Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2023, Vol. 37 ›› Issue (3): 11-20.doi: 10.6040/j.issn.1673-3770.0.2022.262

• 论著 • Previous Articles    

Data mining on the pattern of medication in the management of vertigo by famous veteran Chinese medicine practitioners in modern times

ZHOU Yixing1, LI Dan1, CHEN Tengyu2, ZHOU Min3, HUANG Jiaqian1, WANG Sen1, LUO Shiwei1, HE Weiping4   

  1. 1. The First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China;
    2. Department of Otolaryngology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, Guangdong, China;
    3. Department of Allergy, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, Guangdong, China;
    4. Department of Otolaryngology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China
  • Published:2023-05-24

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Abstract: Objective To provide a reference for the clinical treatment of dizziness in Chinese herbal medicine by analyzing the prescriptions of modern famous veteran Chinese medicine practitioners for vertigo and compatibility rules. Methods The researchers in this study collected and sorted medical records on vertigo in seven books in accordance with the inclusion and exclusion criteria. After recording the frequency, four properties, five kinds of flavors, meridian entry and action classification of drugs, the researchers used the Origin 2022 software to draw radar charts of Chinese herbal medicine actions and medicinal properties. IBM SPSS Modeler 18.0 and Cytoscape 3.9.1 were used to display the core herbal medicine network, and the R 4.2.0 software was used to analyze and visualize the correlation and association rules. Additionally, SPSS Statistics 26.0 was used for cluster analysis of high-frequency drugs. Results A total of 178 medical records, 297 prescriptions and 289 Chinese herbal medicine data were collected for the management of vertigo. The total frequency was 3 684. Among them, the Chinese herbs were mainly tonics, liver-soothing drugs, heat-clearing drugs, exterior-relieving drugs and blood-activating and stasis-resolving drugs. The four properties of the herbs were mainly cold and warm, the distribution of the five kinds of flavor included mostly sweet, bitter and acrid the main meridians were the liver, spleen and lung. Thirty-seven herbs were used ≥ 30 times. The top forty drug pairs with high correlation coefficients were mostly tonics, blood-activating and stasis-resolving drugs and liver-soothing drugs. The most used two-drug pair was “Fossilia Mastodi Ossis and Concha Ostreae” and there were six groups of three-drug combinations. There were four new prescriptions for the management of vertigo. Conclusion The treatment of vertigo by the famous veteran Chinese medicine practitioners was mainly with liver-soothing drugs, qi and blood-nourishing drugs, phlegm-resolving and dampness-eliminating drugs, blood-activating and orifice-dredging drugs, and more, which reflect the basic principles of clinical management of dizziness. The study provides a theoretical basis for the research and development of clinical Chinese patent medicines and new drugs by exploring and analyzing the pattern of medication in the management of vertigo by famous veteran Chinese medicine practitioners, and helps to inherit and carry forward the valuable experience of vertigo treatment from famous veteran Chinese medicine practitioners.

Key words: Vertigo, Famous veteran Chinese medicine practitioner, Prescription rule, Core drug, Data mining

CLC Number: 

  • R276.1
[1] 中国医药教育协会眩晕专业委员会,中国医师协会急诊医师分会. 眩晕急诊诊断与治疗指南(2021年)[J]. 中华急诊医学杂志,2021,30(4):402-406. doi:10.3760/cma.j.issn.1671-0282.2021.04.005
[2] Tolisano AM, Song SA, Ruhl DS, et al. Dizziness, malpractice, and the otolaryngologist[J]. Am J Otolaryngol, 2017, 38(4): 401-404. doi:10.1016/j.amjoto.2017.03.009
[3] Muir SW, Berg K, Chesworth B, et al. Quantifying the magnitude of risk for balance impairment on Falls in community-dwelling older adults: a systematic review and meta-analysis[J]. J Clin Epidemiol, 2010, 63(4): 389-406. doi:10.1016/j.jclinepi.2009.06.010
[4] Lindell E, Kollén L, Johansson M, et al. Dizziness and its association with walking speed and Falls efficacy among older men and women in an urban population[J]. Aging Clin Exp Res, 2020, 32(6): 1049-1056. doi:10.1007/s40520-019-01303-6
[5] Lai YF, Wang RN, Li W, et al. Clinical and economic analysis of Gastrodin injection for dizziness or Vertigo: a retrospective cohort study based on electronic health records in China[J]. Chin Med, 2022, 17(1): 6. doi:10.1186/s13020-021-00561-9
[6] 刘立军, 苏文全, 吴圣贤. 试论眩晕症状与病证之间的区别与联系[J]. 光明中医, 2022, 37(4): 579-581. doi: 10.3969/j.issn.1003-8914.2022.04.013
[7] 李剑颖, 赵丹丹, 杨建宇. 国医大师验案良方:心脑卷[M]. 北京: 学苑出版社, 2010: 223-277.
[8] 梅祥胜, 李丽, 杨明杰. 国医大师验案良方:五官卷[M]. 北京: 学苑出版社, 2010: 280-307.
[9] 贺兴东, 翁维良, 姚乃礼. 当代名老中医典型医案集·内科分册(上册)[M]. 北京: 人民卫生出版社, 2009: 229-255.
[10] 贺兴东, 翁维良, 姚乃礼. 当代名老中医典型医案集·内科分册(中册)[M]. 北京: 人民卫生出版社, 2009.
[11] 贺兴东, 翁维良, 姚乃礼. 当代名老中医典型医案集·内科分册(下册)[M]. 北京: 人民卫生出版社, 2009: 1157-1189.
[12] 干祖望,张文康. 中国百年百名中医临床家丛书-干祖望[M]. 北京: 中国中医药出版社, 2001: 78-84.
[13] 单书健, 陈子华. 古今名医临证金鉴(头痛眩晕卷)[M]. 北京: 中国中医药出版社, 2011: 220-427.
[14] 钟赣生. 中药学[M]. 4版. 北京: 中国中医药出版社, 2016.
[15] 国家药典委员会. 中华人民共和国药典-一部: 2020年版[M]. 北京: 中国医药科技出版社, 2020.
[16] 南京中医药大学. 中药大辞典(全2册)[M]. 上海: 上海科学技术出版社, 2006.
[17] 国家中医药管理局《中华本草》编委会编. 中华本草[M]. 上海: 上海科学技术出版社, 1999.
[18] 王国强. 全国中草药汇编-卷四[M]. 3版. 北京: 人民卫生出版社, 2014.
[19] 谢慧. 眩晕的中医认识[J]. 山东大学耳鼻喉眼学报, 2019, 33(5): 11-17. doi: 10.6040/j.issn.1673-3770.1.2019.044 XIE Hui. Understanding Vertigo from a Chinese medicine perspective[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(5): 11-17. doi: 10.6040/j.issn.1673-3770.1.2019.044
[20] 周仲瑛. 中医内科学[M]. 北京: 中国中医药出版社, 2008: 297-302.
[21] 王士贞. 中医耳鼻咽喉科临床研究[M]. 北京: 人民卫生出版社, 2009: 135.
[22] 邓桃妹, 彭代银, 俞年军, 等. 茯苓化学成分和药理作用研究进展及质量标志物的预测分析[J]. 中草药, 2020, 51(10): 2703-2717. doi:10.7501/j.issn.0253-2670.2020.10.013 DENG Taomei, PENG Daiyin, YU Nianjun, et al. Research progress on chemical composition and pharmacological effects of Poria cocos and predictive analysis on quality markers[J]. Acupuncture Research, 2020, 51(10): 2703-2717. doi:10.7501/j.issn.0253-2670.2020.10.013
[23] 柳威, 邓林华, 祁东利, 等. 天麻及其有效成分的药理作用概述[J]. 中药药理与临床, 2021, 37(4): 240-244. doi:10.13412/j.cnki.zyyl.20210120.003 LIU Wei, DENG Linhua, QI Dongli, et al. Overview of the pharmacological effects of Gastrodia and its active ingredients[J]. Pharmacology and Clinics of Chinese Materia Medica, 2021, 37(4): 240-244, 12. doi:10.13412/j.cnki.zyyl.20210120.003
[24] Shin H, Chung M, Rose DZ. Licorice root associated with intracranial hemorrhagic stroke and cerebral microbleeds[J]. Neurohospitalist, 2019, 9(3): 169-171. doi:10.1177/1941874418805332
[25] 张维霞, 苏萍, 赵爱军. 白术的炮制方法及其药理作用研究进展[J]. 中医药导报, 2022, 28(5): 110-115. doi:10.13862/j.cn43-1446/r.2022.05.023 ZHANG Weixia, SU Ping, ZHAO Aijun. Research progress on the processing methods and pharmacological effects of baizhu(Atractylodes macrocephala)[J]. Guiding Journal of Traditional Chinese Medicine and Pharmacy, 2022, 28(5): 110-115. doi:10.13862/j.cn43-1446/r.2022.05.023
[26] 杨丁友, 吴兴利, 于洋, 等. 不同炮制方法的半夏对老年单纯收缩期高血压患者血压的影响[J]. 中医杂志, 2011, 52(7): 575-577. doi:10.13288/j.11-2166/r.2011.07.036 YANG Dingyou, WU Xingli, YU Yang, et al. Influence of differently-processed Banxia on the blood pressure of elderly isolated systolic hypertension patients[J]. Journal of Traditional Chinese Medicine, 2011, 52(7): 575-577. doi:10.13288/j.11-2166/r.2011.07.036
[27] 韩蕾, 周晓辉, 王维伟, 等. 白芍总苷对腹主动脉结扎所致大鼠心肌重构的影响[J]. 中华中医药学刊, 2011, 29(2): 330-334. doi:10.13193/j.archtcm.2011.02.108.hanl.054 HAN Lei, ZHOU Xiaohui, WANG Weiwei, et al. Experimental researches of glucosides of Radix paeoniae alba on reversing myocardial remodeling induced by abdominal aortic ligation(partial occlusion)[J]. Chinese Archives of Traditional Chinese Medicine, 2011, 29(2): 330-334. doi:10.13193/j.archtcm.2011.02.108.hanl.054
[28] 陈燕伟, 马善波, 权伟, 等. 柴胡皂苷D对慢性应激诱导小鼠焦虑症的影响[J]. 陕西中医, 2021, 42(6): 705-708. doi:10.3969/j.issn.1000-7369.2021.06.006 CHEN Yanwei, MA Shanbo, QUAN Wei, et al. Effect of saikosaponin D on anxiety disorder induced by chronic stress in mice[J]. Shaanxi Journal of Traditional Chinese Medicine, 2021, 42(6): 705-708. doi:10.3969/j.issn.1000-7369.2021.06.006
[29] Su J, Pan YW, Wang SQ, et al. Saikosaponin-d attenuated lipopolysaccharide-induced depressive-like behaviors via inhibiting microglia activation and neuroinflammation[J]. Int Immunopharmacol, 2020, 80: 106181. doi:10.1016/j.intimp.2019.106181
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