Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2023, Vol. 37 ›› Issue (5): 85-95.doi: 10.6040/j.issn.1673-3770.0.2022.459

• Original Article • Previous Articles     Next Articles

Expression of TGFBI in head and neck squamous cell carcinoma and its clinical significance

ZHOU Yijing, ZOU Jianyin, YI Hongliang, WU Hongmin   

  1. Department of Otolaryngology & Head and Neck Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China
  • Published:2023-10-13

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Abstract: Objective To explore the expression of transforming growth factor β induced gene(TGFBI)in head and neck squamous cell carcinoma(HNSCC)and its clinical significance. Methods Single-cell RNA-Seq sequencing data from the NCBI database were used to analyze TGFBI expression in immune cells and Bulk RNA-Seq was used to explore the infiltration of the tumor microenvironment in HNSCC. The gene expression and prognostic value of TGFBI in HNSCC were analyzed using TCGA database and validated using clinical specimens. TCGA database were used to assess the response of HNSCC patients to targeted therapy and immunotherapy after grouping according to TGFBI expression and to analyse the effect of gene mutations on TGFBI expression. Results High TGFBI was expressed in M2 macrophages. High TGFBI was associated with poor prognosis in patients with HNSCC. Patients with low TGFBI expression may respond to immunotherapy, while patients with high TGFBI expression may respond to targeted therapy. Mutations in TP53 were significantly associated with high TGFBI expression. Conclusion There is some evidence that TGFBI can be used as a biomarker for predicting survival and treatment response in patients with HNSCC.

Key words: Head and neck squamous cell carcinoma, Transforming growth factor β induced gene, Immune infiltration, Immunotherapy, Targeted therapy

CLC Number: 

  • R735.1
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