, and hemoglobin A1c concentrations in blood samples collected from all patients. Serum Hcy concentrations were compared between the TT, CT, and CC genotypes of the MTHFR C677T polymorphism. The Hcy concentration, MTHFR C677T genotype, and C/T allele frequency were compared between patients with OSAHS and hypertension, patients with OSAHS without hypertension, and the patients without OSAHS and hypertension. The factors associated with hypertension in OSAHS patients were evaluated using univariate and multiple Logistic regression analyses. Results The Hcy concentrations for the CC, CT, and TT genotypes were 10.11(9.15, 11.07)mol/L, 10.86(9.58, 11.10)mol/L and 15.81(11.43, 50.76)mol/L, respectively. Hcy concentrations were higher for the TT genotype than the CT(P=0.005)and CC(P<0.001)genotypes. The Hcy concentrations in patients with OSAHS and hypertension, patients with OSAHS without hypertension, and patients without OSAHS and hypertension were 11.21(10.08, 13.60)mol/L, 9.93(9.30, 11.42)mol/L and 10.32(9.33, 11.23)mol/L, respectively. Hcy concentrations were higher in patients with OSAHS and hypertension than in patients with OSAHS without hypertension(P=0.027)and patients without OSAHS and hypertension(P=0.039). After controlling for other confounding factors, hyperhomocysteinemia(HHcy)concentration was an independent risk factor for hypertension in patients with OSAHS(OR=4.160; 95%CI: 1.054, 16.418). There were no statistically significant differences in MTHFR C677T genotype or C/T allele frequency among the three groups. Conclusion The MTHFR C677T polymorphism affects serum Hcy concentrations, with the TT genotype showing higher concentrations than the CT and CC genotypes. HHcy concentration is an independent risk factor for hypertension in OSAHS patients, but neither the MTHFR C677T polymorphism nor the C/T allele frequency were associated with hypertension in OSAHS patients.

Key words: Obstructive sleep apnea hypopnea syndrome, Homocysteine, Methylenetetrahydrofolate reductase C677T, Hypertension

CLC Number: 

  • R76
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