Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2023, Vol. 37 ›› Issue (5): 142-148.doi: 10.6040/j.issn.1673-3770.0.2022.215

• Review • Previous Articles     Next Articles

Research progress in the relationship between autonomic nervous system dysfunction and nasal diseases

ZHANG Miao, YANG Yingchao, FU Zhihui, SU Kaiming   

  1. Department of Otorhinolaryngology & Head and Neck Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine/Otolaryngological Institute of Shanghai Jiao Tong University/Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai 200233, China
  • Published:2023-10-13

PDF (PC)

84

Abstract: The autonomic nervous system is composed of two parts: the sympathetic and the parasympathetic nervous systems. It plays an important role in maintaining the normal physiological activities of the body and the homeostasis of the internal environment. An imbalance in the autonomic nervous system can trigger a range of symptoms called autonomic nervous system dysfunction(ANSD). As nasal autonomic nerves are widely distributed,ANSD is not uncommon in nasal diseases. It has been verified that patients with rhinitis, sinusitis, deviated nasal septum and other diseases can develop ANSO. Some psychological symptoms such as anxiety and depression after nasal surgery and functional rhinoplasty may also be related to ANSD. This article reviews autonomic nerve dysfunction and nasal diseases, and aims to provide a better understanding of ANSD in nasal diseases.

Key words: Autonomic nerve system dysfunction, Nasal diseases, Symptom, Reflex, Assessment, Therapy

CLC Number: 

  • R765
[1] Wehrwein EA, Orer HS, Barman SM. Overview of the anatomy, physiology, and pharmacology of the autonomic nervous system[J]. Compr Physiol, 2016, 6(3): 1239-1278. doi:10.1002/cphy.c150037
[2] Goldberger JJ, Arora R, Buckley U, et al. Autonomic nervous system dysfunction: JACC focus seminar[J]. J Am Coll Cardiol, 2019, 73(10): 1189-1206. doi:10.1016/j.jacc.2018.12.064
[3] Sun HX, Nasi-Er BG, Wang XS, et al. Tragus nerve stimulation suppresses post-infarction ventricular arrhythmia by modulating autonomic activity and heterogeneities of cardiac receptor distribution[J]. Med Sci Monit, 2020, 26: e922277. doi:10.12659/MSM.922277
[4] Chen ZC, Li GL, Liu J. Autonomic dysfunction in Parkinson's disease: implications for pathophysiology, diagnosis, and treatment[J]. Neurobiol Dis, 2020, 134: 104700. doi:10.1016/j.nbd.2019.104700
[5] Makhmutova M, Weitz J, Tamayo A, et al. Pancreatic β-cells communicate with vagal sensory neurons[J]. Gastroenterology, 2021, 160(3): 875-888.e11. doi:10.1053/j.gastro.2020.10.034
[6] Abboud F, Kumar R. Obstructive sleep apnea and insight into mechanisms of sympathetic overactivity[J]. J Clin Invest, 2014, 124(4): 1454-1457. doi:10.1172/JCI70420
[7] Saladini F, di Marco A, Palatini P. Autonomic dysfunction: how to identify and when to treat? [J]. High Blood Press Cardiovasc Prev, 2016, 23(3): 237-243. doi:10.1007/s40292-016-0162-3
[8] Kirsch CFE. Headache caused by sinus disease[J]. Neuroimaging Clin N Am, 2019, 29(2): 227-241. doi:10.1016/j.nic.2019.01.003
[9] Lindemann J, Weindel C, Hoffmann TK, et al. re-evaluating the nasal cycle by long-term rhinoflowmetry: most individuals demonstrate a ‘mixed’ nasal cycle[J]. Rhinology, 2021, 59(6): 538-544. doi:10.4193/Rhin21.101
[10] Buchholz B, Kelly J, Bernatene EA, et al. Antagonistic and synergistic activation of cardiovascular vagal and sympathetic motor outflows in trigeminal reflexes[J]. Front Neurol, 2017, 8: 52. doi:10.3389/fneur.2017.00052
[11] Oliver J, Oliver GY. The oculo-cardiac reflex and endocrinology[J]. Edinb Med J, 1925, 32(2): 69-71
[12] Lemaitre F, Chowdhury T, Schaller B. The trigeminocardiac reflex-a comparison with the diving reflex in humans[J]. Arch Med Sci, 2015, 11(2): 419-426. doi:10.5114/aoms.2015.50974
[13] Özçelik D, Toplu G, Türkseven A, et al. The importance of the trigeminal cardiac reflex in rhinoplasty surgery[J]. Ann Plast Surg, 2015, 75(2): 213-218. doi:10.1097/SAP.0000000000000061
[14] Samitas K, Carter A, Kariyawasam HH, et al. Upper and lower airway remodelling mechanisms in asthma, allergic rhinitis and chronic rhinosinusitis: the one airway concept revisited[J]. Allergy, 2018, 73(5): 993-1002. doi:10.1111/all.13373
[15] Yamamoto Y, Yokoyama T, Nakamuta N. Morphology of GNAT3-immunoreactive chemosensory cells in the nasal cavity and pharynx of the rat[J]. J Anat, 2021, 239(2): 290-306. doi:10.1111/joa.13424
[16] Goadsby PJ, Lipton RB. A review of paroxysmal hemicranias, SUNCT syndrome and other short-lasting headaches with autonomic feature, including new cases[J]. Brain, 1997, 120( Pt 1): 193-209. doi:10.1093/brain/120.1.193
[17] Goadsby PJ. Trigeminal autonomic cephalalgias. pathophysiology and classification[J]. Rev Neurol(Paris), 2005, 161(6/7): 692-695. doi:10.1016/s0035-3787(05)85120-3
[18] Freeman R. Diabetic autonomic neuropathy[J]. Handb Clin Neurol, 2014, 126: 63-79. doi:10.1016/B978-0-444-53480-4.00006-0
[19] Benarroch EE. Physiology and pathophysiology of the autonomic nervous system[J]. Continuum(Minneap Minn), 2020, 26(1): 12-24. doi:10.1212/CON.0000000000000817
[20] Rafanelli M, Walsh K, Hamdan MH, et al. Autonomic dysfunction: diagnosis and management[J]. Handb Clin Neurol, 2019, 167: 123-137. doi:10.1016/b978-0-12-804766-8.00008-x
[21] Yao A, Wilson JA, Ball SL. Autonomic nervous system dysfunction and sinonasal symptoms[J]. Allergy Rhinol(Providence), 2018, 9: 2152656718764233. doi:10.1177/2152656718764233
[22] 程雷,陶绮蕾,王云丽. 血管运动性鼻炎的研究进展[J]. 中华耳鼻咽喉头颈外科杂志,2010,45(12):1056-1059. doi: 10.3760/cma.j.issn.1673-0860.2010.12.024
[23] Chen WC, Chang YT, Chen SF, et al. The symptom burden of autonomic dysfunction is positively associated with chronic rhinosinusitis status[J]. Rhinology, 2018, 56(3): 227-233. doi:10.4193/Rhin18.005
[24] Hayden FG, Diamond L, Wood PB, et al. Effectiveness and safety of intranasal ipratropium bromide in common colds. A randomized, double-blind, placebo-controlled trial[J]. Ann Intern Med, 1996, 125(2): 89-97. doi:10.7326/0003-4819-125-2-199607150-00002
[25] Seppänen TM, Alho OP, Seppänen T. Concomitant dynamic changes in autonomic nervous system function and nasal airflow resistance during allergen provocation[J]. Annu Int Conf IEEE Eng Med Biol Soc, 2015, 2015: 3339-3342. doi:10.1109/EMBC.2015.7319107
[26] Loehrl TA. Autonomic function and dysfunction of the nose and sinuses[J]. Otolaryngol Clin North Am, 2005, 38(6): 1155-1161. doi:10.1016/j.otc.2005.08.004
[27] Jaradeh SS, Smith TL, Torrico L, et al. Autonomic nervous system evaluation of patients with vasomotor rhinitis[J]. Laryngoscope, 2000, 110(11): 1828-1831. doi:10.1097/00005537-200011000-00012
[28] Loehrl TA, Smith TL, Darling RJ, et al. Autonomic dysfunction, vasomotor rhinitis, and extraesophageal manifestations of gastroesophageal reflux[J]. Otolaryngol Head Neck Surg, 2002, 126(4): 382-387. doi:10.1067/mhn.2002.123857
[29] 崔哲洙,韩玉,叶辉,等.血管运动性鼻炎的发病机制及治疗[J]. 山东大学耳鼻喉眼学报, 2007, 21(5): 446-448. doi: 10.3969/j.issn.1673-3770.2007.05.020 CUI Zhezhu, HAN Yu, YE Hui, et al. Pathogenesis and treatment of vasomotor rhinitis[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2007, 21(5): 446-448. doi: 10.3969/j.issn.1673-3770.2007.05.020
[30] Leader P, Geiger Z. Vasomotor Rhinitis[M]. Treasure Island(FL): StatPearls Publishing, 2022. PMID: 31613484
[31] Dykewicz MS, Wallace DV, Amrol DJ, et al. Rhinitis 2020: a practice parameter update[J]. J Allergy Clin Immunol, 2020, 146(4): 721-767. doi:10.1016/j.jaci.2020.07.007
[32] Emin O, Esra G, Ufuk E, et al. Autonomic dysfunction and clinical severity of disease in children with allergic rhinitis[J]. Int J Pediatr Otorhinolaryngol, 2012, 76(8): 1196-1200. doi:10.1016/j.ijporl.2012.05.005
[33] Ishman SL, Martin TJ, Hambrook DW, et al. Autonomic nervous system evaluation in allergic rhinitis[J]. Otolaryngol Head Neck Surg, 2007, 136(1): 51-56. doi:10.1016/j.otohns.2006.08.014
[34] Ozsutcu M, Ozkaya E, Demir A, et al. Pupillometric assessment of autonomic nervous system in children with allergic rhinitis[J]. Med Princ Pract, 2013, 22(5): 444-448. doi:10.1159/000350292
[35] Cerejeira R, Fernandes S, Pinto Moura C. Increased expression of α7nAChR in chronic rhinosinusitis: the intranasal cholinergic anti-inflammatory hypothesis[J]. Auris Nasus Larynx, 2016, 43(2): 176-181. doi:10.1016/j.anl.2015.08.011
[36] Tracey KJ. The inflammatory reflex[J]. Nature, 2002, 420(6917): 853-859. doi: 10.1038/nature01321
[37] Pereira MR, Leite PEC. The involvement of parasympathetic and sympathetic nerve in the inflammatory reflex[J]. J Cell Physiol, 2016, 231(9): 1862-1869. doi:10.1002/jcp.25307
[38] Acar B, Yavuz B, Karabulut H, et al. Parasympathetic overactivity in patients with nasal septum deformities[J]. Eur Arch Otorhinolaryngol, 2010, 267(1): 73-76. doi:10.1007/s00405-009-1055-z
[39] 高天喜, 李娜, 李桔林, 等. 气囊导尿管在鼻腔鼻窦肿瘤切除术后术腔填塞中的应用[J]. 山东大学耳鼻喉眼学报, 2021, 35(1): 11-15. doi:10.6040/j.issn.1673-3770.0.2020.075 GAO Tianxi, LI Na, LI Julin, et al. Application of air sac urinary catheter in nasal packing after endoscopic nasal surgery with a resection of sinonasal tumor[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(1): 11-15. doi:10.6040/j.issn.1673-3770.0.2020.075
[40] Mehle ME. What do we know about rhinogenic headache? The otolaryngologist's challenge[J]. Otolaryngol Clin North Am, 2014, 47(2): 255-264. doi:10.1016/j.otc.2013.10.006
[41] Dale LP, Cuffe SP, Kolacz J, et al. Increased autonomic reactivity and mental health difficulties in COVID-19 survivors: implications for medical providers[J]. Front Psychiatry, 2022, 13: 830926. doi:10.3389/fpsyt.2022.830926
[42] Jarrett ME, Burr RL, Cain KC, et al. Anxiety and depression are related to autonomic nervous system function in women with irritable bowel syndrome[J]. Dig Dis Sci, 2003, 48(2): 386-394. doi:10.1023/a: 1021904216312
[43] Blase K, Vermetten E, Lehrer P, et al. Neurophysiological approach by self-control of your stress-related autonomic nervous system with depression, stress and anxiety patients[J]. Int J Environ Res Public Health, 2021, 18(7): 3329. doi:10.3390/ijerph18073329
[44] Kanjanawasee D, Campbell RG, Rimmer J, et al. Empty nose syndrome pathophysiology: a systematic review[J]. Otolaryngol Head Neck Surg, 2022, 167(3): 434-451. doi:10.1177/01945998211052919
[45] Freeman R, Chapleau MW. Testing the autonomic nervous system[J]. Handb Clin Neurol, 2013, 115: 115-136. doi:10.1016/B978-0-444-52902-2.00007-2
[46] Kushki A, Drumm E, Pla Mobarak M, et al. Investigating the autonomic nervous system response to anxiety in children with autism spectrum disorders[J]. PLoS One, 2013, 8(4): e59730. doi:10.1371/journal.pone.0059730
[47] 蒋颖, 袁勇贵. 自主神经功能评定的研究进展[J]. 实用老年医学, 2018, 32(12): 1179-1182. doi:10.3969/j.issn.1003-9198.2018.12.022
[48] Suarez GA, Opfer-Gehrking TL, Offord KP, et al. The Autonomic Symptom Profile: a new instrument to assess autonomic symptoms[J]. Neurology, 1999, 52(3): 523-528. doi:10.1212/wnl.52.3.523
[49] Treister R, O'Neil K, Downs HM, et al. Validation of the composite autonomic symptom scale 31(COMPASS-31)in patients with and without small fiber polyneuropathy[J]. Eur J Neurol, 2015, 22(7): 1124-1130. doi:10.1111/ene.12717
[50] Fiuza-Luces C, Santos-Lozano A, Joyner M, et al. Exercise benefits in cardiovascular disease: beyond attenuation of traditional risk factors[J]. Nat Rev Cardiol, 2018, 15(12): 731-743. doi:10.1038/s41569-018-0065-1
[51] Chiancone FM. Vitamin B1 and autonomic drugs: a reprint[J]. Acta Vitaminol Enzymol, 1977, 31(6): 195-206
[52] Ramazani E, Akaberi M, Emami SA, et al. Biological and pharmacological effects of gamma-oryzanol: an updated review of the molecular mechanisms[J]. Curr Pharm Des, 2021, 27(19): 2299-2316. doi:10.2174/1381612826666201102101428
[53] Gumurdulu Y, Yapar Z, Canataroglu A, et al. Gastric emptying time and the effect of cisapride in cirrhotic patients with autonomic neuropathy[J]. J Clin Gastroenterol, 2003, 36(2): 175-178. doi:10.1097/00004836-200302000-00017
[54] Wang LM, Zhong ZY, Hu JY, et al. Sertraline plus deanxit to treat patients with depression and anxiety in chronic somatic diseases: a randomized controlled trial[J]. BMC Psychiatry, 2015, 15: 84. doi:10.1186/s12888-015-0449-2
[55] Sato A, Uchida S, Sato Y. Reflex modulation of visceral functions by acupuncture-like stimulation in anesthetized rats[J]. International Congress Series,Volume 1238,2002,Pages 111-123,ISSN 0531-5131,https://doi.org/10.1016/S0531-5131(02)00418-1
[56] Liu SB, Wang ZF, Su YS, et al. Somatotopic organization and intensity dependence in driving distinct NPY-expressing sympathetic pathways by electroacupuncture[J]. Neuron, 2020, 108(3): 436-450.e7. doi:10.1016/j.neuron.2020.07.015
[1] ZHOU Yijing, ZOU Jianyin, YI Hongliang, WU Hongmin. Expression of TGFBI in head and neck squamous cell carcinoma and its clinical significance [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(5): 85-95.
[2] TU Qiaoling, LI Yufeng, PENG Jun. Advances in anti-PD-L1/PD-1 therapy and non-coding RNA regulation in nasopharyngeal carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(5): 135-141.
[3] LUO Yiwen, XIAO Yongtao, GAO Minqian, YANG Jiayi, YANG Haidi. Progress in acoustic therapy for chronic subjective tinnitus [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(4): 13-23.
[4] ZHANG Hong, LI Xin. The role and mechanism of abnormal central nervous system activity in the occurrence of tinnitus [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(4): 24-29.
[5] DONG Hongsong, WANG Chunli, YU Yanping, CHEN Tao, NIE Guohui. A randomized controlled clinical trial of sound therapy combined with medication in the treatment of chronic subjective tinnitus [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(4): 30-37.
[6] XU Haiyan, CAO Wei, FAN Dachuan. Efficacy of compound sound therapy for patients with tinnitus and sudden deafness [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(4): 38-45.
[7] XIONG Binbin, LU Ziang, YANG Jing, XU Wenqiang, ZHOU Luru, SUN Pinyuan, YUAN Ding, ZHU Jiahao. Analysis of Cochlear function in young and middle-aged tinnitus patients with normal pure tone audiometry threshold [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(4): 62-67.
[8] SUN Yongqiang, SONG Zhongyi, WANG Chunfang, LI Xiao, FU Ying, PAN Xinliang. Prognosis and influencing factors in sudden deafness patients with acoustic stapedius reflex threshold [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(2): 7-14.
[9] HAN Feiyan, WANG Ying. Clinical analysis of 13 cases of neurilemmomas in the nasal cavity and paranasal sinuses [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(2): 21-25.
[10] REN Wei, LI Jia, ZHANG Xiong, ZHANG Shengjie. Electroacupuncture combined with manual moxibustion in the treatment of Meige syndrome: a case report and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(2): 63-66.
[11] AI Ziqin, LI Junzheng. Advances in immune vaccines for head and neck squamous cell carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(2): 143-150.
[12] WANG Xinyi, YANG Wenjie, YU Wenxing, XU Yanhong, HU Chunhong, MU Xiaosong, PU Xiaobing, REN Jianjun, ZHAO Yu. Effects and influencing factors of family-oriented customized sound therapy on patients with tinnitus and hearing loss [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(6): 70-76.
[13] REN Jia, LÜ Dan, ZHANG Yin, SUN Jiali, MA Lan, ZHENG Yitao, YANG Jimin, YU Lingyu, LI Bo. Application of combining fiberoptic endoscopic evaluation of swallowing technology and swallowing quality of life scale in patients with dysphagia after chemoradiotherapy for nasopharyngeal carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(6): 83-88.
[14] SHAO Na, ZHANG Qingqing, LIU Xiaohong, XIE Meng, GUO Ruixin, MA Sijing, LIU Haiqin, REN Xiaoyong, LUO Huanan. Effects of Helicobacter pylori infection on salivary pepsin concentration in patients with symptomatic laryngopharyngeal reflux [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(6): 89-95.
[15] LIU Lele, KONG XiangyunOverview,SHEN JiaquanGuidance. Progress of cyclodestructive surgeries for treating glaucoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(6): 123-128.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd